Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom and in vivo tests

Rebecca Re; Edoardo Martinenghi; Alberto Dalla Mora; Davide Contini; Antonio Pifferi; Alessandro Torricelli

doi:10.1117/1.NPh.3.4.045004

12 October 2016 Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom and in vivo tests

Rebecca Re, Edoardo Martinenghi, Alberto Dalla Mora, Davide Contini, Antonio Pifferi, Alessandro Torricelli

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Neurophotonics, Vol. 3, Issue 4, 045004 (October 2016). https://doi.org/10.1117/1.NPh.3.4.045004

Abstract

We report the development of a compact probe for time-domain (TD) functional near-infrared spectroscopy (fNIRS) based on a fast silicon photomultiplier (SiPM) that can be put directly in contact with the sample without the need of optical fibers for light collection. We directly integrated an avalanche signal amplification stage close to the SiPM, thus reducing the size of the detection channel and optimizing the signal immunity to electromagnetic interferences. The whole detection electronics was placed in a plastic screw holder compatible with the electroencephalography standard cap for measurement on brain or with custom probe holders. The SiPM is inserted into a transparent and insulating resin to avoid the direct contact of the scalp with the 100-V bias voltage. The probe was integrated in an instrument for TD fNIRS spectroscopy. The system was characterized on tissue phantoms in terms of temporal resolution, responsivity, linearity, and capability to detect deep absorption changes. Preliminary in vivo tests on adult volunteers were performed to monitor hemodynamic changes in the arm during a cuff occlusion and in the brain cortex during a motor task.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Rebecca Re, Edoardo Martinenghi, Alberto Dalla Mora, Davide Contini, Antonio Pifferi, and Alessandro Torricelli "Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom and in vivo tests," Neurophotonics 3(4), 045004 (12 October 2016). https://doi.org/10.1117/1.NPh.3.4.045004

Published: 12 October 2016

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