Current publications show promising results in the in-vivo detection of amyloid deposits in the retina of Alzheimer’s disease (AD) patients as well in post-mortem flat mounted retinal tissue. The results are promising for the detection of early alterations associated with AD. The aim of our study was to confirm recently published findings using almost identical methodology, blue (ex: λ = 486 nm) fluorescence retinal imaging, curcumin as labelling fluorophore, and a similar data analyzing process.
Polarization sensitive optical coherence tomography (PS-OCT) has been used to visualize the orientation of the nerves in the retinal nerve fiber layer (RNFL) and to visualize depolarization in retinas of healthy volunteers and age-related macular degeneration (AMD) patients. Optic axis orientation images clearly visualize the nerve fibers leaving the optic nerve head (ONH) in all radial directions in healthy volunteers. Depolarization images show depolarization of the RPE and for some cases, highlight another depolarizing layer at the boundary of the choroid and sclera.
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