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8 August 2023 Porcine vocal fold elasticity evaluation using Brillouin spectroscopy
Vsevolod Cheburkanov, Ethan B. Keene, Jason Pipal, Michael Johns, Brian E. Applegate, Vladislav V. Yakovlev
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Journal of Biomedical Optics, Vol. 28, Issue 8, 087002 (August 2023). https://doi.org/10.1117/1.JBO.28.8.087002
Abstract

Significance

The vocal folds are critically important structures within the larynx which serve the essential functions of supporting the airway, preventing aspiration, and phonation. The vocal fold mucosa has a unique multilayered architecture whose layers have discrete viscoelastic properties facilitating sound production. Perturbations in these properties lead to voice loss. Currently, vocal fold pliability is inferred clinically using laryngeal videostroboscopy and no tools are available for in vivo objective assessment.

Aim

The main objective of the present study is to evaluate viability of Brillouin microspectroscopy for differentiating vocal folds’ mechanical properties against surrounding tissues.

Approach

We used Brillouin microspectroscopy as an emerging optical imaging modality capable of providing information about local viscoelastic properties of tissues in noninvasive and remote manner.

Results

Brillouin measurements of the porcine larynx vocal folds were performed. Elasticity-driven Brillouin spectral shifts were recorded and analyzed. Elastic properties, as assessed by Brillouin spectroscopy, strongly correlate with those acquired using classical elasticity measurements.

Conclusions

These results demonstrate the feasibility of Brillouin spectroscopy for vocal fold imaging. With more extensive research, this technique may provide noninvasive objective assessment of vocal fold mucosal pliability toward objective diagnoses and more targeted treatments.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Vsevolod Cheburkanov, Ethan B. Keene, Jason Pipal, Michael Johns, Brian E. Applegate, and Vladislav V. Yakovlev "Porcine vocal fold elasticity evaluation using Brillouin spectroscopy," Journal of Biomedical Optics 28(8), 087002 (8 August 2023). https://doi.org/10.1117/1.JBO.28.8.087002
Received: 8 January 2023; Accepted: 21 July 2023; Published: 8 August 2023
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KEYWORDS
Elasticity
Spectroscopy
Tissues
Imaging spectroscopy
Biological samples
Materials properties
Iodine
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