Time varying computer models of the interaction of laser light and tissue are very valuable in helping to understand
the complexity of the human body and biological tissue. The electrical property of tissue known as
permittivity is vital to accurately modeling the interaction of human tissue with lasers. Past laser and RF models
have represented the permittivity of the tissue as constant or temperature dependent. This paper presents time
dependent permittivity that changes as a result of tissue damage, temperature, blood flow, blood vessels, and
tissue property. The models are compared to emphasize the importance of accounting for these different tissue
properties. In particular, incorporating the time varying nature of the permittivity of human tissue into the
model leads to a significant change seen in tissue damage. An important feature of the model is the feedback
loop created between the permittivity, tissue damage, and temperature. The models focus on long time duration
applications where the time dependent changes significantly alter the results of the model. The applications for
these models lie mostly in the therapeutic area; however, the emphasized points are of consideration for any
computer model of the interaction of lasers and tissue.
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