In this study, we developed a prototype interstitial all-optical needle photoacoustic sensing probe for clinical translation of prostate cancer. The performance of the PA needle probe was examined on intact human prostates ex vivo to simulate the transrectal ultrasound (US) guided transperineal prostate biopsy procedures. Analysis based on PA spectrum analysis in 8-28 MHz range of acquired RF signals at multi-wavelengths shows statistical difference between benign and cancerous regions (n=49, p<0.05). Multivariate SVM analysis using linear and midbandfit parameters can obtain an accuracy close to 90%.
This study examined the performance of a clinical translatable needle photoacoustic sensing probe in intact prostates removed through prostatectomy procedures. Compared to the prototype probe in our previous studies, the latest version probe possesses fiber optic hydrophone with a dome-shaped tip that provides better sensitivity and sampling volume. The optical components were integrated into a customized clinical standard steel needle with a side opening and protected by medical grade polyurethane. The needle probe was examined in a setup mimicking a transrectal ultrasound guided transperineal prostate biopsy procedure. Preliminary tests showed promising results in differentiating between benign and aggressive cancer tissues in prostate.
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