Prof. Arnaud Dubois Profile

Prof. Arnaud Dubois

Teacher/Researcher at Lab Charles Fabry

SPIE Involvement:

Author

Publications (53)

Proceedings Article | 22 August 2023 Paper

Advances of LC-OCT technology for diagnostic support in dermatology

F. Latriglia, J. Ogien, S. Fischman, M. Pedrazzani, A. Dubois

Proceedings Volume 12627, 126271M (2023) https://doi.org/10.1117/12.2670911

KEYWORDS: Diagnostics, Skin, Dermatology, Image segmentation, Tissues, Pathology, Optical coherence tomography, Confocal microscopy, Visualization, Tissue optics

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Proceedings Article | 11 August 2023 Paper

A platform prototype for co-localized line-field confocal optical coherence tomography (LC-OCT) and confocal Raman microspectroscopy (CRM) acquisitions on ex vivo skin tissues

Léna Waszczuk, Jonas Ogien, Ali Tfayli, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 12632, 1263210 (2023) https://doi.org/10.1117/12.2672229

KEYWORDS: Confocal microscopy, Skin, Raman spectroscopy, Prototyping, Optical coherence tomography, Imaging spectroscopy, Tissues, Surgery, Skin cancer, In vivo imaging

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Proceedings Article | 11 August 2023 Paper

Combined line-field confocal optical coherence tomography (LC-OCT) and dermoscopy for in vivo human skin imaging

Jonas Ogien, Olivier Levecq, Anthony Daures, Arnaud Dubois

Proceedings Volume 12632, 126320F (2023) https://doi.org/10.1117/12.2671717

KEYWORDS: Skin, Optical coherence tomography, Confocal microscopy, In vivo imaging, Imaging systems, 3D image processing, Target acquisition, Reflectivity, Real time imaging, Optical properties

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SPIE Journal Paper | 13 August 2022 Open Access

Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

Weikai Xue, Jonas Ogien, Pavel Bulkin, Anne-Lise Coutrot, Arnaud Dubois

JBO, Vol. 27, Issue 08, 086002, (August 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.8.086002

KEYWORDS: 3D image processing, Cameras, Skin, Confocal microscopy, Reflectivity, Mirrors, Mirau interferometers, Optical coherence tomography, Image resolution, 3D acquisition

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Significance: Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced high-resolution imaging modality based on a combination of low-coherence optical interferometry and reflectance confocal optical microscopy with line illumination and line detection. Capable of producing three-dimensional (3D) images of the skin with cellular resolution, in vivo, LC-OCT has been mainly applied in dermatology and dermo-cosmetology. The LC-OCT devices capable of acquiring 3D images reported so far are based on a Linnik interferometer using two identical microscope objectives. In this configuration, LC-OCT cannot be designed to be a very compact and light device, and the image acquisition speed is limited.Aim: The objective of this work was to develop a more compact and lighter LC-OCT device that is capable of acquiring images faster without significant degradation of the resolution and with optimized detection sensitivity.Approach: We developed an LC-OCT device based on a Mirau interferometer using a single objective. Dynamic adjustment of the camera frequency during the depth scan is implemented, using a faster camera and a more powerful light source. The reflectivity of the beam-splitter in the Mirau interferometer was optimized to maximize the detection sensitivity. A galvanometer scanner was incorporated into the device for scanning the illumination line laterally. A stack of adjacent B-scans, constituting a 3D image, can thus be acquired.Results: The device is able to acquire and display B-scans at 17 fps. 3D images with a quasi-isotropic resolution of ∼1.5 μm (1.3, 1.9, and 1.1 μm in the x , y, and z directions, respectively) over a field of 940 μm × 600 μm × 350 μm (x × y × z) can be obtained. 3D imaging of human skin at cellular resolution, in vivo, is reported.Conclusions: The acquisition rate of the B-scans, at 17 fps, is unprecedented in LC-OCT. Compared with the conventional LC-OCT devices based on a Linnik interferometer, the reported Mirau-based LC-OCT device can acquire B-scans ∼2 times faster. With potential advantages in terms of compactness and weight, a Mirau-based device could easily be integrated into a smaller and lighter handheld probe for use by dermatologists in their daily medical practice.

