Prevention of nonspecific adsorption onto a poly(dimethylsiloxane) microchannel in a microsensor chip by using a self-assembled monolayer

Toshikazu Kawaguchi; Hiroyuki Iwasaka; Kiyoshi Matsumoto; Kiyoshi Toko; Norio Miura

doi:10.1117/1.3366559

1 January 2010 Prevention of nonspecific adsorption onto a poly(dimethylsiloxane) microchannel in a microsensor chip by using a self-assembled monolayer

Toshikazu Kawaguchi, Hiroyuki Iwasaka, Kiyoshi Matsumoto, Kiyoshi Toko, Norio Miura

Author Affiliations +

Journal of Micro/Nanolithography, MEMS, and MOEMS, Vol. 9, Issue 1, 013012 (January 2010). https://doi.org/10.1117/1.3366559

Abstract

Poly (dimethylsiloxane) (PDMS) is meant to be utilized for a miniaturized sensor system. However, protein and biospecies often adsorb onto a PDMS surface nonspecifically. This matter is a serious challenge in the study of miniaturized sensor systems. We provide the solution, which is a prevention technique of nonspecific adsorption onto a PDMS microchip by using a functionalized silane compound self-assembled monolayer. Two demonstrations for bacteria and explosives were examined by atomic force microscopy and x-ray photoelectron spectroscopy. It was found that 1H, 1H, 2H, 2H-Perfluorooctyltriethoxysilane self-assembled monolayer on PDMS effectively blocked the nonspecific adsorption of Escherichia coli (O157:H7) and explosives such as 2, 4, 6-trinitrotoluene and 1, 3, 5-trinitroperhydro-1,3,5-triazine (RDX, Research Department Explosive).

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Toshikazu Kawaguchi, Hiroyuki Iwasaka, Kiyoshi Matsumoto, Kiyoshi Toko, and Norio Miura "Prevention of nonspecific adsorption onto a poly(dimethylsiloxane) microchannel in a microsensor chip by using a self-assembled monolayer," Journal of Micro/Nanolithography, MEMS, and MOEMS 9(1), 013012 (1 January 2010). https://doi.org/10.1117/1.3366559

Published: 1 January 2010

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