Dr. Alexander D. Klose Profile

Dr. Alexander D. Klose

SPIE Involvement:

Author

Publications (26)

Proceedings Article | 25 February 2020 Paper

In vivo bioluminescence tomography-guided radiation research platform for pancreatic cancer: an initial study using subcutaneous and orthotopic pancreatic tumor models

Zijian Deng, Xiangkun Xu, Hamid Dehghani, Juvenal Reyes, Lei Zheng, Alexander Klose, John Wong, Phuoc Tran, Ken Kang-Hsin Wang

Proceedings Volume 11224, 1122409 (2020) https://doi.org/10.1117/12.2546503

KEYWORDS: Tumors, 3D modeling, Pancreatic cancer, In vivo imaging, Animal model studies, Pancreas, Bioluminescence, Tissues

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Proceedings Article | 15 June 2011 Paper

Hyperspectral fluorescence tomography of quantum dots using the simplified spherical harmonics equations

Alexander Klose, Yared Tekabe, Lynne Johnson

Proceedings Volume 8088, 80880V (2011) https://doi.org/10.1117/12.889704

KEYWORDS: Luminescence, Tissues, Tissue optics, Natural surfaces, Imaging systems, Absorption, Quantum dots, Spherical lenses, Light sources, Fluorescence tomography

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Proceedings Article | 17 February 2011 Paper

Hyperspectral fluorescence tomography of quantum dots

Alexander Klose

Proceedings Volume 7896, 78962P (2011) https://doi.org/10.1117/12.875021

KEYWORDS: Luminescence, Tissues, Quantum dots, Absorption, Tissue optics, Imaging systems, Light sources, Fluorescence tomography, 3D image reconstruction, Light wave propagation

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SPIE Journal Paper | 1 November 2010 Open Access

Computer-aided interpretation approach for optical tomographic images

Christian Klose, Alexander Klose, Uwe Netz, Alexander Scheel, Jurgen Beuthan, Andreas Hielscher

JBO, Vol. 15, Issue 06, 066020, (November 2010) https://doi.org/10.1117/12.10.1117/1.3516705

KEYWORDS: Tomography, Magnetic resonance imaging, Neurons, Absorption, Biomedical optics, Image classification, Statistical analysis, Neural networks, Computer aided diagnosis and therapy, Optical inspection

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SPIE Journal Paper | 1 March 2009 Open Access

Registration of planar bioluminescence to magnetic resonance and x-ray computed tomography images as a platform for the development of bioluminescence tomography reconstruction algorithms

Bradley Beattie, Alexander Klose, Carl Le, Valerie Longo, Konstantine Dobrenkov, Jelena Vider, Jason Koutcher, Ronald Blasberg

JBO, Vol. 14, Issue 02, 024045, (March 2009) https://doi.org/10.1117/12.10.1117/1.3120495

KEYWORDS: Bioluminescence, Cameras, 3D image processing, Computed tomography, Image registration, Imaging systems, Magnetism, Reconstruction algorithms, Magnetic resonance imaging, Skin

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Proceedings Article | 24 February 2009 Paper

Frequency domain 3D simplified spherical harmonics approximation: development, validation, and implication in bioluminescence imaging

M. Chu, A. Klose, I. Styles, K. Vishwanath, H. Dehghani

Proceedings Volume 7174, 717422 (2009) https://doi.org/10.1117/12.808756

KEYWORDS: 3D modeling, Data modeling, Monte Carlo methods, Absorption, Spherical lenses, Optical properties, Bioluminescence, Photon transport, Diffusion, 3D image processing

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Proceedings Article | 24 February 2009 Paper

Implementation of the radiative transfer equation on block-structured grids for modeling fluorescence light propagation in tissue with arbitrary shape

Ludguier Montejo, Alexander Klose, Andreas Hielscher

Proceedings Volume 7174, 717410 (2009) https://doi.org/10.1117/12.810067

KEYWORDS: Luminescence, Radiative transfer, Tissue optics, Fluorescence tomography, Imaging systems, Modulation, Performance modeling, Solids, Radio propagation, Biomedical engineering

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Proceedings Article | 20 February 2009 Paper

Optical tomographic detection of rheumatoid arthritis with computer-aided classification schemes

Christian Klose, Alexander Klose, Uwe Netz, Jürgen Beuthan, Andreas Hielscher

Proceedings Volume 7171, 71710C (2009) https://doi.org/10.1117/12.809145

KEYWORDS: Magnetic resonance imaging, Tomography, Selenium, Gold, Image classification, Ultrasonography, Neurons, Absorption, Biomedical optics, Computer aided diagnosis and therapy

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SPIE Journal Paper | 1 September 2008 Open Access

Multiparameter classifications of optical tomographic images

Christian Klose, Alexander Klose, Uwe Netz, Juergen Beuthan, Andreas Hielscher

JBO, Vol. 13, Issue 05, 050503, (September 2008) https://doi.org/10.1117/12.10.1117/1.2981806

KEYWORDS: Image classification, Tomography, Absorption, Diagnostics, Scattering, Neurons, Laser scattering, Quantization, Optical tomography, Neural networks

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Proceedings Article | 7 March 2008 Paper

Multi-parameter optical image interpretations based on self-organizing mapping

Christian Klose, A. Klose, U. Netz, A. Scheel, J. Beuthan, Andreas Hielscher

Proceedings Volume 6850, 68500G (2008) https://doi.org/10.1117/12.763680

KEYWORDS: Gold, Magnetic resonance imaging, Neurons, Absorption, Scattering, Image classification, Laser scattering, Data modeling, Standards development, Tomography

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Proceedings Article | 13 February 2007 Paper

Stochastic image reconstruction in bioluminescence tomography with the equation of radiative transfer

