Obstetric risks, associated with pre-eclampsia, such as maternal age and pre-existing conditions are on the rise, along with the risk of ectopic calcification and placental vascular dysfunction. We investigated Slc20a2 mice models through non-invasive commercialized and synergistic ultrasound and photoacoustic imaging, which provide dual-wavelength images and radio frequency data. The increased ectopic placental vascular calcification model exhibits reduced fetal growth and decreased postnatal bone mineral density. Our experiments established a significant difference in both placental function and structural differences between normal and diseased placentas through the provided oxygen saturation and quantitative ultrasound spectral parameters.
As medical advances allow the maternal age to rise, the risk of ectopic calcification and placental vascular dysfunction increases, both associated with preeclampsia. We investigated Slc20a2 mice models through non-invasive commercial ultrasound and photoacoustic imaging. This model exhibits increased ectopic placental vascular calcification, reduced fetal growth, and decreased postnatal bone mineral density. Our experiments established a significant difference in both placental function and structural differences between normal and diseased placentas. Dual-wavelength images and radio frequency data provided oxygen saturation and quantitative ultrasound spectral parameters that proved the control placentas can be distinguished from knockout placentas.
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