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20 January 2024 Pulsatile microvascular cerebral blood flow waveforms change with intracranial compliance and age
Nikita Kedia, Michael M. McDowell, Jason Yang, Jingyi Wu, Robert M. Friedlander, Jana M. Kainerstorfer
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Neurophotonics, Vol. 11, Issue 1, 015003 (January 2024). https://doi.org/10.1117/1.NPh.11.1.015003
Abstract

Significance

Diffuse correlation spectroscopy (DCS) is an optical method to measure relative changes in cerebral blood flow (rCBF) in the microvasculature. Each heartbeat generates a pulsatile signal with distinct morphological features that we hypothesized to be related to intracranial compliance (ICC).

Aim

We aim to study how three features of the pulsatile rCBF waveforms: the augmentation index (AIx), the pulsatility index, and the area under the curve, change with respect to ICC. We describe ICC as a combination of vascular compliance and extravascular compliance.

Approach

Since patients with Chiari malformations (CM) (n=30) have been shown to have altered extravascular compliance, we compare the morphology of rCBF waveforms in CM patients with age-matched healthy control (n=30).

Results

AIx measured in the supine position was significantly less in patients with CM compared to healthy controls (p<0.05). Since physiologic aging also leads to changes in vessel stiffness and intravascular compliance, we evaluate how the rCBF waveform changes with respect to age and find that the AIx feature was strongly correlated with age (Rhealthy subjects=−0.63, Rpreoperative CM patient=−0.70, and Rpostoperative CM patients=−0.62, p<0.01).

Conclusions

These results suggest that the AIx measured in the cerebral microvasculature using DCS may be correlated to changes in ICC.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Nikita Kedia, Michael M. McDowell, Jason Yang, Jingyi Wu, Robert M. Friedlander, and Jana M. Kainerstorfer "Pulsatile microvascular cerebral blood flow waveforms change with intracranial compliance and age," Neurophotonics 11(1), 015003 (20 January 2024). https://doi.org/10.1117/1.NPh.11.1.015003
Received: 1 August 2023; Accepted: 26 December 2023; Published: 20 January 2024
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KEYWORDS
Curium
Compliance
Cerebral blood flow
Blood circulation
Neurophotonics
Surgery
Brain
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