Dr. Huang-Chiao Huang Profile

Dr. Huang-Chiao Huang

Associate Professor of Bioengineering at Univ of Maryland College Park

SPIE Involvement:

Conference Program Committee | Author

Area of Expertise:

Photodynamic therapy , Combination therapy , Fluorescence diagnostics , Nanomedicine , Photochemistry

Websites:

Company Website

Publications (21)

Proceedings Article | 19 June 2024 Presentation

Presentation

Improving cancer photoimmunotherapy: Integrating targeted nanotechnology, a clinical laser microendoscopy, and fluorescence-guided intervention

Huang-Chiao Huang, Barry Liang, Sumiao Pang, Robert Perttila, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahmana, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa

Proceedings Volume PC13009, PC1300909 (2024) https://doi.org/10.1117/12.3012419

KEYWORDS: Photoimmunotherapy, Nanotechnology, Cancer, Photonic integrated circuits, Ovarian cancer, Mouse models, Chemotherapy, Animal model studies, Windows, Tumors

Read Abstract +

Proceedings Article | 8 April 2024 Presentation

Presentation

Fluorescence-guided photoimmunotherapy for peritoneal carcinomatosis

Barry Liang, Sumiao Pang, Robert Perttila, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang

Proceedings Volume PC12823, PC128230D (2024) https://doi.org/10.1117/12.3011885

KEYWORDS: Photoimmunotherapy, Photonic integrated circuits, Mouse models, Chemotherapy, Tumors, Resistance, Resection, Photomedicine, Ovarian cancer, Nanotechnology

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Proceedings Article | 13 March 2024 Presentation

Presentation

Synergistic photodynamic therapy and ethanol ablation of locally advanced tumors in vivo

Chen-Hua Ma, Jeffrey Yang, John Quinlan, Kathryn McNaughton, Tessa Hauser, Jenna Mueller, Huang-Chiao Huang

Proceedings Volume PC12823, PC128230F (2024) https://doi.org/10.1117/12.3011919

KEYWORDS: Bioalcohols, Ablation, Photodynamic therapy, Tumors, Tissues, In vivo imaging, Therapeutics, Liver, Transplantation, Toxicity

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

Excipient-free pure drug photosensitizer nanoparticles for PDT, imaging, and chemotherapy of cancer

John Quinlan, Collin Inglut, Idrisa Rahman, Huang Chiao Huang

Proceedings Volume PC12359, PC1235904 (2023) https://doi.org/10.1117/12.2655723

KEYWORDS: Photodynamic therapy, Nanoparticles, Cancer, Tumors, Optical imaging, Molecules, Brain cancer

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

Fluorescence-guided, targeted photochemotherapy of peritoneal carcinomatosis

Barry Liang, Robert Perttilä, Sumiao Pang, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang

Proceedings Volume PC12359, PC123590A (2023) https://doi.org/10.1117/12.2657053

KEYWORDS: Tumors, Ovarian cancer, Oncology, Mouse models, Luminescence, Laser systems engineering, Laser development, LASIK, Cancer, Abdomen

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

Test method for evaluating the photocytotoxic potential of fluorescence imaging products

Shruti Vig, Brandon Gaitan, Lucas Frankle, Miriam Adwan, Yu Chen, Rosalie Elespuru, Joshua Pfefer, Huang-Chiao Huang

Proceedings Volume PC12359, PC1235908 (2023) https://doi.org/10.1117/12.2652255

KEYWORDS: Luminescence, Safety, Visualization, Tissues, Standards development, Skin, Molecules, In vitro testing

Read Abstract +

Proceedings Article | 14 March 2023 Presentation

Presentation

The role of fluid shear stress in regulating photoimmunotherapy efficacy and immunogenic cell death (Conference Presentation)

Aaron Sorrin, Keri Zhou, Katherine May, Cindy Liu, Barry Liang, Dana Roque, Huang Chiao Huang

Proceedings Volume 12380, 1238008 (2023) https://doi.org/10.1117/12.2654653

KEYWORDS: Photoimmunotherapy, Ovarian cancer, Cell death, Toxicity, Nanoengineering, Cancer, Tumor growth modeling, Photodynamic therapy, Oxygen, Modulation

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Proceedings Article | 24 May 2022 Presentation

Presentation

Clinically relevant pure porphyrin nanoparticles for photodynamic therapy and priming applications

Collin Inglut, Jillian Stable, Brandon Gaitan, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert Robey, Graeme Woodworth, Michael Gottesman, Huang-Chiao Huang

Proceedings Volume PC12146, PC1214606 (2022) https://doi.org/10.1117/12.2618159

KEYWORDS: Photodynamic therapy, Nanoparticles, Tumors, Plasma display panels, Cancer, Brain, Photomedicine, Luminescence, Animal model studies, Tumor growth modeling

