Cell-based assays for environmental monitoring enable quick information about a broad spectrum of possible
contaminations. A key parameter that conveys information about the state of the cell culture is its electrical
impedance, representing the amount of cell adhesion and morphological changes. We present a novel sensor for
cell impedance measurements designed for application in a multi-parameter cell chip based on CMOS technology.
A primary goal in the development of the sensor was keeping its interface to the external world as simple and
robust as possible. This was achieved by integrating the sensor front-end electronics in close physical proximity
to the sensing site. The result is a CMOS impedance-to-frequency converter with digital square wave output. A
test chip featuring an array of 64 sensing microelectrodes, each addressable by a digital interface, was fabricated
in a standard CMOS technology supplemented with a backend process for planar gold electrodes. We present
measurement results with cells that demonstrate the successful operation of the system and its ability to capture
changes in the cells' impedance caused by the model toxin cytochalasin.
Conference Committee Involvement (1)
Lab-on-a-Chip: Platforms, Devices, and Applications
26 October 2004 | Philadelphia, Pennsylvania, United States
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.