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Proceedings Article | 7 March 2022 Presentation + Paper

Optical skin biopsy using multimodal line-field confocal optical coherence tomography (LC-OCT)

Jonas Ogien, Léna Waszczuk, Mariano Suppa, Véronique del Marmol, Josep Malvehy, Elisa Cinotti, Pietro Rubegni, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 11948, 1194806 (2022) https://doi.org/10.1117/12.2612808

KEYWORDS: Skin, Confocal microscopy, Optical coherence tomography, Raman spectroscopy, Biopsy, 3D image processing, Tissue optics, Skin cancer, Microscopes

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Proceedings Article | 7 March 2022 Poster + Paper

Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

Weikai Xue, Jonas Ogien, Pavel Bulkin, Anne-Lise Coutrot, Arnaud Dubois

Proceedings Volume 11948, 119480G (2022) https://doi.org/10.1117/12.2608747

KEYWORDS: Skin, 3D acquisition, 3D image processing, Optical coherence tomography, Cameras, Mirrors, Objectives, Image resolution, Confocal microscopy, Mirau interferometers, Dermatology, Oncology, Optical interferometry, Optical coherence microscopy

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Proceedings Article | 3 March 2022 Presentation + Paper

Morpho-molecular characterization of a tattooed skin biopsy using co-localized line-field confocal optical coherence tomography (LC-OCT) and confocal Raman microspectroscopy

Léna Waszczuk, Jonas Ogien, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 11934, 1193403 (2022) https://doi.org/10.1117/12.2607277

KEYWORDS: Raman spectroscopy, Skin, Biopsy, Confocal microscopy, 3D image processing, Optical coherence tomography, Imaging spectroscopy, Particles, 3D acquisition, Tissue optics

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Proceedings Article | 3 March 2022 Presentation + Paper

Three-dimensional microscopic quantification of in vivo healthy epidermis based on line-field confocal optical coherence tomography (LC-OCT) assisted by artificial intelligence

Jonas Ogien, Julie Chauvel-Picard, Vincent Bérot, Linda Tognetti, Carmen Orte Cano, Margot Fontaine, Clément Lenoir, Javiera Pérez-Anker, Susana Puig, Arnaud Dubois, Sandra Forestier, Jilliana Monnier, Randa Jdid, Gabriel Cazorla, Mélanie Pedrazzani, Antoine Sanchez, Sébastien Fischman, Pietro Rubegni, Véronique del Marmol, Josep Malvehy, Elisa Cinotti, Jean-Luc Perrot, Mariano Suppa

Proceedings Volume 11934, 1193409 (2022) https://doi.org/10.1117/12.2607344

KEYWORDS: Skin, Image segmentation, 3D modeling, 3D image processing, In vivo imaging, Optical coherence tomography, Artificial intelligence, Confocal microscopy, 3D acquisition

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Proceedings Article | 3 March 2022 Poster + Paper

Line-field confocal optical coherence tomography (LC-OCT) for ex-vivo skin imaging with extended field-of-view

Jonas Ogien, Jean-Luc Perrot, Anthony Daures, Alexis Sourp, Olivier Levecq, Arnaud Dubois

Proceedings Volume 11934, 119340I (2022) https://doi.org/10.1117/12.2607348

KEYWORDS: Skin, 3D image processing, Biopsy, Optical coherence tomography, Imaging systems, Confocal microscopy, In vivo imaging, Surgery, Visualization

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Proceedings Article | 3 March 2022 Paper

Measurement of optical scattering properties using line-field confocal optical coherence tomography (LC-OCT)

Léna Waszczuk, Jonas Ogien, Frédéric Pain, Arnaud Dubois

Proceedings Volume 11974, 1197404 (2022) https://doi.org/10.1117/12.2607279

KEYWORDS: Scattering, 3D image processing, Optical properties, Integrating spheres, Collimation, 3D metrology, Optical coherence tomography, Tissues, Light scattering, Confocal microscopy

