Open Access
24 July 2019 Does group velocity always reflect elastic modulus in shear wave elastography?
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Abstract

Dynamic elastography is an attractive method to evaluate tissue biomechanical properties. Recently, it was extended from US- and MR-based modalities to optical ones, such as optical coherence tomography for three-dimensional (3-D) imaging of propagating mechanical waves in subsurface regions of soft tissues, such as the eye. The measured group velocity is often used to convert wave speed maps into 3-D images of the elastic modulus distribution based on the assumption of bulk shear waves. However, the specific geometry of OCE measurements in bounded materials such as the cornea and skin calls into question elasticity reconstruction assuming a simple relationship between group velocity and shear modulus. We show that in layered media the bulk shear wave assumption results in highly underestimated shear modulus reconstructions and significant structural artifacts in modulus images. We urge the OCE community to be careful in using the group velocity to evaluate tissue elasticity and to focus on developing robust reconstruction methods to accurately reconstruct images of the shear elastic modulus in bounded media.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Ivan Pelivanov, Liang Gao, John Pitre, Mitchell A. Kirby, Shaozhen Song, David Li, Tueng T. Shen, Ruikang K. Wang, and Matthew O'Donnell "Does group velocity always reflect elastic modulus in shear wave elastography?," Journal of Biomedical Optics 24(7), 076003 (24 July 2019). https://doi.org/10.1117/1.JBO.24.7.076003
Received: 3 April 2019; Accepted: 8 July 2019; Published: 24 July 2019
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CITATIONS
Cited by 36 scholarly publications.
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KEYWORDS
Wave propagation

Tissues

Dispersion

Elastography

Optical coherence tomography

Phase velocity

Waveguides


CHORUS Article. This article was made freely available starting 23 July 2020

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