Exploitation of advanced, PACS-centric image analysis and interpretation pipelines provides well-developed storage,
retrieval, and archival capabilities along with state-of-the-art data providence, visualization, and clinical collaboration
technologies. However, pursuit of integrated medical imaging analysis through a PACS environment can be limiting in
terms of the overhead required to validate, evaluate and integrate emerging research technologies. Herein, we address
this challenge through presentation of a high-throughput bundled resource imaging system (HUBRIS) as an extension to
the Philips Research Imaging Development Environment (PRIDE). HUBRIS enables PACS-connected medical imaging
equipment to invoke tools provided by the Java Imaging Science Toolkit (JIST) so that a medical imaging platform (e.g.,
a magnetic resonance imaging scanner) can pass images and parameters to a server, which communicates with a grid
computing facility to invoke the selected algorithms. Generated images are passed back to the server and subsequently to
the imaging platform from which the images can be sent to a PACS. JIST makes use of an open application program
interface layer so that research technologies can be implemented in any language capable of communicating through a
system shell environment (e.g., Matlab, Java, C/C++, Perl, LISP, etc.). As demonstrated in this proof-of-concept
approach, HUBRIS enables evaluation and analysis of emerging technologies within well-developed PACS systems with
minimal adaptation of research software, which simplifies evaluation of new technologies in clinical research and
provides a more convenient use of PACS technology by imaging scientists.
Internet addicted patients (IAPs) have widely been increased, as Internet games are becoming very popular in daily life. The purpose of this study was to investigate regional brain activation patterns associated with excessive use of Internet games in adolescents. Six normal controls (NCs) and eight IAPs who were classified as addiction group by adapted version of DSM-IV for pathologic gambling were participated. 18F-FDG PET studies were performed for all adolescents at their rest and activated condition after 20 minutes of each subject's favorite Internet game. To investigate quantitative metabolic differences in both groups, all possible combinations of group comparison were carried out using Statistical Parametric Mapping (SPM 99). Regional brain activation foci were identified on Talairach coordinate. SPM results showed increased metabolic activation in occipital lobes for both groups. Higher metabolisms were seen at resting condition in IAPs than that of in NCs. In comparison to both groups, IAPs showed different patterns of regional brain metabolic activation compared with that of NCs. It suggests that addictive use of Internet games may result in functional alteration of developing brain in adolescents.
Hee-Joung Kim, Haijo Jung, Jin-O Hong, Ha-Kyu Jeong, Eun-Kyung Kim, Kyu-Ho Lee, Je-Kyung Seong, Jong Ho Je, In Kim, Yeukuang Hwu, Wen-Li Tsai, Hyung-Sik Yoo
A new 5C1 beam line was recently built on Pohang Light Source (PLS) in Korea for possible medical applications. An imaging system on the beam line consisted of silicon wafer attenuators, tungsten slit, CdWO4 scintillator, CCD camera, and personal computer. Both spatial resolution test pattern and glass capillary filled with air bubbles were imaged to evaluate resolution and phase-contrast effects for synchrotron imaging system, respectively. Mammographic accreditation phantom, cancerous human breast specimens, and fish and nude mouse were also imaged. Both spatial resolution and image quality of the synchrotron imaging system were compared with those of conventional mammography system. The images of resolution test pattern showed a few tens of micrometer spatial resolution on synchrotron imaging system. The images of capillary filled with air bubbles revealed phase contrast effect. Mammographic accreditation phantom, human breast specimen, and animal images with synchrotron imaging system showed much higher resolution with great details of object and higher enhanced contrast compared to those with conventional mammography system. We successfully implemented and tested a micrometer resolution imaging system on PLS 5C1 beam line. Using a simple and inexpensive synchrotron imaging system on PLS 5C1 beam line, micrometer resolution images for resolution test pattern, mammographic accreditation phantom, human breast specimens, and live animals were acquired and visually evaluated.
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