Multi-frequency spatial frequency domain imaging: a depth-resolved optical scattering model to isolate scattering contrast in thin layers of skin

Luigi Belcastro; Hanna Jonasson; Rolf B. Saager

doi:10.1117/1.JBO.29.4.046003

22 April 2024 Multi-frequency spatial frequency domain imaging: a depth-resolved optical scattering model to isolate scattering contrast in thin layers of skin

Luigi Belcastro, Hanna Jonasson, Rolf B. Saager

Author Affiliations +

Journal of Biomedical Optics, Vol. 29, Issue 4, 046003 (April 2024). https://doi.org/10.1117/1.JBO.29.4.046003

Abstract

Significance

Current methods for wound healing assessment rely on visual inspection, which gives qualitative information. Optical methods allow for quantitative non-invasive measurements of optical properties relevant to wound healing.

Aim

Spatial frequency domain imaging (SFDI) measures the absorption and reduced scattering coefficients of tissue. Typically, SFDI assumes homogeneous tissue; however, layered structures are present in skin. We evaluate a multi-frequency approach to process SFDI data that estimates depth-specific scattering over differing penetration depths.

Approach

Multi-layer phantoms were manufactured to mimic wound healing scattering contrast in depth. An SFDI device imaged these phantoms and data were processed according to our multi-frequency approach. The depth sensitive data were then compared with a two-layer scattering model based on light fluence.

Results

The measured scattering from the phantoms changed with spatial frequency as our two-layer model predicted. The performance of two δ-P1 models solutions for SFDI was consistently better than the standard diffusion approximation.

Conclusions

We presented an approach to process SFDI data that returns depth-resolved scattering contrast. This method allows for the implementation of layered optical models that more accurately represent physiologic parameters in thin tissue structures as in wound healing.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Luigi Belcastro, Hanna Jonasson, and Rolf B. Saager "Multi-frequency spatial frequency domain imaging: a depth-resolved optical scattering model to isolate scattering contrast in thin layers of skin," Journal of Biomedical Optics 29(4), 046003 (22 April 2024). https://doi.org/10.1117/1.JBO.29.4.046003

Received: 29 August 2023; Accepted: 28 March 2024; Published: 22 April 2024

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KEYWORDS

Scattering

Analytic models

Data modeling

Light scattering

Spatial frequencies

Tissues

Performance modeling

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