Andreas Mandelis is a Full Professor of Mechanical and Industrial Engineering; Electrical and Computer Engineering; and the Institute of Biomaterials and Biomedical Engineering, University of Toronto. He has been the Chairman and CTO of Photo-Thermal Diagnostics, Inc., Toronto, ON, Canada. He is the President and CTO of Diffusion-Wave Diagnostic Technologies, Inc., Toronto, ON (www.diffusionwavetech.com), and the CTO of Quantum Dental Technologies, Inc., Toronto, ON (www.thecanarysystem.com). He was born in Kerkyra (Corfu), Greece. He received his BS degree (Magna cum Laude) in physics from Yale University in 1974, and MA, MSE, and Ph.D. degrees from the Applied Physics and Materials Laboratory, Department of Mechanical and Aerospace Engineering, Princeton University. He joined the electronics industry in the silicon Process R&D as a Member of Scientific Staff, Bell Northern Research Labs, Ottawa, in 1980-1981. He is the Director of the Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT) at the University of Toronto. He is the author and co-author of more than 370 scientific papers in refereed journals and 190 scientific and technical proceedings papers. He was the Editor-in-Chief of the book series Progress in Photothermal and Photoacoustic Science and Technology, published by the Society for Optical Engineering (SPIE). He has also been a guest editor of a number of special issues in the area of photoacoustic/photothermal and generally, diffusion-wave phenomena. He is Editor-in-Chief of the Springer International Journal of Thermophysics, an Associate Editor of the AIP Journals Review of Scientific Instruments and Journal of Applied Physics, Topical Editor of the OSA Journal Optics Letters and of the SPIE Journal of Biomedical Optics. He also is Consulting Editor of the AIP flagship magazine Physics Today. He has several inventions, more than 25 patents and patents pending.
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Intravascular photoacoustics (IV-PA) is an emerging atherosclerosis imaging modality that provides chemical-specific optical information of arterial walls with acoustic depth penetration and resolution. As lipid composition of atherosclerotic plaques is considered to be one of the primary indicators for plaque vulnerability, many IV-PA applications are calibrated so as to target plaque necrotic cores. Based on the mode of optical excitation and the corresponding signal processing technique, IV-PA is categorized into two different modalities. The pulse-based IV-PA has been the universal IV-PA imaging mode with its high peak power and straightforward time-domain signal processing technique. As an alternative, the low power continuous-wave (CW)-based IV-PA has been under intense development as a radar-like frequency-domain signal processing modality. The two state-of-the-art types of IV-PA are reviewed in terms of their physics and imaging capabilities, with major emphasis on frequency-swept CW-based IV-PA that has been recently introduced in the field.
Minute changes in total hemoglobin concentration (tHb) and oxygenation levels are detectable using this method since background absorption is suppressed due to the out-of-phase modulation of the laser sources while the difference between the two signals is amplified, thus allowing pre-malignant tumors to become identifiable. By regulating the signal amplitude ratio and phase shift the system can be tuned to applications like cancer screening, sO2 quantification and hypoxia monitoring in stroke patients. Experimental results presented demonstrate WM-DPA imaging of sheep blood phantoms in comparison to single-wavelength FD-PAR imaging. Future work includes the functional PA imaging of small animals in vivo.
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