Claudio Bruschini is a Senior Scientist with 25+ years of R&D experience, with a broad background in sensing devices, including quantum photonic devices (in particular single-photon detectors) and applications thereof, such as biophotonics, basic sciences and engineering.
Claudio Bruschini received the Laurea degree in physics from the University of Genoa, Genoa, Italy, in 1992, and the Ph.D. degree in applied sciences from Vrije Universiteit Brussel, Brussels, Belgium, in 2002. He is currently a Scientist and Lab Deputy with EPFL’s Advanced Quantum Architecture Laboratory. His scientific interests have spanned from high energy physics and parallel computing in the early days, to challenging sensor applications in humanitarian demining, concentrating since 2003 on quantum photonic devices, high-speed and time-resolved 2D/3D optical sensing, as well as applications thereof (biophotonics, nuclear medicine, basic sciences, security, ranging). He has authored or co-authored over 130 articles and conference proceedings and one book; he was the co-recipient of the 2012 European Photonics Innovation Award, 2016 Swiss Medtech Award Finalist, and co-recipient of the Image Sensors Europe 2019 Award in the category "Best Academic Research Team". He is an SPIE and IEEE Senior Member and co-founder of one start-up to commercialise selected AQUA lab SPAD designs.
Claudio Bruschini received the Laurea degree in physics from the University of Genoa, Genoa, Italy, in 1992, and the Ph.D. degree in applied sciences from Vrije Universiteit Brussel, Brussels, Belgium, in 2002. He is currently a Scientist and Lab Deputy with EPFL’s Advanced Quantum Architecture Laboratory. His scientific interests have spanned from high energy physics and parallel computing in the early days, to challenging sensor applications in humanitarian demining, concentrating since 2003 on quantum photonic devices, high-speed and time-resolved 2D/3D optical sensing, as well as applications thereof (biophotonics, nuclear medicine, basic sciences, security, ranging). He has authored or co-authored over 130 articles and conference proceedings and one book; he was the co-recipient of the 2012 European Photonics Innovation Award, 2016 Swiss Medtech Award Finalist, and co-recipient of the Image Sensors Europe 2019 Award in the category "Best Academic Research Team". He is an SPIE and IEEE Senior Member and co-founder of one start-up to commercialise selected AQUA lab SPAD designs.
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Alternatively, single-photon avalanche diode (SPAD) imagers can provide even faster frame rates and zero readout noise. SwissSPAD is a 1-bit 512×128 SPAD imager, one of the largest of its kind, featuring a frame duration of 6.4 μs. Additionally, a gating mechanism enables photosensitive windows as short as 5 ns with a skew better than 150 ps across the entire array. The SwissSPAD photon detection efficiency (PDE) uniformity is very high, thanks on one side to a photon-to-digital conversion and on the other to a reduced fraction of "hot pixels" or "screamers", which would pollute the image with noise. A low native fill factor was recovered to a large extent using a microlens array, leading to a maximum PDE increase of 12×. This enabled us to detect single fluorophores, as required by ground state depletion followed by individual molecule return imaging microscopy (GSDIM). We show the first super resolution results obtained with a SPAD imager, with an estimated localization uncertainty of 30 nm and resolution of 100 nm. The high time resolution of 6.4 μs can be utilized to explore the dye's photophysics or for dye optimization. We also present the methodology for the blinking analysis on experimental data.
Fluorescence lifetime imaging to differentiate bound from unbound ICG-cRGD both in vitro and in vivo
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