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Proceedings Article | 2 March 2022 Poster + Paper

Co-localized line-field confocal optical coherence tomography (LC-OCT) and confocal Raman microspectroscopy for ex vivo analysis of skin tissues

Léna Waszczuk, Jonas Ogien, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 11952, 119520D (2022) https://doi.org/10.1117/12.2607278

KEYWORDS: Raman spectroscopy, Skin, 3D image processing, Confocal microscopy, Optical coherence tomography, Calibration, 3D acquisition, Tissues, In vivo imaging, Imaging spectroscopy

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Proceedings Article | 1 April 2020 Presentation + Paper

Line-field confocal optical coherence tomography: technology and application in dermatology

Jonas Ogien, Olivier Levecq, Hicham Azimani, David Siret, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 11359, 113590F (2020) https://doi.org/10.1117/12.2554400

KEYWORDS: Optical coherence tomography, Skin, Dermatology, Image resolution, Confocal microscopy, Spatial resolution, Technologies and applications

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Proceedings Article | 30 March 2020 Presentation + Paper

Line-field confocal optical coherence tomography based on a Mirau interferometer

Weikai Xue, Jonas Ogien, Olivier Levecq, Arnaud Dubois

Proceedings Volume 11351, 113511O (2020) https://doi.org/10.1117/12.2555691

KEYWORDS: Optical coherence tomography, Mirau interferometers, Skin, Confocal microscopy, Objectives, Image resolution, Mirrors, Interferometers, Microscopes

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Proceedings Article | 21 February 2020 Paper

Switchable vertical/horizontal section imaging with line-field confocal optical coherence tomography

Jonas Ogien, Olivier Levecq, Hicham Azimani, Arnaud Dubois

Proceedings Volume 11228, 1122816 (2020) https://doi.org/10.1117/12.2547454

KEYWORDS: Optical coherence microscopy, Skin, Optical coherence tomography, Imaging systems, Interferometers, In vivo imaging, Confocal microscopy, Image resolution, Microscopes

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Proceedings Article | 19 February 2020 Paper

Video-mosaicking of human skin in vivo using handheld line-field confocal optical coherence tomography

Jonas Ogien, Anthony Daures, Maxime Cazalas, Olivier Levecq, Arnaud Dubois

Proceedings Volume 11211, 1121114 (2020) https://doi.org/10.1117/12.2544897

KEYWORDS: Skin, In vivo imaging, Imaging systems, Video, Optical coherence tomography, Confocal microscopy, Image processing, Tumors, Video processing, Optical coherence microscopy

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Proceedings Article | 19 February 2020 Paper

Handheld line-field confocal optical coherence tomography for dermatology

Jonas Ogien, Olivier Levecq, Maxime Cazalas, Mariano Suppa, Véronique del Marmol, Josep Malvehy, Elisa Cinotti, Pietro Rubegni, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 11211, 112110S (2020) https://doi.org/10.1117/12.2545546

KEYWORDS: Optical coherence microscopy, Skin, Optical coherence tomography, Skin cancer, Confocal microscopy, Dermatology, In vivo imaging, Biopsy, Image resolution, Microscopes

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Proceedings Article | 4 March 2019 Paper

Line-field confocal optical coherence tomography operating simultaneously at 800 nm and 1300 nm center wavelengths

Arthur David, Olivier Levecq, Hicham Azimani, David Siret, Arnaud Dubois

Proceedings Volume 10890, 108902I (2019) https://doi.org/10.1117/12.2508465

KEYWORDS: Image fusion, Cameras, Optical coherence tomography, Image resolution, Microscopes, Skin, Confocal microscopy

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Proceedings Article | 26 February 2019 Paper

Skin lesion imaging with line-field confocal optical coherence tomography

Maxime Cazalas, Olivier Levecq, Hicham Azimani, David Siret, Anaïs Barut, Marianno Suppa, Véronique del Marmol, Josep Malvehy, Elisa Cinotti, Pietro Rubegni, Jean Luc Perrot, Arnaud Dubois

