Prof. Fiona M. Lyng Profile

Prof. Fiona M. Lyng

at Technological Univ Dublin

SPIE Involvement:

Author

Publications (15)

Proceedings Article | 16 March 2023 Poster + Paper

Optimisation of Raman spectral processing for classification of radiotherapeutic toxicity

Isha Behl, Dinesh K. R. Medipally, Chris Talbot, Aidan Meade, Fiona Lyng

Proceedings Volume 12387, 123870I (2023) https://doi.org/10.1117/12.2647843

KEYWORDS: Glasses, Raman spectroscopy, Toxicity, Radiotherapy, Plasma, Biological samples, Prostate cancer, Cancer, Blood

Read Abstract +

Proceedings Article | 15 March 2023 Presentation + Paper

The clinical transferability of Raman micro-spectroscopic systems for cervical cytopathology

Rubina Shaikh, Sarah Loughlin, Alison Malkin, John O'Leary, Cara Martin, Fiona Lyng

Proceedings Volume 12392, 1239205 (2023) https://doi.org/10.1117/12.2648316

KEYWORDS: Raman spectroscopy, Cervical cancer, Cell biology, Cancer, Microscopes, Biological samples, Glasses, Semiconductor lasers

Read Abstract +

Proceedings Article | 6 March 2023 Presentation + Paper

Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy

Isha Behl, Genecy Calado, Stephen Flint, Sheila Galvin, Claire Healy, Hugh Byrne, Fiona Lyng

Proceedings Volume 12373, 1237305 (2023) https://doi.org/10.1117/12.2654997

KEYWORDS: Biopsy, Raman spectroscopy, Biological samples, Statistical modeling, Cancer, Biological research, Histopathology, Statistical analysis

Read Abstract +

Proceedings Article | 21 February 2020 Paper

Comparative study of oral dysplasia by conventional and surface enhanced Raman spectroscopy of whole saliva

Amuthachelvi Daniel, Genecy Calado, Isha Behl, Stephen Flint, Sheila Galvin, Claire Healy, Hugh Byrne, Fiona Lyng

Proceedings Volume 11236, 112360A (2020) https://doi.org/10.1117/12.2539545

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Statistical analysis, Cancer, Spectroscopy, Diagnostics, Gold, Aluminum, Nanoparticles

Read Abstract +

SPIE Journal Paper | 4 May 2018 Open Access

Improved removal of blood contamination from ThinPrep cervical cytology samples for Raman spectroscopic analysis

Damien Traynor, Shiyamala Duraipandian, Cara Martin, John O'Leary, Fiona Lyng

JBO, Vol. 23, Issue 05, 055001, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.5.055001

KEYWORDS: Blood, Raman spectroscopy, Cell biology, Contamination, Spectroscopy, Statistical analysis, Cervical cancer, Hydrogen, Diagnostics, Analytical research

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 30 October 2017 Open Access

Raman spectral signatures of cervical exfoliated cells from liquid-based cytology samples

Padraig Kearney, Damien Traynor, Franck Bonnier, Fiona Lyng, John O'Leary, Cara Martin

JBO, Vol. 22, Issue 10, 105008, (October 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.10.105008

KEYWORDS: Raman spectroscopy, Cell biology, Principal component analysis, Cervical cancer, Proteins, Infrared signatures, Statistical analysis, Tissues, Infrared spectroscopy, Glasses

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 19 June 2015 Paper

Raman spectroscopic analysis of oral squamous cell carcinoma and oral dysplasia in the high-wavenumber region

Luis Felipe C. Carvalho, Franck Bonnier, Kate O'Callaghan, Jeff O'Sullivan, Stephen Flint, Lazaro P. Neto, Cláudio A. Soto, Laurita dos Santos, Airton Martin, Hugh Byrne, Fiona Lyng

Proceedings Volume 9531, 953125 (2015) https://doi.org/10.1117/12.2180996

KEYWORDS: Raman spectroscopy, Proteins, Tissues, Cancer, Tissue optics, Spectroscopy, Biopsy, Biological research, Statistical analysis, Biomedical optics

Read Abstract +

SPIE Journal Paper | 2 November 2012 Open Access

Raman spectroscopic analysis of human skin tissue sections ex-vivo: evaluation of the effects of tissue processing and dewaxing

Syed Ali, Franck Bonnier, Ali Tfayli, Helen Lambkin, Kathleen Flynn, Vincent McDonagh, Claragh Healy, T. Clive Lee, Fiona Lyng, Hugh Byrne

JBO, Vol. 18, Issue 06, 061202, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.061202

KEYWORDS: Raman spectroscopy, Skin, Tissues, Tissue optics, Biological research, Spectroscopy, Proteins, Collagen, Statistical analysis, Biomedical optics

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 9 June 2011 Paper

Collagen matrices as an improved model for in vitro study of live cells using Raman microspectroscopy

F. Bonnier, P. Knief, A. Meade, J. Dorney, K. Bhattacharya, F. Lyng, H. Byrne

Proceedings Volume 8087, 80870F (2011) https://doi.org/10.1117/12.889872

KEYWORDS: Raman spectroscopy, Collagen, In vitro testing, Confocal microscopy, Spectroscopy, Matrices, Imaging spectroscopy, 3D modeling, Molecular spectroscopy, Data modeling