Alexander Klose

Proceedings Volume 6434, 643405 (2007) https://doi.org/10.1117/12.699521

KEYWORDS: Image restoration, Stochastic processes, Tissues, Photons, Tissue optics, Bioluminescence, Tomography, Radiative transfer, Absorption, Image processing

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Proceedings Article | 13 March 2006 Paper

Functional imaging of small tissue volumes with diffuse optical tomography

Alexander Klose, Andreas Hielscher

Proceedings Volume 6143, 61431L (2006) https://doi.org/10.1117/12.659349

KEYWORDS: Tissue optics, Tumors, Absorption, Scattering, Tissues, Image restoration, Optical properties, Functional imaging, Diffusion, Light scattering

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Proceedings Article | 15 February 2006 Paper

Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging

J. Masciotti, F. Provenzano, J. Papa, A. Klose, J. Hur, X. Gu, D. Yamashiro, J. Kandel, A. Hielscher

Proceedings Volume 6081, 608105 (2006) https://doi.org/10.1117/12.647138

KEYWORDS: Tumors, Magnetic resonance imaging, Blood, Absorption, Kidney, Tomography, Optical tomography, Sensors, Neodymium, Optical imaging

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Proceedings Article | 15 October 2003 Paper

Assessment of finger joint inflammation by diffuse optical tomography

Andreas Hielscher, Alexander Klose, Alexander Scheel, Marina Backhaus, Uwe Netz, Juergen Beuthan

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.500770

KEYWORDS: Scattering, Inflammation, Tomography, Optical properties, Tissues, Geometrical optics, Optical imaging, Radiography, Magnetic resonance imaging, Image restoration

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Proceedings Article | 8 August 2003 Paper

Diffuse optical tomography: an emerging biomedical imaging modality

Andreas Hielscher, Gassan Abdoulaev, Alexander Klose, Avraham Bluestone, U. Netz, J. Beuthan, Joseph Lasker

Proceedings Volume 5123, (2003) https://doi.org/10.1117/12.517033

KEYWORDS: Tissues, Sensors, Scattering, Absorption, Brain, Modulation, Image restoration, Optical properties, Diffusion, Data modeling

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Proceedings Article | 29 July 2003 Paper

Optical fluorescence tomography with the equation of radiative transfer for molecular imaging

Alexander Klose, Andreas Hielscher

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478227

KEYWORDS: Tissue optics, Quantum efficiency, Absorption, Luminescence, Geometrical optics, Molecular imaging, Image restoration, Radiative transfer, Scattering, Tissues

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Proceedings Article | 29 July 2003 Paper

Modeling photon propagation in anisotropically scattering media with the equation of radiative transfer

Alexander Klose, Andreas Hielscher

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478228

KEYWORDS: Scattering, Scattering media, Collimation, Light scattering, Radiative transfer, Tissue optics, Anisotropy, Light, Diffusion, Tissues

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Proceedings Article | 29 July 2003 Paper

Optical tomographic brain imaging with diffusion and transport-theory-based algorithms

Andreas Hielscher, Gassan Abdoulaev, Avraham Bluestone, Joseph Lasker, Alexander Klose

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478232

KEYWORDS: Diffusion, Reconstruction algorithms, Head, Sensors, Image restoration, Data modeling, Optical properties, Tomography, Brain, Geometrical optics

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Proceedings Article | 29 June 2001 Paper

First investigations on the use of the system theory in tissue optics

Juergen Beuthan, Alexander Klose, Hans-Joachim Cappius, Uwe Netz, Andreas Hielscher

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434470

KEYWORDS: Tissue optics, Scattering, Light scattering, Calculus, Laser scattering, Point spread functions, Protactinium, Algorithm development, Diagnostics, Skin

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Proceedings Article | 29 June 2001 Paper

Hybrid approach for diffuse optical tomography combining evolution strategies and gradient techniques

Alexander Klose, Andreas Hielscher

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434484

KEYWORDS: Optical properties, Sensors, Reconstruction algorithms, Diffuse optical tomography, Scattering, Image restoration, Optical tomography, Optimization (mathematics), Data modeling, Absorption

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Proceedings Article | 22 November 2000 Paper

Evolution-theory-based algorithm for optical diffusion tomography

Andreas Hielscher, Alexander Klose

Proceedings Volume 4160, (2000) https://doi.org/10.1117/12.407626

KEYWORDS: Reconstruction algorithms, Optical properties, Image restoration, Sensors, Optical tomography, Inverse optics, Tomography, Diffusion, Absorption, Scattering

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Proceedings Article | 6 June 2000 Paper

Quasi-Newton methods in iterative image reconstruction schemes for optical tomography

Alexander Klose, Andreas Hielscher, Juergen Beuthan

Proceedings Volume 3979, (2000) https://doi.org/10.1117/12.387641

KEYWORDS: Image restoration, Scattering, Optical tomography, Optical properties, Data modeling, Berkelium, Near infrared, Image quality, Reconstruction algorithms, Tissues

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Proceedings Article | 15 July 1999 Paper

Transport-theory-based reconstruction algorithm for optical tomography

Alexander Klose, Andreas Hielscher

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356841

KEYWORDS: Scattering, Sensors, Reconstruction algorithms, Optical properties, Optical tomography, Diffusion, Absorption, Image restoration, Radiative transfer, Scattering media

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Proceedings Article | 15 July 1999 Paper

Use of a priori information and penalty terms in gradient-based iterative reconstruction schemes

Andreas Hielscher, Alexander Klose

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356847

KEYWORDS: Optical properties, Image restoration, Sensors, Reconstruction algorithms, Diffusion, Tissues, Optical tomography, Data modeling, Absorption, Signal to noise ratio

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