Proceedings Volume 10851, 108510M (2019) https://doi.org/10.1117/12.2508484

KEYWORDS: Optical coherence tomography, Skin, Confocal microscopy, Image resolution, In vivo imaging, Microscopes, Dermatology, Skin cancer, Tissues

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Proceedings Article | 22 February 2019 Paper

Line-field confocal optical coherence tomography

Jonas Ogien, Olivier Levecq, Hicham Azimani, Arthur David, Weikai Xue, David Siret, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 10867, 108670U (2019) https://doi.org/10.1117/12.2507244

KEYWORDS: Optical coherence tomography, Confocal microscopy, Skin, Image resolution, Microscopes, Objectives, In vivo imaging, Interferometers, Light scattering

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SPIE Journal Paper | 23 October 2018 Open Access

Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors

Arnaud Dubois, Olivier Levecq, Hicham Azimani, David Siret, Anaïs Barut, Mariano Suppa, Véronique del Marmol, Josep Malvehy, Elisa Cinotti, Pietro Rubegni, Jean-Luc Perrot

JBO, Vol. 23, Issue 10, 106007, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.10.106007

KEYWORDS: Skin, Optical coherence tomography, Confocal microscopy, Microscopes, Tumors, Image resolution, Tissue optics, Tissues, Melanoma, Glasses

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Proceedings Article | 24 May 2018 Paper

Advances in optical coherence tomography for dermatology

Olivier Levecq, Arthur Davis, Hicham Azimani, David Siret, Jean-Luc Perrot, Arnaud Dubois

Proceedings Volume 10677, 106770K (2018) https://doi.org/10.1117/12.2315765

KEYWORDS: Optical coherence tomography, Skin, Microscopes, Interferometry, Dermatology, Cameras, In vivo imaging, Image resolution, Tomography, Microscopy

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Proceedings Article | 17 February 2017 Paper

Speckle variance full-field optical coherence microscopy for high-resolution microvasculature mapping

Jonas Ogien, Arnaud Dubois

Proceedings Volume 10053, 100532O (2017) https://doi.org/10.1117/12.2254836

KEYWORDS: Functional imaging, Optical coherence tomography, Speckle, Optical coherence microscopy, Medical imaging, Microscopy, Capillaries, Tomography, Liquids, Interferometry, Reflectivity, Cameras

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Proceedings Article | 17 February 2017 Paper

Compact LED-based full-field optical coherence microscopy for high-resolution high-speed in vivo imaging

Jonas Ogien, Arnaud Dubois

Proceedings Volume 10053, 100532M (2017) https://doi.org/10.1117/12.2254347

KEYWORDS: In vivo imaging, Light emitting diodes, Optical coherence microscopy, Optical coherence tomography, Medical imaging, Microscopy, Interferometry, Skin, Image quality, Light sources, Imaging systems, Tomography, Interferometers

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Proceedings Article | 11 June 2015 Paper

Full-field optical coherence tomography for tissue imaging

A. Dubois

Proceedings Volume 9531, 953107 (2015) https://doi.org/10.1117/12.2186645

KEYWORDS: Tissues, Optical coherence tomography, Microscopes, Cameras, Interferometry, Confocal microscopy, Objectives, Tissue optics, Tomography, Spatial resolution

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Proceedings Article | 8 May 2014 Paper

Color high resolution full-field optical coherence microscopy for contrast-enhanced imaging

A. Federici, A. Dubois

Proceedings Volume 9129, 91290N (2014) https://doi.org/10.1117/12.2053850

KEYWORDS: Imaging systems, Image resolution, RGB color model, Microscopes, Dispersion, Cameras, Reflectivity, Tomography, Interferometry, Optical coherence tomography

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Proceedings Article | 22 February 2013 Paper

