Post-treatment colorectal cancer tissue often contains fibrosis and edema in tumor bed, photoacoustic elastography is a good tool for evaluating the elasticity change in post treatment colorectal cancer, especially in ultrasonically homogeneous and hypoechogenic regions. We implemented photoacoustic elastography for post-treatment colorectal cancer, developed elasticity phantoms to simulate colon scanning to evaluate elasticity measurement accuracy, applied it in ex vivo tissue scan to evaluate the elasticity change with ultrasound and photoacoustic signal. Results demonstrated good correspondence between ultrasound and photoacoustic elasticity phantom measurements, and showed potential of elasticity measurement with a normal ex vivo colon scan.
Colorectal cancer ranks as the second most prevalent global malignancy and stands as the fourth leading cause of cancer-related deaths in the United States. The ability to accurately monitor rectal cancer treatment responses poses a significant challenge given the limitations of existing imaging modalities in confirming pathological complete response after chemoradiation. Non-invasive confirmation of complete response can offer improved quality of life, reduced medical costs, and decreased strain on the healthcare system for patients. Previous findings from our research group highlighted the potential of co-registered acoustic-resolution Photoacoustic Microscopy (ARPAM) and ultrasound (ARPAM/US) in monitoring treatment response, revealing the recovery of regular microvascular patterns in the tumor bed through photoacoustic microscopy in treatment responders. In this presentation, we introduce a second-generation compact and robust ARPAM/US system designed for monitoring rectal cancer treatment responses in an endoscopy unit suitable for repeated imaging. We will present a comparative analysis between normal tissue and tumor bed with and without residual tumor after chemoradiation.
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