Interest in measuring peripheral refraction rapidly and accurately has been stimulated by increasing evidence that the
eye's peripheral refractive state can influence axial growth. In response to this, a new clinical instrument, the
EyeMapper, was developed which performs quasi real-time global (central and peripheral) refraction measurements of
the human eye. The EyeMapper is an aberrometer comprising a unique deflection system to permit an extremely rapid visual field scan.
Refraction measurements are taken from -50° to +50° in 10° steps within 0.45 seconds. Multiple pupil imaging paths
through the deflection system provide improved lateral and axial pupil alignment, and by rotating the instrument around
its main optical axis, global power maps of the eye can be generated.
Using a model eye with a pivoting and translating reflective surface to simulate the peripheral and central retina, the
EyeMapper was cross-validated against a conventional aberrometer (COAS-HD, Wavefront Sciences, USA) and an
autorefractor (Shin-Nippon NVision K5001, Japan). In addition, the right eyes of ten participants were measured across
the horizontal visual field and in one eye, refraction measurements were performed globally. Overall, the EyeMapper
showed good agreement and improved repeatability when compared to the other two instruments.
Presbyopia is an age related, gradual loss of accommodation, mainly due to changes in the crystalline lens. As part of research efforts to understand and cure this condition, ex vivo, cross-sectional optical coherence tomography images of crystalline lenses were obtained by using the Ex-Vivo Accommodation Simulator (EVAS II) instrument and analyzed to extract their physical and optical properties. Various filters and edge detection methods were applied to isolate the edge contour. An ellipse is fitted to the lens outline to obtain central reference point for transforming the pixel data into the analysis coordinate system. This allows for the fitting of a high order equation to obtain a mathematical description of the edge contour, which obeys constraints of continuity as well as zero to infinite surface slopes from apex to equator. Geometrical parameters of the lens were determined for the lens images captured at different accommodative states. Various curve fitting functions were developed to mathematically describe the anterior and posterior surfaces of the lens. Their differences were evaluated and their suitability for extracting optical performance of the lens was assessed. The robustness of these algorithms was tested by analyzing the same images repeated times.
Presbyopia is the age related, gradual loss of accommodation, mainly due to changes in the crystalline lens.
As part of research efforts to understand and cure this condition, ex vivo, cross-sectional OCT images of
crystalline lenses were obtained and analyzed to extract their physical and optical properties. The raw OCT
images are distorted, as the probing beam passing through media of different refractive indices and
refraction on curved surfaces. In a first step, various filters, edge detection and pattern matching methods
are applied to isolate the edge contour. An ellipse is fitted to the lens outline to obtain central reference
point for transforming the pixel data into the analysis coordinate system. This allows for the fitting of high
order equation to obtain a mathematical description of the edge contour, which obeys constraints of
continuity as well as zero to infinite surface slopes from apex to equator. Robustness of these algorithms
are tested by analyzing the images at various contrast levels. Gradient refractive index of the lens is
determined and the physical shape is reconstructed. In a further refinement, the refraction on the curved
anterior surface is compensated to obtain the actual shape of the posterior surface. Once the physical shape
is fully reconstructed, the optical properties are determined by fitting conic sections to both surfaces and
calculating the power profile across the lens. The relative contribution of each of these refinement steps is
investigated by comparing their influence on the effective power of the lens.
A new instrument has been developed and built to measure the spatially resolved optical power of intra-ocular and contact lenses. Currently available instruments are based on either Hartmann Shack or Moiré Fringe techniques, which both have inherent limitations in terms of measurement range, sensitivity and achievable lateral resolution. Our new method uses a narrow laser beam which is scanned paraxially across the surface of the lens. The angle of the deflected beam is determined by capturing the lateral laser spot position at two different axial locations by means of a beam-splitter and two position sensitive, optical detectors. From the matrix of deflection angles, the spherical and cylindrical power components as well as higher order aberrations can be extracted and displayed as spatially resolved power maps. While measurement speed is compromised due to the scanning operation, the achievable lateral resolution can be as high as 20μm and the power accuracy in the order of milli-diopters. Soft contact lenses and foldable IOLs can be placed in wet cells to maintain hydration and form stability. Sample measurements of contact and intra ocular lenses are presented.
We propose a novel theoretical design of gradient index (GRIN) multifocal contact lens (MFCL) to compensate presbyopia and make predictions regarding its performance on a schematic model eye and to compare its performance with conventional aspheric progressive MFCL.
Our aim was to fabricate a bench-top physical model eye that closely replicates anatomical and optical properties of the average human eye, and to calibrate and standardize this model to suit normal viewing conditions and subsequently utilize it to understand the optical performance of corrective lens designs; especially multifocal
soft contact lenses. Using available normative data on ocular biometrics and Zemax ray-tracing software as a tool,
we modeled 25, 45 and 55 year-old average adult human eyes with discrete accommodation levels and pupil sizes.