Read Abstract +

Liposomes have revolutionized the field of photomedicine. Photodynamic therapy (PDT) using Visudyne®, a liposomal photosensitizer formulation, has helped many patients globally. Since the FDA approved Visudyne® in 2002, countless studies have examined strategies to further improve the therapeutic index of lipid-based photosensitizing nanoconstructs. While liposomes can improve the pharmacokinetics of hydrophobic photosensitizers, they could also modulate cellular uptake and singlet oxygen production. Furthermore, it is evident that there are other immunological and toxicological considerations for the design of liposomal drugs. Accordingly, there is now an emerging trend to engineer carrier-free nanodrugs. Here, we developed a pure-drug nanoparticle using the clinically used verteporfin photosensitizer (termed nanoVP) for photodynamic applications. We validated the effects of nanoVP in three contexts: 1) cytotoxic PDT, 2) subtherapeutic PDT, and 3) dark toxicity. Using a brain cancer murine model, we showed that light activation of nanoVP reduced tumor volume by up to 54% compared to liposomal VP. Fluorescence imaging revealed that nanoVP had a superior tumor-to-liver tissue ratio (~0.92) compared to liposomal VP (~0.4). We further studied nanoVP-mediated PDT at subtherapeutic doses to achieve photodynamic priming (PDP). PDP has been shown to enhance drug delivery, activate antitumor immunity, and sensitize tumors to chemotherapy. This approach is particularly relevant in the brain, where high doses of PDT can result in edema, neurotoxicity, and even animal death. Using a rat model, we demonstrated that nanoVP-assisted PDP improved blood-brain barrier permeability and accumulation of a model drug (Evans Blue dye) in rat brains by >5 fold. Minimal to no brain damage was observed. Lastly, under dark conditions, we validated that nanoVP significantly reduced viability while liposomal VP stimulated cancer cell growth. Results from this work demonstrate the utility of nanoVP for cancer treatment. The development of pure-drug photosensitizing nanoparticles for photodynamic applications could further revolutionize the field of photomedicine.

Proceedings Article | 7 March 2022 Presentation

Presentation

Rationally designed light-activatable nanocomplex for multi-tier cancer cell targeting and photochemotherapy

Barry Liang, Michael Pigula, Yan Baglo, Daniel Najafali, Tayyaba Hasan, Huang-Chiao Huang

Proceedings Volume PC11940, (2022) https://doi.org/10.1117/12.2609687

KEYWORDS: Cancer, Plasma, Oncology, Toxicity, Therapeutic agents, Signal generators, Proteins, Photodynamic therapy, Ovarian cancer, Optical imaging

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Proceedings Article | 7 March 2022 Presentation

Presentation

The use of bioconjugates of porphyrin to overcome ABC drug transporter-mediated drug resistance

Barry Liang, Suresh Ambudkar, Huang-Chiao Huang

Proceedings Volume PC11940, (2022) https://doi.org/10.1117/12.2609732

KEYWORDS: Resistance, Photodynamic therapy, Cancer, Proteins, Toxicity, Tissues, Photosensitizer targeting, Molecules, Modulation, Breast cancer

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Proceedings Article | 5 March 2021 Presentation

Presentation

Photodynamic therapy-based combination regimen with EP4 inhibitors attenuates metastatic behavior in ovarian cancer

Aaron Sorrin, Jocelyn Reader, Cindy Liu, Julia Cicalo, Danial Najafali, Dana Roque, Huang Chiao Huang

Proceedings Volume 11628, 1162805 (2021) https://doi.org/10.1117/12.2581786

KEYWORDS: Ovarian cancer, Photoimmunotherapy, Photodynamic therapy, Receptors, Cancer, Tumors, Toxicity, Modulation, In vitro testing, Clinical trials

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Quantifying the photochemical damage potential of fluorescence contrast agents: singlet oxygen production

Brandon Gaitan, Rosalie Elespuru, Ellen Oskoui, Mariam Adwan, Anqi He, Huang-Chiao Huang, Yu Chen, Joshua Pfefer

Proceedings Volume 11660, 116600A (2021) https://doi.org/10.1117/12.2579521

KEYWORDS: Oxygen, Luminescence, Safety, Molecules, Industrial chemicals, Visualization, Standards development, Optical imaging, Molecular imaging

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SPIE Journal Paper | 26 September 2020 Open Access

Open Access

Depth-resolved imaging of photosensitizer in the rodent brain using fluorescence laminar optical tomography

Brandon Gaitan, Collin Inglut, Yi Liu, Yu Chen, Huang-Chiao Huang

JBO, Vol. 25, Issue 09, 096007, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.096007

KEYWORDS: Brain, Tissues, Neuroimaging, Luminescence, Signal attenuation, Imaging systems, Optical tomography, Capillaries, 3D image processing, Optical coherence tomography

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Proceedings Article | 20 April 2020 Presentation

Presentation

Using fluorescence laminar optical tomography to measure the distribution photodynamic drug in the brain to optimize dosage and treatment time (Conference Presentation)

Brandon Gaitan, Collin Inglut, Yu Chen, Huang-Chiao Huang

Proceedings Volume 11219, 112190J (2020) https://doi.org/10.1117/12.2550498

KEYWORDS: Luminescence, Brain, Optical tomography, Optical testing, Plasma display panels, Tissue optics, Tumors, Brain cancer, Blood brain barrier, Oxygen

