Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography

Mehrana Mohtasebi; Daniel Irwin; Dara Singh; Siavash Mazdeyasna; Xuhui Liu; Samaneh Rabienia Haratbar; Faraneh Fathi; Chong Huang; Kathryn E. Saatman; Lei Chen; Guoqiang Yu

doi:10.1117/1.JBO.28.12.121204

4 May 2023 Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography

Mehrana Mohtasebi, Daniel Irwin, Dara Singh, Siavash Mazdeyasna, Xuhui Liu, Samaneh Rabienia Haratbar, Faraneh Fathi, Chong Huang, Kathryn E. Saatman, Lei Chen, Guoqiang Yu

Author Affiliations +

Journal of Biomedical Optics, Vol. 28, Issue 12, 121204 (May 2023). https://doi.org/10.1117/1.JBO.28.12.121204

Abstract

Significance

Low-frequency oscillations (LFOs) (<0.1 Hz) with respect to cerebral blood flow (CBF) have shown promise as an indicator of altered neurologic activity in the abnormal brain. Portable optical instruments have evolved to offer a noninvasive alternative for continuous CBF monitoring at the bedside compared with many large neuroimaging modalities. However, their utilization for acquiring LFOs of CBF has only been studied to a limited extent.

Aim

We aim to optimize an innovative speckle contrast diffuse correlation tomography (scDCT) system for the detection of LFOs within CBF variations.

Approach

The scDCT was optimized to achieve a higher sampling rate and a faster image reconstruction using a moving window 3D reconstruction algorithm with parallel computation. Power spectral density (PSD) analysis was performed to investigate altered LFOs during transient global cerebral ischemia in neonatal piglets.

Results

Transient global cerebral ischemia resulted in reductions in both CBF and PSD compared with their baseline values.

Conclusions

Spontaneous LFOs, combined with CBF, provide a more comprehensive assay with the potential to clarify pathological mechanisms involved in brain injury. These results support scDCT’s inclusion and application in the growing area of LFO analysis and demonstrate its inherent advantage for neurological studies in preclinical and clinical settings, such as neonatal intensive care units.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Mehrana Mohtasebi, Daniel Irwin, Dara Singh, Siavash Mazdeyasna, Xuhui Liu, Samaneh Rabienia Haratbar, Faraneh Fathi, Chong Huang, Kathryn E. Saatman, Lei Chen, and Guoqiang Yu "Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography," Journal of Biomedical Optics 28(12), 121204 (4 May 2023). https://doi.org/10.1117/1.JBO.28.12.121204

Received: 5 December 2022; Accepted: 18 April 2023; Published: 4 May 2023

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