Dr. Michele Lacerenza Profile

Dr. Michele Lacerenza

PhD Student

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Publications (18)

SPIE Journal Paper | 15 November 2024 Open Access

Cerebral baseline optical and hemodynamic properties in pediatric population: a large cohort time-domain near-infrared spectroscopy study

Valeria Calcaterra, Michele Lacerenza, Caterina Amendola, Mauro Buttafava, Davide Contini, Virginia Rossi, Lorenzo Spinelli, Sara Zanelli, Gianvincenzo Zuccotti, Alessandro Torricelli

NPh, Vol. 11, Issue 04, 045009, (November 2024) https://doi.org/10.1117/12.10.1117/1.NPh.11.4.045009

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SignificanceReference cerebral near-infrared spectroscopy (NIRS) data on the pediatric population are scarce, and in most cases, only cerebral oxygen saturation (SO2) measured by continuous wave spatially resolved spectroscopy NIRS is reported. Absolute data for baseline optical and hemodynamic parameters are missing.AimWe aimed at collecting baseline cerebral optical parameters [absorption coefficient, μa; reduced scattering coefficient, μs′; differential pathlength factor (DPF)] and hemodynamic parameters [oxy-hemoglobin content (HbO2), deoxyhemoglobin content (HHb), total hemoglobin content (tHB), SO2] in a large cohort of pediatric patients. The objectives are to establish reference optical values in this population and evaluate the reproducibility of a commercial time domain (TD) NIRS tissue oximeter.ApproachTD NIRS measurements were performed in the prefrontal cortex at 686 and 830 nm with a 2.5-cm source–detector distance and 1-Hz acquisition rate. Five independent measurements (after probe replacement) were taken for every subject. TD NIRS data were fitted to a photon diffusion model to estimate the optical parameters. From the absorption coefficients, the hemodynamic parameters were derived by Beer’s law. Auxological and physiological information was also collected to explore the potential correlations with NIRS data.ResultsWe measured 305 patients in the age range of 2 to 18 years. Absolute values for baseline optical and hemodynamic parameters were shown as a function of age and auxological variables. From the analysis of the repositioning after probe replacement, the time-domain near-infrared spectroscopy device exhibited an average precision (intended as coefficient of variation) of <5% for μs′, DPF, HbO2, HHb, and tHb, whereas precision was <2% for SO2.ConclusionsWe provided baseline values for optical and hemodynamic parameters in a large cohort of healthy pediatric subjects with good precision, providing a foundation for future investigations into clinically relevant deviations in these parameters.

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Proceedings Article | 9 August 2023 Paper

Non-invasive monitoring of canine tissue hemodynamics undergoing a hyperbaric chamber treatment (HBO2) by time domain near infrared spectroscopy

Lorenzo Frabasile, Michele Lacerenza, Davide Contini, Mauro Buttafava, Annalisa Ferri, Michela Minero, Emanuela Dalla Costa, Alessandro Torricelli

Proceedings Volume 12628, 1262806 (2023) https://doi.org/10.1117/12.2670548

KEYWORDS: Tissues, Vacuum chambers, Near infrared spectroscopy, Oxygenation, Oxygen, Hemodynamics, Head, Animals, Tissue optics, Skin

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SPIE Journal Paper | 15 June 2022 Open Access

Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise

Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Michał Kacprzak, Piotr Sawosz, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu-Venkata-Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Lorenzo Frabasile, Pietro Levoni, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Paola Taroni, Alberto Tosi, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

JBO, Vol. 27, Issue 07, 074716, (June 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.074716

KEYWORDS: Raster graphics, Optical properties, Diffuse optical imaging, Scattering, Imaging spectroscopy, Absorption, Tissue optics, Spectroscopes, Sensors, Oximetry

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Proceedings Article | 7 March 2022 Presentation

VASCOVID: a smart platform combining near-infrared time-domain and diffuse correlation spectroscopies for management of severe COVID-19 patients

Marta Zanoletti, Caterina Amendola, Mauro Buttafava, Talyta Carteano, Lorenzo Cortese, Davide Contini, Luc Demarteau, Lorenzo Frabasile, Claudia Guadagno, Tijl Houtbeckers, Umut Karadeniz, Michele Lacerenza, Jaume Mesquida, Shahrzad Parsa, Eduardo Garrido Sagarzazu, Sanathana Konugolu Venkata Sekar, Jakub Tomanik, Alessandro Torricelli, Alberto Tosi, Udo Weigel, Tessa Wagenaar, Muhammad Atif Yaqub, Turgut Durduran

Proceedings Volume PC11951, PC119510D (2022) https://doi.org/10.1117/12.2609530

KEYWORDS: Near infrared spectroscopy, Spectroscopy, Therapeutics, Oxygen, Oximeters, Mode conditioning cables, Lung, Injuries, Diffuse optical imaging, Artificial intelligence

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Proceedings Article | 3 March 2022 Paper

Breaking the rules of time-domain diffuse optics: working with 1 cm2 SiPM and well-beyond the single-photon statistics

L. Di Sieno, E. Avanzi, F. Acerbi, A. Gola, M. Lacerenza, A. Behera, D. Contini, A. Dalla Mora

Proceedings Volume 11974, 119740A (2022) https://doi.org/10.1117/12.2608656

KEYWORDS: Photons, Sensors, Absorption, Microchannel plates, Scattering, Diffuse optical imaging, Chromium, Single photon detectors, Light harvesting, Solids

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Showing 5 of 18 publications

Conference Committee Involvement (1)

Clinical and Translational Neurophotonics 2025

25 January 2025 | San Francisco, California, United States

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