This paper is a part of research to develop convenient method for continuous monitoring of arterial blood pressure by non-invasive and non-oscillometric way. A simple optical method, using self-mixing in a diode laser, is used for detection of skin surface vibrations near the artery. These vibrations, which can reveal the pulsate propagation of blood pressure waves along the vasculature, are used for pulse wave registration. The registration of the Pulse Wave Transit Time (PWTT) is based on computing the time delay in different regions of the human body using an ECG as a reference signal. In this study, the comparison of method of optical self-mixing with other methods as photoplethysmographic (PPG) and bioimpedance (BI) for PWTT is done. Also correlation of PWTT, obtained with different methods, with arterial blood pressure is calculated.
In our study, we used a group of volunteers (34 persons) who made the bicycle exercise test. The test consisted of cycling sessions of increasing workloads during which the HR changed from 60 to 180 beats per minute. In addition, a blood pressure (NIBP) was registered with standard sphygmomanometer once per minute during the test and all NIBP measurement values were synchronized to other signals to find exact time moments where the systolic blood pressure was detected (Korotkoff sounds starting point). Computer later interpolated the blood pressure signal in order to get individual value for every heart cycle. The other signals were measured continuously during all tests. At the end of every session, a recovery period was included until person's NIBP and heart rate (HR) normalized.
As a result of our study it turned out that time intervals that were calculated from plethysmographic (PPG) waveforms were in the best correlation with systolic blood pressure. The diastolic pressure does not correlate with any of the parameters representing PWTT. The pulse wave signals measured by laser and piezoelectric transducer are very similar and do not have any qualitative differences. Since the detection of pulse wave by piezoelectric transducer is less complicated than laser detection, the piezo transducer should be preferred in such cases, but advantage of optical method of measurement is absent of any mechanical influence to artery.
The blood flow velocity registration method using an optical coherent photo detection in a diode laser is presented. The dependence of signal on distance and non-conventional self- mixing interferences has bene discussed. Also, an experimental device with pigtail laser diode is developed. This device is able to measure blood flow velocity or velocity of liquid suspension containing particles with size of erythrocytes. During experiments the liquid suspension containing polymer micro spheres with spheres diameter 7.0 microns and density 1.05 g/cc was used instead of real blood. The basis of the registration is the self-mixing that occurs in diode laser cavity when the radiation scattered back by the particles into the laser interferes with the field inside it and causes a changes of a laser pump current. National Instruments software LabView for Windows is used for output signal digitalization and pre-processing purposes. There is good correlation between calculated and measured with proposed device values of different velocities. Described device as application of self-mixing method highlighted the significant advantages of simplicity, compactness, and robustness as well as the self-aligning and self-detecting abilities of such methods when compared with the use of conventional interferometric methods.
The arterial pulse profile registration method using an optical coherent photodetection in a diode laser is presented. An experimental device with pigtail laser diode has been developed. This device is able to detect pulsation profiles of major arteries with potentially useful information including pulse wave velocity and profile of pulse pressure. The basis of the registration is the self- mixing that occurs in the diode laser cavity when the radiation, scattered back by the skin into the laser, interferes with the field inside it and causes the changes of the laser pump current. These changes are being registered in two different ways simultaneously; with using a photodiode accommodated in the rear facet of the diode laser package and with a help of small resistance resistor from the chain of laser pump current. The delay of pulse wave in different regions of human body is measured relatively to ECG signal. Registered signals are sorted after digitalization and pre-processed using LabView for Windows environment.
A simple device for small particles detection is presented, consisting of a single-mode diode or gas laser with external cavity. The basis of the measurement is the selfmixing that occurs in the laser active medium when the radiation, scattered back by the moving particle into the laser resonator, interferes with the field inside it and causes changes of a pump current. Information about the number, velocity and size of particles can be derived by processing the current pulses. This compact device is capable of detecting a single microndiameter particle movement.
A simple device for small particles detection is presented, consisting of a single-mode diode or gas laser with external cavity. The basis of the measurement is the selfmixing that occurs in the laser active medium when the radiation, scattered back by the moving particle into the laser resonator, interferes with the field inside it and causes changes of a pump current. Information about the number, velocity and size of particles can be derived by processing the current pulses. This compact device is capable of detecting a single microndiameter particle movement.
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