Towards STED microscopy with nanometric optical sectioning

Siddharth Sivankutty, Thomas Barroca, Guillaume Dupuis, Christophe Lefumeux, Céline Mayet, Arnaud Dubois, Catherine Marquer, Sandrine Lécart, Marie-Claude Potier, Emmanuel Fort, Sandrine Lévêque-Fort

Proceedings Volume 8590, 859018 (2013) https://doi.org/10.1117/12.2004883

KEYWORDS: Stimulated emission depletion microscopy, Microscopes, Microscopy, Confocal microscopy, Optical microscopy, Interfaces, Super resolution, Imaging systems, Image resolution, Molecules

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Proceedings Article | 8 May 2012 Paper

Guiding glaucoma laser surgery using Fourier-domain optical coherence tomography at 1.3 µm

Masreshaw Bayleyegn, Houssine Makhlouf, Caroline Crotti, Karsten Plamann, Arnaud Dubois

Proceedings Volume 8427, 84271E (2012) https://doi.org/10.1117/12.922617

KEYWORDS: Optical coherence tomography, Cornea, Laser therapeutics, Surgery, Imaging systems, Eye, Femtosecond phenomena, Laser cutting, Optic nerve, Sclera

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Proceedings Article | 18 May 2010 Paper

Full-field optical coherence tomography at 800 nm and 1300 nm simultaneously

Delphine Sacchet, Julien Moreau, Patrick Georges, Arnaud Dubois

Proceedings Volume 7715, 77152V (2010) https://doi.org/10.1117/12.853064

KEYWORDS: Cameras, Optical coherence tomography, Indium gallium arsenide, Silicon, Water, Spectroscopy, Imaging systems, Imaging spectroscopy, Microscopes, Tomography

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Proceedings Article | 15 May 2010 Paper

Study and suppression of motion artifacts in full-field optical coherence tomography

Delphine Sacchet, Julien Moreau, Patrick Georges, Arnaud Dubois

Proceedings Volume 7715, 77150A (2010) https://doi.org/10.1117/12.853029

KEYWORDS: Tomography, Cameras, Phase shifts, Microscopes, Optical coherence tomography, Luminescence, Interferometry, Objectives, Crystals, Mirrors

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Proceedings Article | 14 July 2009 Paper

Multi-band ultrahigh resolution full-field optical coherence tomography

Delphine Sacchet, Julien Moreau, Patrick Georges, Arnaud Dubois

Proceedings Volume 7372, 73721F (2009) https://doi.org/10.1117/12.831827

KEYWORDS: Cameras, Water, Optical coherence tomography, Indium gallium arsenide, Silicon, Microscopes, Halogens, Lamps, Absorption, Tomography

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Proceedings Article | 8 October 2007 Paper

Full-field optical coherence tomography (OCT) and early alterations in chloroplast morphology

A. C. Boccara, R. De Paepe, A. Dubois, M. Boccara

Proceedings Volume 6755, 67550E (2007) https://doi.org/10.1117/12.731318

KEYWORDS: Optical coherence tomography, Confocal microscopy, Backscatter, Biomedical optics, Scattering, Tissues, Scattering media, Microscopes, Luminescence, Mirrors

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Proceedings Article | 7 March 2006 Paper

Anterior segment imaging in vivo in rats and ex vivo in mice using fullfield optical coherence tomography

Kate Grieve, Petr Kuchynka, Manuel Simonutti, Arnaud Dubois, Jean-François Le Gargasson, Albert Claude Boccara

Proceedings Volume 6138, 61380D (2006) https://doi.org/10.1117/12.644540

KEYWORDS: Optical coherence tomography, In vivo imaging, Eye, Image segmentation, Cornea, Scattering, 3D image processing, Image resolution, Lamps, Tomography

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Proceedings Article | 7 October 2005 Paper

In vivo and ex vivo imaging with ultrahigh resolution full-field OCT

Kate Grieve, Gael Moneron, Wilfrid Schwartz, Albert Boccara, Arnaud Dubois

Proceedings Volume 5861, 586113 (2005) https://doi.org/10.1117/12.632997

KEYWORDS: Optical coherence tomography, In vivo imaging, Image resolution, Ophthalmology, Interferometers, Light sources, Microscopy, Tissues, Imaging systems, Detector arrays

