Advanced-stage ovarian cancer becomes extremely challenging to treat effectively using current surgical and chemotherapy methods due to factors such as peritoneal metastasis, incomplete resection, and drug resistance. While photoimmunotherapy is emerging as a promising option for unresectable metastases, its full potential often goes unrealized due to varying treatment outcomes. This research effort aims to enhance the reliability, safety, and effectiveness of photoimmunotherapy for peritoneal metastases by combining targeted nanotechnology, fluorescence-guided intervention, and a state-of-the-art medical laser system.
Peritoneal metastasis, incomplete resection, and drug resistance render advanced-stage ovarian cancer virtually incurable with current surgical and chemotherapy approaches. Photoimmunotherapy is increasingly used to treat unresectable metastases, but many innovations are lost in translation due to heterogeneous treatment effects. This study integrates targeted nanotechnology, fluorescence-guided intervention, and a medical laser system to improve the safety, efficacy, and consistency of photoimmunotherapy for peritoneal metastases.
Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide, with 800,000 deaths per year. Since surgical options for HCC patients are limited, minimally invasive ablative therapies are critical to treat early-stage HCC; however, their cost and need for specialized equipment and expertise prevent widespread use in underprivileged populations. Here, we propose a lower-cost Light-Activatable, Sustained-exposure Ethanol Injection Technology (LASEIT) to augment current options for underprivileged patients.
This conference presentation was prepared for the Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI conference at SPIE BiOS, SPIE Photonics West 2023.
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