Mr. Eric C. Soller Profile

Eric C. Soller

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Publications (7)

Proceedings Article | 13 July 2004 Paper

Composites containing albumin protein or cyanoacrylate adhesives and biodegradable scaffolds: I. Acute wound closure study in a rat model

Grant Hoffman, Eric Soller, Douglas Heintzelman, Mark Duffy, Jeffrey Bloom, Travis Gilmour, Krista Gonnerman, Karen McNally-Heintzelman

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.531991

KEYWORDS: Adhesives, Tissues, Proteins, Natural surfaces, Skin, Composites, Polymers, Semiconductor lasers, Indocyanine green, Laser welding

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Proceedings Article | 13 July 2004 Paper

Composites containing albumin protein or cyanoacrylate adhesives and biodegradable scaffolds: II. In vivo wound closure study in a rat model

Karen McNally-Heintzelman, Douglas Heintzelman, Mark Duffy, Jeffrey Bloom, Eric Soller, Travis Gilmour, Grant Hoffman, Deepak Edward

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.531997

KEYWORDS: Adhesives, Tissues, Wound healing, Proteins, Skin, Composites, Polymers, In vivo imaging, Semiconductor lasers, Laser welding

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Our Scaffold-Enhanced Biological Adhesive (SEBA) system was investigated as an alternative to sutures or adhesives alone for repair of wounds. Two scaffold materials were investigated: (i) a synthetic biodegradable material fabricated from poly(L-lactic-co-glycolic acid); and (ii) a biologic material, small intestinal submucosa, manufactured by Cook BioTech. Two adhesive materials were also investigated: (i) a biologic adhesive composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green dye mixed in deionized water, and activated with an 808-nm diode laser; and (ii) Ethicon’s Dermabond, a 2-octyl-cyanoacrylate. The tensile strength and time-to-failure of skin incisions repaired in vivo in a rat model were measured at seven days postoperative. Incisions closed by protein solder alone, by Dermabond alone, or by suture, were also tested for comparison. The tensile strength of repairs formed using the SEBA system were 50% to 65% stronger than repairs formed by suture or either adhesive alone, with significantly less variations within each experimental group (average standard deviations of 15% for SEBA versus 38% for suture and 28% for adhesive alone). In addition, the time-to-failure curves showed a longevity not previously seen with the suture or adhesive alone techniques. The SEBA system acts to keep the dermis in tight apposition during the critical early phase of wound healing when tissue gaps are bridged by scar and granulation tissue. It has the property of being more flexible than either of the adhesives alone and may allow the apposed edges to move in conjunction with each other as a unit for a longer period of time and over a greater range of stresses than adhesives alone. This permits more rapid healing and establishment of integrity since the microgaps between the dermis edges are significantly reduced. By the time the scaffolds are sloughed from the wound site, there is greater strength and healing than that produced by adhesive alone or by wounds following suture removal. This hypothesis is supported by the data of this study, as well as, the acute tensile strength data of Part I of this study.

Proceedings Article | 13 July 2004 Paper

A scaffold-enhanced light-activated surgical adhesive technique: surface selection for enhanced tensile strength in wound repair

Eric Soller, Grant Hoffman, Douglas Heintzelman, Mark Duffy, Jeffrey Bloom, Karen McNally-Heintzelman

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.532000

KEYWORDS: Tissues, Natural surfaces, Adhesives, Proteins, Scanning electron microscopy, Polymers, Intestine, Adsorption, Liver, Spleen

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Proceedings Article | 12 September 2003 Paper

Use of an infrared temperature monitoring system to determine optimal temperature for arterial repair using light-activated surgical adhesive

Eric Soller, Grant Hoffman, Karen McNally-Heintzelman

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.476388

KEYWORDS: Interfaces, Laser welding, Laser tissue interaction, Tissues, Proteins, Infrared imaging, Natural surfaces, Polymers, Infrared radiation, Chromophores

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Proceedings Article | 12 September 2003 Paper

Alternative chromophores for use in light-activated surgical adhesives: optimization of parameters for tensile strength and thermal damage profile

Grant Hoffman, Brian Byrd, Eric Soller, Douglas Heintzelman, Karen McNally-Heintzelman

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.476389

KEYWORDS: Chromophores, Interfaces, Laser tissue interaction, Laser welding, Proteins, Absorption, Semiconductor lasers, Polymers, Tissues, Adhesives

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Proceedings Article | 17 June 2002 Paper

Investigation of various synthetic polymer scaffolds for enhanced mechanical strength during laser tissue soldering

Grant Hoffman, Eric Soller, Jill Riley, Karen McNally-Heintzelman

Proceedings Volume 4609, (2002) https://doi.org/10.1117/12.432092

KEYWORDS: Polymers, Proteins, Tissues, Laser tissue interaction, Laser welding, Particles, Laser applications, Adhesives, Indocyanine green, Semiconductor lasers

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Proceedings Article | 17 June 2002 Paper

Comparison of light-activated surgical adhesive and suture techniques for vascular repair: an in-vivo study

Eric Soller, Grant Hoffman, Jill Riley, Tonya Dickson, Pamela Rogers, Larry Solomon, Keith March, Karen McNally-Heintzelman

Proceedings Volume 4609, (2002) https://doi.org/10.1117/12.432088

KEYWORDS: Adhesives, Arteries, Polymers, Surgery, Laser tissue interaction, In vivo imaging, Semiconductor lasers, Visualization, Proteins, Laser welding

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Showing 5 of 7 publications

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