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Proceedings Article | 18 April 2005 Paper

Full-field OCT: applications in ophthalmology

Katharine Grieve, Arnaud Dubois, Michel Paques, Jean-François Le Gargasson, Albert Boccara

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.588649

KEYWORDS: Optical coherence tomography, Imaging systems, Tissues, Image segmentation, Cornea, Image resolution, Retina, In vivo imaging, Ophthalmology, Lamps

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Proceedings Article | 15 April 2005 Paper

Monitoring cell profile in tissue engineered constructs by OCT

Ying Yang, Pierre Bagnaninchi, Mairead Wood, Alicia El Haj, Elvire Guyot, Arnaud Dubois, Ruikang Wang

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.592752

KEYWORDS: Optical coherence tomography, Tissues, Tissue engineering, Tissue optics, Bone, Polymers, Nondestructive evaluation, Proteins, Biological research, Magnetic resonance imaging

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Proceedings Article | 13 April 2005 Paper

Ultrahigh-resolution optical imaging of cellular structures of high-scattering biological tissues with whole-field optical coherence microcopy

Ruikang Wang, Ying Yang, Elvire Guyot, Arnaud Dubois

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592671

KEYWORDS: Optical coherence tomography, Tissues, Imaging systems, Image resolution, Scattering, Optical imaging, Cartilage, Biomedical optics, Coherence (optics), Tissue optics

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Proceedings Article | 13 April 2005 Paper

Full-field OCT: ex vivo and in vivo biological imaging applications

Katharine Grieve, Arnaud Dubois, Gael Moneron, Elvire Guyot, Albert Boccara

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.589651

KEYWORDS: Optical coherence tomography, Imaging systems, In vivo imaging, CCD cameras, Microscopes, Tomography, Objectives, Image resolution, Interferometers, Ophthalmology

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Proceedings Article | 13 April 2005 Paper

Application of optical coherence tomography for tissue engineering

Ying Yang, Ruikang Wang, Elvire Guyot, Alicia El Haj, Arnaud Dubois

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592691

KEYWORDS: Optical coherence tomography, Tissue engineering, Tissues, Bone, Tissue optics, Polymers, Magnetism, Nondestructive evaluation, Michelson interferometers, Imaging systems

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Proceedings Article | 24 March 2005 Paper

Three-dimensional multiple nanometric local probes microscopy

Gael Moneron, Arnaud Dubois, Albert Claude Boccara

Proceedings Volume 5701, (2005) https://doi.org/10.1117/12.588667

KEYWORDS: Microscopy, 3D image processing, Near field scanning optical microscopy, Scanning tunneling microscopy, Microscopes, Gold, Optical coherence tomography, Image resolution, Diffraction, Interferometers

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Proceedings Article | 24 March 2005 Paper

Tomographic imagery by interference microscopy

Arnaud Dubois, Elvire Guiot, Wilfrid Schwartz, Gael Moneron, Kate Grieve, Claude Boccara

Proceedings Volume 5701, (2005) https://doi.org/10.1117/12.586727

KEYWORDS: Optical coherence tomography, Tomography, Microscopes, Tissues, 3D image processing, Microscopy, Mirrors, Coherence (optics), Objectives, Biology

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Proceedings Article | 29 July 2004 Paper

Full-field optical coherence microscopy

Arnaud Dubois, Katharine Grieve, Gael Moneron, Albert-Claude Boccara

Proceedings Volume 5486, (2004) https://doi.org/10.1117/12.571464

KEYWORDS: Optical coherence tomography, Microscopes, Tomography, Objectives, Image segmentation, Image resolution, Interferometers, CCD cameras, Mirrors, Optical coherence microscopy

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Proceedings Article | 13 July 2004 Paper

