Ms. Junzhen Song Profile

Junzhen Song

at Hainan Univ

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Proceedings Article | 12 March 2024 Poster + Paper

Pancreatic pathology severity correlates with Aβ42 deposits and tau pathology in spontaneous type 2 diabetes mellitus cynomolgus monkeys

Zeyang Li, Xinxin Huang, Shanshan Huang, Junzhen Song, Feng Yue

Proceedings Volume 12843, 128430B (2024) https://doi.org/10.1117/12.3005146

KEYWORDS: Pathology, Alzheimer disease, Antibodies, Plasma, Glucose, Animal model studies, Proteins, Dementia

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Type 2 diabetes mellitus (T2DM) is associated with Alzheimer’s disease (AD). Islet amyloid polypeptide (IAPP) in pancreases and amyloid-β (Aβ) and neurogenic fibril tangles (NFT) in brains are pathologic markers of T2DM and AD, respectively. However, the relationship between the severity of T2DM pancreatic pathology and intrapancreatic AD-like pathology, including Aβ42 deposits and tau pathology, is unclear. In this study, we observed the pancreatic pathology of spontaneous T2DM cynomolgus monkeys by histological methods and immunohistochemistry. The results show that the pancreatic islet morphology was irregularly shaped, and islet cell density and IAPP-positive area were decreased in T2DM cynomolgus monkeys. Meanwhile, the severity of T2DM pancreatic pathology was evaluated based on islet β-cell volume. As a result, the decrease in β-cell volume was accompanied by increased areas of Aβ42, tau immunopositivly staining. Immunofluorescence staining of the T2DM pancreas pathology showed co-localization of IAPP with Aβ and tau, respectively. Our findings suggest that the decrease in islet β-cell volume can respond to the severity of T2DM pancreatic pathology, facilitate the formation and aggregation of Aβ42 and tau in pancreases, and play a role in AD development.

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