Read Abstract +

Due to its high lateral resolution, Raman microspectrsocopy is rapidly becoming an accepted technique for the subcellular imaging of single cells. Although the potential of the technique has frequently been demonstrated, many improvements have still to be realised to enhance the relevancy of the data collected. Although often employed, chemical fixation of cells can cause modifications to the molecular composition and therefore influence the observations made. However, the weak contribution of water to Raman spectra offers the potential to study live cells cultured in vitro using an immersion lens, giving the possibility to record highly specific spectra from cells in their original state. Unfortunately, in common 2-D culture models, the contribution of the substrates to the spectra recorded requires significant data pre-processing causing difficulties in developing automated methods for the correction of the spectra. Moreover, the 2-D in vitro cell model is not ideal and dissimilarities between different optical substrates within in vitro cell cultures results in morphological and functional changes to the cells. The interaction between the cells and their microenvironment is crucial to their behavior but also their response to different external agents such as radiation or anticancer drugs. In order to create an experimental model closer to the real conditions encountered by the cell in vivo, 3-D collagen gels have been evaluated as a substrate for the spectroscopic study of live cells. It is demonstrated that neither the medium used for cell culture nor the collagen gels themselves contribute to the spectra collected. Thus the background contributions are reduced to that of the water. Spectral measurements can be made in full cell culture medium, allowing prolonged measurement times. Optimizations made in the use of collagen gels for live cells analysis by Raman spectroscopy are encouraging and studying live cells within a collagenous microenvironment seems perfectly accessible.

Proceedings Article | 3 June 2005 Paper

Correlation of spectroscopic and biochemical assays post-ionising radiation exposure in human skin cell analogues

A. Meade, H. Byrne, F. Lyng

Proceedings Volume 5826, (2005) https://doi.org/10.1117/12.611450

KEYWORDS: Raman spectroscopy, Luminescence, Spectroscopy, Proteins, Skin, Mode conditioning cables, Ionizing radiation, Tissue optics, Tissues, Statistical analysis

Read Abstract +

Proceedings Article | 3 June 2005 Paper

The potential of vibrational spectroscopy in the early detection of cervical cancer: an exciting emerging field

Eoghan O Faolain, Mary Hunter, Joe Byrne, Peter Kelehan, Hugh Byrne, Fiona Lyng

Proceedings Volume 5826, (2005) https://doi.org/10.1117/12.603344

KEYWORDS: Raman spectroscopy, Tissues, Spectroscopy, FT-IR spectroscopy, Infrared spectroscopy, Cancer, Absorption, Connective tissue, Infrared radiation, Cervical cancer

Read Abstract +

Proceedings Article | 3 June 2005 Paper

Fluorescence concentration studies of HiPco SWNTs and semi-conjugated polymers

S. Keogh, T. Hedderman, E. Gregan, G. Farrell, P. Lynch, G. Chambers, F. Lyng, H. Byrne

Proceedings Volume 5826, (2005) https://doi.org/10.1117/12.605060

KEYWORDS: Polymers, Composites, Single walled carbon nanotubes, Luminescence, Carbon nanotubes, Fluorescence spectroscopy, Spectroscopy, Raman spectroscopy, Absorption, Molecules

Read Abstract +

Proceedings Article | 27 August 2003 Paper

Using fluoresence spectra to distinguish between microalgae species

Emilia Mihaylova, Fiona Lyng, Hugh Byrne

Proceedings Volume 4876, (2003) https://doi.org/10.1117/12.463997

KEYWORDS: Luminescence, Microscopes, Confocal microscopy, In vivo imaging, Fluorescence spectroscopy, Raman spectroscopy, Photosynthesis, Spectroscopy, Ocean optics, Chlorine

Read Abstract +

Proceedings Article | 27 August 2003 Paper

Raman spectroscopic analysis of ionization processes in biological systems

Jennifer Conroy, Eoghan Faolain, Carmel Mothersill, C. Seymour, Fiona Lyng, Hugh Byrne

Proceedings Volume 4876, (2003) https://doi.org/10.1117/12.463638

KEYWORDS: Raman spectroscopy, Spectroscopy, Molecules, Ionization, Biological research, Cancer, Radiation effects, Molecular spectroscopy, Tissues, Ionizing radiation

Read Abstract +

Proceedings Article | 27 August 2003 Paper

Potential of Raman spectroscopy for the molecular characterization of human tumors

Eoghan Faolain, Jennifer Conroy, Mary Hunter, Peter Kelehan, Helen Lambkin, Carmel Mothersill, Hugh Byrne, Fiona Lyng

Proceedings Volume 4876, (2003) https://doi.org/10.1117/12.463630

KEYWORDS: Raman spectroscopy, Tissues, Proteins, Molecules, Tissue optics, Molecular interactions, Molecular spectroscopy, Cervix, Spectroscopy, Cancer

Read Abstract +

Showing 5 of 15 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years