Three-dimensional imagery using multiple nanometric probes

Gael Moneron, Arnaud Dubois, Albert-Claude Boccara

Proceedings Volume 5324, (2004) https://doi.org/10.1117/12.529274

KEYWORDS: Particles, Microscopes, 3D image processing, Diffraction, 3D acquisition, Light scattering, Microscopy, Charge-coupled devices, Scattering, Multiple scattering

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Proceedings Article | 1 July 2004 Paper

Ultrashort acquisition time full-field OCT

Kate Grieve, Arnaud Dubois, Albert Boccara

Proceedings Volume 5316, (2004) https://doi.org/10.1117/12.529193

KEYWORDS: Optical coherence tomography, Imaging systems, CCD cameras, Microscopes, Cameras, In vivo imaging, Image resolution, Signal detection, Signal to noise ratio, Reflectivity

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Proceedings Article | 16 June 2004 Paper

Two- and three-dimensional near-field microscopy using scattering probes

Gael Moneron, Laurent Williame, Arnaud Dubois, Samuel Gresillon, Albert Boccara

Proceedings Volume 5327, (2004) https://doi.org/10.1117/12.529298

KEYWORDS: Near field scanning optical microscopy, Particles, Near field optics, Near field, Scattering, Gold, 3D image processing, Optical spheres, Microscopy, Microscopes

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Proceedings Article | 2 October 2003 Paper

High-resolution three-dimensional imaging inside biological media using white-light interference microscopy

Arnaud Dubois, Gael Moneron, Kate Grieve, Albert Boccara

Proceedings Volume 5140, (2003) https://doi.org/10.1117/12.497723

KEYWORDS: Optical coherence tomography, Microscopes, Image resolution, Tomography, Tissues, Mirrors, Interferometers, Objectives, Reflectivity, 3D image processing

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Proceedings Article | 9 July 2003 Paper

High-resolution three-dimensional imaging using multiple nanometric probes

Arnaud Dubois, Gael Moneron, Romain Lecaque, Francois Lequeux, Albert-Claude Boccara

Proceedings Volume 4964, (2003) https://doi.org/10.1117/12.477973

KEYWORDS: Particles, Microscopes, 3D image processing, Charge-coupled devices, Signal to noise ratio, Diffraction, Light scattering, Microscopy, Mirrors, Light

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Proceedings Article | 8 July 2003 Paper

Ultrahigh-resolution OCT using white-light interference microscopy

Arnaud Dubois, Laurent Vabre, Romain Lecaque, Albert-Claude Boccara

Proceedings Volume 4956, (2003) https://doi.org/10.1117/12.477631

KEYWORDS: Optical coherence tomography, Image resolution, Microscopes, Tissues, Tomography, Microscopy, Interferometers, CCD cameras, Objectives, Mirrors

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Proceedings Article | 23 October 2001 Paper

Phase-shifting interference microscope for the characterization of metallic interconnections of flat panel displays

Pierre Boher, Jean-Philippe Piel, Jean-Louis Stehle, Arnaud Dubois, Albert Boccara

Proceedings Volume 4447, (2001) https://doi.org/10.1117/12.446735

KEYWORDS: Flat panel displays, Phase shifts, Glasses, Microscopes, Phase shift keying, Reflection, Metals, Phase modulation, Modulation, Refractive index

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Proceedings Article | 22 November 2000 Paper

Optical coherence microscopy for high-resolution biological imaging

Laurent Vabre, Arnaud Dubois, Emmanuel Beaurepaire, Albert Boccara

Proceedings Volume 4160, (2000) https://doi.org/10.1117/12.407632

KEYWORDS: Microscopes, Objectives, Tissues, Optical coherence tomography, Modulation, Image resolution, Tomography, Light emitting diodes, Optical coherence microscopy, CCD cameras

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Proceedings Article | 19 July 1999 Paper

Imaging through scattering media using cameras and parallel processing

Sandrine Leveque, Arnaud Dubois, Emmanuel Beaurepaire, Loic Pottier, Albert Boccara, Martial Lebec, Herve Saint-Jalmes

