This work presents the design and implementation of an endoscopic probe for point-of-care diagnosis of bladder cancer, with an outer diameter of 4.5 mm that allows for in-vivo usage. This triple-modality device can deliver volumetric OCT images, optoacoustic tomograms, and single point Raman spectroscopy that target complementary biomarkers. The probe features a piezo-based fiber scanner, which delivers the illumination or excitation light for all modalities, with a maximum Field of View of 1.6 mm. The same path is used for light collection for OCT imaging. A separate fiber is used for detection of the Raman signals, while two additional fibers with microcavity tips sense the ultrasonic waves for optoacoustic tomography. A hyperchromatic micro-optical objective provides a working distance optimized for each modality. The probe housing is produced by selective laser-induced etching of fused silica.
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