CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > Neurophoton. > Volume 4 > Issue 3 > Article
Open Access
7 April 2017 From brain to blood vessels and back: a noninvasive optical imaging approach
Gabriele Gratton, Antonio M. Chiarelli, Monica Fabiani
Author Affiliations +
Neurophotonics, Vol. 4, Issue 3, 031208 (April 2017). https://doi.org/10.1117/1.NPh.4.3.031208
Abstract
The seminal work of Grinvald et al. has paved the way for the use of intrinsic optical signals measured with reflection methods for the analysis of brain function. Although this work has focused on the absorption signal associated with deoxygenation, due to its detailed mapping ability and good signal-to-noise ratio, Grinvald’s group has also described other intrinsic signals related to increased blood flow, scattering effects directly related to neural activation, and pulsation effects related to arterial function. These intrinsic optical signals can also be measured using noninvasive diffuse optical topographic and tomographic imaging (DOT) methods that can be applied to humans. Here we compare the reflection and DOT methods and the evidence for each type of intrinsic signal in these two domains, with particular attention to work that has been conducted in our laboratory. This work reveals the refined two-way relationship that exists between vascular and neural phenomena in the brain: arterial health is related to normal brain structure and function, both across individuals and across brain regions within an individual, and neural function influences blood flow to specific cortical regions. DOT methods can provide quantitative tools for investigating these relationships in normal human subjects.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Gabriele Gratton, Antonio M. Chiarelli, and Monica Fabiani "From brain to blood vessels and back: a noninvasive optical imaging approach," Neurophotonics 4(3), 031208 (7 April 2017). https://doi.org/10.1117/1.NPh.4.3.031208
Received: 15 January 2017; Accepted: 10 March 2017; Published: 7 April 2017
JOURNAL ARTICLE
 10 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 18 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Brain
Diffuse optical imaging
Visualization
Arteries
Blood vessels
Hemodynamics
Neuroimaging
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top