Proceedings Volume 3749, (1999) https://doi.org/10.1117/12.354984

KEYWORDS: Photons, Scattering media, Parallel processing, Sensors, Signal to noise ratio, Biomedical optics, Modulation, Cameras, Signal processing, Tissues

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Proceedings Article | 15 July 1999 Paper

3D imaging in biological tissues by tagging photon paths with ultrasound

Sandrine Leveque, Albert Boccara, Emmanuel Beaurepaire, Arnaud Dubois, Martial Lebec, Herve Saint-Jalmes

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356827

KEYWORDS: Modulation, Speckle, Signal detection, Ultrasonics, CCD cameras, Tissues, Transducers, CCD image sensors, Ultrasonography, Signal to noise ratio

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Proceedings Article | 6 May 1999 Paper

High-resolution real-time full-field interference microscopy

Arnaud Dubois, Martial Lebec, Emmanuel Beaurepaire, Sandrine Leveque, Albert Boccara

Proceedings Volume 3605, (1999) https://doi.org/10.1117/12.347563

KEYWORDS: Microscopes, Objectives, Lenses, Light emitting diodes, Integrated circuits, Autoregressive models, Microscopy, 3D image processing, Mirrors, Silicon

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Proceedings Article | 13 October 1994 Paper

Perylene, pyrromethene and grafted rhodamine-doped xerogels for tunable solid state laser

Michael Canva, Arnaud Dubois, Patrick Georges, Alain Brun, Frederic Chaput, Agnes Ranger, Jean-Pierre Boilot

Proceedings Volume 2288, (1994) https://doi.org/10.1117/12.188963

KEYWORDS: Rhodamine B, Matrices, Molecules, Solid state lasers, Energy efficiency, Nd:YAG lasers, Molecular lasers, Silica, Luminescence, Polishing

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Organic dye molecules have been widely used in solution as amplifying media in tunable lasers. The possibility of trapping these molecules in a solid state matrix may lead to a new field of application outside the laboratory. Many types of matrices can be used. We present results with new hybrid organic/inorganic xerogels prepared by hydrolysis-condensation of the methyl- or vinyl-triethoxysilane precursor under acid-catalyzed hydrolysis and basic-catalyzed condensation. Organic methyl or vinyl groups attached to the silica network provide a favorable environment to dye fluorescence. We have studied the effect induced by using different basic catalysts: N-(2-aminoethyl)-3-aminopropyltrimethoxysilane and 3- aminopropyltriethoxysilane are found to lead to the best matrix characteristics. Perylenes and pyrromethenes were chosen because of their thermal- and photo-stability. After gelation, 10 mm thick samples, polished to a surface roughness of about 4 nm, are placed in a plano- concave cavity as gain media and pumped by a frequency doubled nanosecond Q:switched Nd:YAG laser. Efficiency is the greatest with a pyrromethene 597 doped sample: more than 6 mJ output energy for a 10 mJ pump energy (2 J/cm² fluence) leading to a slope efficiency of 63%. The lifetime of the laser emission when the same point of the sample is sequentially used is also an important characteristic. Best results are obtained with perylene red dye: for a pump energy of 0.7 mJ at 1 Hz repetition rate, the output energy is still 50% of the initial value (0.1 mJ) after 80,000 shots. For a pyrromethene 597 doped MTEOS sample, it appears that the measured lifetimes are independent of the operating frequency in the 0.2 - 20 Hz range, indicating a reasonable heat conductivity for this type of matrix. We have also studied tunability by adding a grating or prism to the cavity: a typical tunability of over 50 nm or more is obtained with many of these dyes. Finally we report laser activity obtained with rhodamine B doped xerogels in which the dye molecules were covalently bonded to the silica network in order to stabilize the organic molecule structure.

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Conference Committee Involvement (2)

Interferometry XVII: Techniques and Analysis

17 August 2014 | San Diego, California, United States

Interferometry XVI: Techniques and Analysis

13 August 2012 | San Diego, California, United States

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