The research of ultrafast dynamic processes needs the support of synchronization technology in the corresponding time scale. To use the THz pulse of China Academy of Engineering Physics Terahertz Free Electron Laser (CTFEL) and an external fs laser to study the ultrafast dynamic process with pump-probe technique needs the femtosecond-level synchronization between the two pulses. This letter introduces previous work and feasibility study of the synchronization method between THz and fs laser and obtains some experimental data for constructing the feedback compensation system. The experiment generates THz pulses by BNA/ZnTe crystal acting as accelerator-based THz light source for simulation, another fs laser pulse (split from the same fs laser, having a delay line to get different timing jitter.) will be modulated and detected to get the characterization using electro-optical sampling (EOS) and sum-frequency generation (SFG) and detection to give the feedback parameter.
China Academy of Engineering Physics Terahertz Free Electron Laser (CTFEL) has been commissioned in 2017 and provides 0.7~4.2 THz wave for users. In order to cover the frequency range of 0.1~0.7 THz, a super-radiation terahertz source is designed behind CTFEL. In this paper, design of the super-radiation source is reported. The super-radiation source works with MeVs and sub-picosecond electron bunch. The technical route to generate MeVs and sub-picosecond is as follows: the superconducting accelerator of CTFEL has two independent 4-cell cavities, the electron beam is accelerated in the first 4-cell cavity, and compressed in the second 4-cell cavity. The sub-picosecond electron beam travels through a undulator with a period of 58 mm to generate terahertz wave, and the gap of the undulator is adjusted to cover the frequency range of 0.1~0.7 THz. The theoretical calculation shows that average power of the super-radiation source can reach tens of Walt.
Non-thermal tumor ablation technology based on short pulse strong electric field can overcome the defects of thermal ablation and cryoablation, which provides a new opportunity for the development of tumor therapy. In this study, the CAEP terahertz free electron laser facility was preliminarily used to do the research on non-thermal tumor ablation method because of its unique macro-micro pulse time series. The biological effects of short pulse strong field terahertz radiation on melanoma cells and tissues were studied in vitro and in vivo. In vitro experiments show that the survival rate of tumor cells is significantly different after being irradiated by different frequency, power, and radiation duration of terahertz wave. Strong field terahertz wave can inhibit the proliferation of tumor cells. In vivo experiments showed that compared with the control group, the tumor tissue proliferation of the irradiated experimental group was slowed down, the tumor volume was gradually reduced, and the strong field terahertz pulses could inhibit the growth of tumor tissue. These preliminary results will provide a feasible reference for further research and long-term clinical application.
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