In OCTA, resolution of retinal capillaries is limited by physical numerical aperture of human eye and the subject’s ocular aberrations. Adaptive optics OCTA has been demonstrated in instruments with large numerical aperture, originally designed for the visualization of retinal cells. In this work, we propose a high-speed, spectral domain sensorless adaptive optics OCTA instrument with a 3-mm beam to image retinal capillaries of all three retinal plexuses simultaneously, with high axial and lateral resolution. A novel and fast hill climbing algorithm was applied on the amplitude of six low-order Zernike modes to minimize ocular aberrations based on maximizing en face merit functions of the layer of interest computed in real time.
Sensorless Adaptive Optics (SAO) allows easy integration of adaptive optics in retina imaging systems, however the iterative nature of the SAO optimization process requires long time to perform aberration correction and the inevitable subject motion during the optimization could compromise the AO correction. Here we present a multi-modal SAO retina imaging system that includes Optical Coherence Tomography (OCT), OCT-Angiography, confocal Scanning Laser Ophthalmoscopy (cSLO), and fluorescence detection. To mitigate the motion artifact and increase the SAO performance, we developed volumetric image tracking to extract merit function of SAO only within the region of interests.
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