Dr. Jimmy L. Su Profile

Dr. Jimmy L. Su

Sr. Biomedical Engineer at InfraReDx Inc

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Publications (6)

Proceedings Article | 6 April 2016 Presentation + Paper

A method to compensate for the underestimation of collagen with polarized picrosirius red imaging in human artery atherosclerotic plaques

C. A. Greiner, S. Grainger, J. Su, S. Madden, J. Muller

Proceedings Volume 9711, 97111R (2016) https://doi.org/10.1117/12.2211388

KEYWORDS: Composites, Optical fibers, Optical alignment, Microscopes, Cardiology, Cardiovascular disorders, Tissues, Visualization

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Proceedings Article | 15 March 2016 Paper

Ability of combined Near-Infrared Spectroscopy-Intravascular Ultrasound (NIRS-IVUS) imaging to detect lipid core plaques and estimate cap thickness in human autopsy coronary arteries

S. Grainger, J. Su, C. Greiner, M. Saybolt, R. Wilensky, J. Raichlen, S. Madden, J. Muller

Proceedings Volume 9708, 97084V (2016) https://doi.org/10.1117/12.2209664

KEYWORDS: Near infrared spectroscopy, Arteries, Image segmentation, Spectroscopy, Imaging spectroscopy, Intravascular ultrasound, Heart, Infrared imaging, Blood, Calcium, Tissues, Image resolution, Optical coherence tomography

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Proceedings Article | 29 February 2016 Presentation + Paper

Evaluation of combined near-IR spectroscopic (NIRS)-IVUS imaging as a means to detect lipid-rich plaque burden in human coronary autopsy specimens

Jimmy Su, Stephanie Grainger, Cherry Greiner, Michael Hendricks, Meghan Goode, Matthew Saybolt, Robert Wilensky, Sean Madden, James Muller

Proceedings Volume 9689, 96892V (2016) https://doi.org/10.1117/12.2209701

KEYWORDS: Near infrared spectroscopy, Arteries, Intravascular ultrasound, Heart, Coronary catheterization, Medical image processing, Medical imaging modalities, Medical imaging applications, Imaging systems, Clinical trials

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Intracoronary near-infrared spectroscopy (NIRS) can identify lipid in the coronary arteries, but lacks depth resolution. A novel catheter is currently in clinical use that combines NIRS with intravascular ultrasound (IVUS), which provides depth-resolved structural information via the IVUS modality. A measure designated as lipid-rich plaque burden (LRPB) has been proposed as a means to interpret the combined acoustic and optical information of NIRS-IVUS. LRPB is defined as the area created by the intersection of the NIRS lipid-rich arc with the corresponding IVUS-measured plaque burden. We determined the correlation in human coronary autopsy specimens between LRPB, a measure of lipid presence and extent available via intravascular imaging in patients, and the area of lipid-rich plaque as determined by the gold-standard of histology. Fifteen artery segments from 8 human autopsy hearts were imaged with the NIRS-IVUS system (TVC Imaging System, Infraredx Inc., Burlington, MA). Arteries were imaged in a specialty fixture that assured accurate co-registration between imaging and histology. The arteries were then fixed and divided into 2 mm blocks for histological staining. Pathological contouring of lipid-rich areas was performed on the stained thin sections for 54 lipid-rich blocks. Computation of LRPB was performed on transverse NIRS-IVUS frames corresponding to the histologic sections. The quantified LRPB was frequently higher than the lipid-rich plaque area determined by histology, because the region denoted by the EEL and lumen within the NIRS lipid-rich arc is not entirely comprised of lipid. Overall, a moderate to strong correlation (R = 0.73) was found between LRPB determined by NIRS-IVUS imaging and the lipid-rich plaque area determined by histology. LRPB, which can be measured in patients with NIRS-IVUS imaging, corresponds to the amount of lipid-rich plaque in a coronary artery. LRPB should be evaluated in prospective clinical trials for its ability to identify vulnerable plaques.

Proceedings Article | 23 February 2011 Paper

Photoacoustic imaging to guide needle injections

Jimmy Su, Andrei Karpiouk, Yun-Sheng Chen, Stanislav Emelianov

Proceedings Volume 7899, 78993A (2011) https://doi.org/10.1117/12.875219

KEYWORDS: Tissues, Ultrasonography, Photoacoustic spectroscopy, Metals, Transducers, Photoacoustic imaging, Natural surfaces, Visualization, Acoustics, Absorption

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SPIE Journal Paper | 1 March 2010 Open Access

Photoacoustic imaging of clinical metal needles in tissue

Jimmy Su, Andrei Karpiouk, Bo Wang, Stanislav Emelianov

JBO, Vol. 15, Issue 02, 021309, (March 2010) https://doi.org/10.1117/12.10.1117/1.3368686

KEYWORDS: Metals, Tissues, Transducers, Tissue optics, Photoacoustic imaging, Visualization, Ultrasonography, Absorption, Image filtering, Comets

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Proceedings Article | 12 February 2009 Paper

Spectroscopic intravascular photoacoustic imaging of neovasculature: phantom studies

Jimmy Su, Bo Wang, Stanislav Emelianov

Proceedings Volume 7177, 717727 (2009) https://doi.org/10.1117/12.807499

KEYWORDS: Blood, Absorption, Photoacoustic spectroscopy, Photoacoustic imaging, Intravascular ultrasound, Ultrasonography, Signal detection, Imaging spectroscopy, Spectroscopy, Tissue optics

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