Read Abstract +

Proceedings Article | 14 August 2019 Presentation

Presentation

Photosensitizing biomolecules and nanocrystals for anti-glioma photodynamic therapy (Conference Presentation)

Collin Inglut, Yan Baglo, Barry Liang, Jill Stabile, Yahya Cheema, Graeme Woodworth, Huang-Chiao Huang

Proceedings Volume 11070, 110701M (2019) https://doi.org/10.1117/12.2525904

KEYWORDS: Nanocrystals, Photodynamic therapy, Biomedical optics, Polymers, Macromolecules, Crystals, Photosensitizer targeting

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Proceedings Article | 14 August 2019 Presentation

Presentation

Photodynamic priming and VDR activation modulate tumor-stroma interactions and permeability for durable control and enhanced treatment tolerability (Conference Presentation)

Michael Pigula, Sriram Anbil, Huang-Chiao Huang, Yan Baglo, Mans Broekgaarden, Diane Simeone, Gian Paolo Dotto, Tayyaba Hasan

Proceedings Volume 11070, 1107063 (2019) https://doi.org/10.1117/12.2526104

KEYWORDS: Tumors, Modulation, Plasma display panels, Cancer, Resistance, Receptors

Read Abstract +

Proceedings Article | 14 August 2019 Presentation

Presentation

Microenvironmental cues in 3D cancer models to inform targeted PDT combinations (Conference Presentation)

Shubhankar Nath, Huang-Chiao Huang, Michael Pigula, Christina Conrad, Amjad Khan, William Hanna, Sepideh Afsar, Walfre Franco, Giuliano Scarcelli, Utkan Demirci, Tayyaba Hasan, Imran Rizvi

Proceedings Volume 11070, 110705S (2019) https://doi.org/10.1117/12.2526078

KEYWORDS: 3D modeling, Photodynamic therapy, Tumors, 3D acquisition, Cancer, Tumor growth modeling, Resistance, Oncology, Toxicity, Therapeutics

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Proceedings Article | 14 March 2018 Presentation

Presentation

Photodynamic therapy-based combinations to overcome molecular, cellular and stromal resistance mechanisms in ovarian and pancreatic cancer (Conference Presentation)

Imran Rizvi, Shubhankar Nath, Girgis Obaid, Huang-Chiao Huang, Mans Broekgaarden, Anne-Laure Bulin, Sriram Anbil, Utkan Demirci, David Kessel, Tayyaba Hasan

Proceedings Volume 10476, 1047604 (2018) https://doi.org/10.1117/12.2290472

KEYWORDS: Photodynamic therapy, 3D modeling, Resistance, Tumor growth modeling, Pancreatic cancer, Cancer, Oncology, 3D acquisition, Ovarian cancer, Therapeutics

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Proceedings Article | 26 April 2016 Presentation

Presentation

Repurposing of tetracyclines to overcome resistance pathways associated with photochemotherapy in cancer (Conference Presentation)

Joyce Liu, Huang-Chiao Huang, Imran Rizvi, Tayyaba Hasan

Proceedings Volume 9694, 96940V (2016) https://doi.org/10.1117/12.2217949

KEYWORDS: Cancer, Resistance, Ovarian cancer, Oncology, Therapeutics, Oxygen, Modulation, In vitro testing, Mouse models, Photomedicine

Read Abstract +

Proceedings Article | 26 April 2016 Presentation

Presentation

Mechanistic exploration of a bi-directional PDT-based combination in pancreatic cancer (Conference Presentation)

Huang-Chiao Huang, Srivalleesha Mallidi, Joyce Liu, Chun-Te Chiang, Zhiming Mai, Ruth Goldschmidt, Imran Rizvi, Neema Ebrahim-Zadeh, Tayyaba Hasan

Proceedings Volume 9694, 96940W (2016) https://doi.org/10.1117/12.2217925

KEYWORDS: Photodynamic therapy, Pancreatic cancer, Tumors, Cancer, Oncology, Toxicity, Tumor growth modeling, Current controlled current source

Read Abstract +

Proceedings Article | 13 March 2013 Paper

Paper

Towards image-guided photodynamic therapy of Glioblastoma

Srivalleesha Mallidi, Huang-Chiao Huang, Joyce Liu, Zhiming Mai, Tayyaba Hasan

Proceedings Volume 8568, 85681C (2013) https://doi.org/10.1117/12.2010684

KEYWORDS: Tumors, Photodynamic therapy, Ultrasonography, Photoacoustic spectroscopy, Brain, Luminescence, Photoacoustic imaging, Tissue optics, Cancer, Oncology

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Showing 5 of 21 publications

Conference Committee Involvement (8)

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXIII

25 January 2025 | San Francisco, California, United States

Biophotonics and Immune Responses XIX

28 January 2024 | San Francisco, California, United States

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII

27 January 2024 | San Francisco, California, United States

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI

28 January 2023 | San Francisco, California, United States

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX

22 January 2022 | San Francisco, California, United States

Showing 5 of 8 Conference Committees

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