Comparison of cerebral metabolic rate of oxygen, blood flow, and bispectral index under general anesthesia

Susanna Tagliabue; Claus Lindner; Ivette Chochron da Prat; Angela Sanchez-Guerrero; Isabel Serra; Michał Kacprzak; Federica Maruccia; Olga Martinez Silva; Udo M. Weigel; Miriam de Nadal; Maria A. Poca; Turgut Durduran

doi:10.1117/1.NPh.10.1.015006

6 March 2023 Comparison of cerebral metabolic rate of oxygen, blood flow, and bispectral index under general anesthesia

Susanna Tagliabue, Claus Lindner, Ivette Chochron da Prat, Angela Sanchez-Guerrero, Isabel Serra, Michał Kacprzak, Federica Maruccia, Olga Martinez Silva, Udo M. Weigel, Miriam de Nadal, Maria A. Poca, Turgut Durduran

Author Affiliations +

Neurophotonics, Vol. 10, Issue 1, 015006 (March 2023). https://doi.org/10.1117/1.NPh.10.1.015006

Abstract

Significance

The optical measurement of cerebral oxygen metabolism was evaluated.

Aim

Compare optically derived cerebral signals to the electroencephalographic bispectral index (BIS) sensors to monitor propofol-induced anesthesia during surgery.

Approach

Relative cerebral metabolic rate of oxygen (rCMRO₂) and blood flow (rCBF) were measured by time-resolved and diffuse correlation spectroscopies. Changes were tested against the relative BIS (rBIS) ones. The synchronism in the changes was also assessed by the R-Pearson correlation.

Results

In 23 measurements, optically derived signals showed significant changes in agreement with rBIS: during propofol induction, rBIS decreased by 67% [interquartile ranges (IQR) 62% to 71%], rCMRO₂ by 33% (IQR 18% to 46%), and rCBF by 28% (IQR 10% to 37%). During recovery, a significant increase was observed for rBIS (48%, IQR 38% to 55%), rCMRO₂ (29%, IQR 17% to 39%), and rCBF (30%, IQR 10% to 44%). The significance and direction of the changes subject-by-subject were tested: the coupling between the rBIS, rCMRO₂, and rCBF was witnessed in the majority of the cases (14/18 and 12/18 for rCBF and 19/21 and 13/18 for rCMRO₂ in the initial and final part, respectively). These changes were also correlated in time (R > 0.69 to R = 1, p-values < 0.05).

Conclusions

Optics can reliably monitor rCMRO₂ in such conditions.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Susanna Tagliabue, Claus Lindner, Ivette Chochron da Prat, Angela Sanchez-Guerrero, Isabel Serra, Michał Kacprzak, Federica Maruccia, Olga Martinez Silva, Udo M. Weigel, Miriam de Nadal, Maria A. Poca, and Turgut Durduran "Comparison of cerebral metabolic rate of oxygen, blood flow, and bispectral index under general anesthesia," Neurophotonics 10(1), 015006 (6 March 2023). https://doi.org/10.1117/1.NPh.10.1.015006

Received: 27 July 2022; Accepted: 7 February 2023; Published: 6 March 2023

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