Optical coherence tomography (OCT) shows potential as an intraoperative guidance tool. However, OCT images are difficult to interpret and real-time analysis methods are needed to promote its clinical use. This study investigates deep learning-based OCT image classification with application on thyroid diseases. To evaluate the impact of data pre-processing and model architecture on classification performance, 2D and 3D deep learning models were implemented and trained on OCT data from ex-vivo thyroid samples. For 2D classification, deeper models and the ones using information from different spatial resolution achieved highest performance. However, 3D models outperform the 2D counterparts in most classification tasks.
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