Specifications for the components were established following manufacturing tolerance analyses. The cornea was
lathed from an optical material with refractive index of 1.376 @ 589 nm and the crystalline lenses were made of
Boston RGP polymers with refractive indices of 1.423 (45 & 55yr) and 1.429 (25yr) @ 589 nm. These two materials
served to model the equivalent crystalline lens of the different age-groups. A camera, the acting retina, was hosted
on the motor-base having translatory and rotary functions to facilitate the simulation of different states of ametropia
and peripheral refraction respectively. We report on the implementation of the first prototype and present some
simulations of the optical performance of certain contact lenses with specific levels of ametropia, to demonstrate the potential use of such a physical model eye. On completion of development, calibration and standardization, optical quality assessment and performance predictions of different ophthalmic lenses can be studied in great detail. Optical performance with corrective lenses may be reliably simulated and predicted by customized combined computational and physical models giving insight into the merits and pitfalls of their designs
Cataract surgery usually involves the replacement of the natural crystalline lens with a rigid or foldable intraocular
lens to restore clear vision for the patient. While great efforts have been placed on optimising the shape
and optical characteristics of IOLs, little is know about the mechanical properties of these devices and how
they interact with the capsular bag once implanted. Mechanical properties measurements were performed on 8
of the most commonly implanted IOLs using a custom build micro tensometer. Measurement data will be
presented for the stiffness of the haptic elements, the buckling resistance of foldable IOLs, the dynamic
behaviour of the different lens materials and the axial compressibility. The biggest difference between the lens
types was found between one-piece and 3-piece lenses with respect to the flexibility of the haptic elements
Lid angles and aperture size are important factors for fitting and on-eye performance of contact lenses. In particular, toric and translating bifocal lenses rely on predictable interaction with the eyelid for successful positioning and orientation. Traditionally, lid assessment and fitting evaluation is performed under slit lamp observation. Observations are limited to primary gaze and nasal or temporal directions. Quantification of lid parameters and lens positioning is subjective and depended on the skill of the practitioner. No commercial instrument is available off the shelf, which would be suitable to measure objectively ocular parameters and/or contact lens positioning under different directions of gaze. This is the likely reason why only one study has been published in which ocular characteristics for different gaze angles were obtained [1]. However, only a limited number of parameters and gaze directions were investigated. Almost all contact lenses are designed for and assessed under primary gaze. Considering that patients constantly change their gaze while wearing contact lenses, the quantification of contact lens movement and changes in ocular parameters with eye movement can contribute substantially to the understanding of lens performance and thereby lead to improved lens designs. This is of particular importance for toric and translating bifocal lenses. Their complex optical and topographical design requires precise positioning, orientation and movement with changes in gaze direction in order to provide adequate vision. Baron [2] suggested that the lower eyelid is the most important factor for lens movement of translating bifocal lenses, but questions still remained on the complete dynamics of on eye behaviour. For toric contact lenses, the rotational orientation is more important than vertical translation to obtain optimum visual correction. Most toric lenses feature a prism ballast design. Blinking movements, mainly of the upper eyelid, interact with the wedge like shape and squeeze the thick part downwards. It has been observed that the upper eyelid does not move in a straight downward movement, but also twists slightly to close the temporal side first [3]. Precise quantification of this motion and how it affects the contact lens movement have not been reported. A new instrument was designed and constructed to provide objective measurements of ocular parameters.
The ex vivo accommodation simulator stretches crystalline lenses radially under controlled conditions, while monitoring the changes in zonular tension and lens diameter. A dual coaxial laser beam system was added for measuring changes in optical power as the lens is stretched. The EVAS instrument was fully characterized and calibrated. The results from 3 porcine eyes will be presented. Several crystalline lenses, similar in shape and size to porcine lenses, were cast molded in silicone gels of different stiffness. These lenses were evaluated using the EVAS instrument and custom made lens holding fixtures. With their well defined shape and material properties, results from these measurements will be useful for cross-validation of finite element models.
A new instrument was developed to simulate the accommodation of excised human and animal crystalline lenses. The sclera is attached to 8 radially arranged translation stages and dissected into 8 segments. Change in accommodation is simulated by pulling and releasing the scleral segments, varying the load on the zonules and the capsular bag. Each translation stage is equipped with a sensitive force transducer for simultaneous recording of load and displacement. Additionally, changes in optical power, lens diameter, lens thickness and lens shape can be observed and quantified while the lens is stretched and released. The sensitivity and accuracy of the instrument was verified using steel springs and elastic bands. Preliminary results from sensitivity testing and instrument calibration are presented.
The pre-corneal tear layer provides an important optical as well as physiological function. Hence, the ability to assess the quality and behavior of tears, especially in dry-eye, marginal dry-eye and contact lens patients is important. While a large range of clinical tests exists for assessing tear quality, many are subjective and show poor repeatability. Since the tear meniscus is dependent on factors such as volume, viscosity and 'wettability,' we attempted to develop an optical system for imaging the tear meniscus. A basic prototype to test feasibility has been constructed. An algorithm for computing the profile of the meniscus was also developed. The methodology is described together with some examples of tear menisci imaged and analyzed.
With the increasing complexity of contact lens designs and the demand on visual performance required by wearers, the ability to assess the design and optical quality of a contact lens is an important capability. While more complex systems such as Hartmann-Shack devices exist, practitioners often call for a simple, quick and inexpensive system that can provide the above functions. A simple optical system based on modifying the knife-edge test has been developed for assessing design and optical quality. Incorporation of a Badal-type lens layout added lens power measurement capability. This system provides the practitioner with the ability to undertake rapid visual assessment of a contact lens's quality.
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