Ms. Natsumi Shimazaki Profile

Natsumi Shimazaki

at Keio Univ

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Author

Publications (14)

Proceedings Article | 14 February 2018 Presentation + Paper

Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo

M. Kobayashi, K. Suganuma, N. Shimazaki, E. Ogawa, T. Arai

Proceedings Volume 10471, 104710R (2018) https://doi.org/10.1117/12.2289329

KEYWORDS: Arteries, Rhodamine B, Luminescence, Laser development, Injuries, Blood circulation, Microscopes, Laser applications, Clinical trials, Applied physics

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Proceedings Article | 15 February 2017 Paper

Laser driven short-term thermal angioplasty: enhancement of drug delivery performance by heating with tension

Kao Suganuma, Rie Homma, Natsumi Shimazaki, Emiyu Ogawa, Tsunenori Arai

Proceedings Volume 10062, 100620J (2017) https://doi.org/10.1117/12.2250757

KEYWORDS: Laser therapeutics, Injuries, Arteries, Rhodamine B, Luminescence, Collagen, Photothermal interactions, Blood vessels, Laser applications, Clinical trials, Blood circulation

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Proceedings Article | 31 October 2016 Paper

The novel drug delivery to vascular wall using laser driven thermal balloon: basic study ex vivo

Kao Suganuma, Rie Homma, Natsumi Shimazaki, Emiyu Ogawa, Tsunenori Arai

Proceedings Volume 10024, 100242M (2016) https://doi.org/10.1117/12.2245828

KEYWORDS: Laser therapeutics, Arteries, Rhodamine B, Luminescence, Collagen, Metals, Injuries, Chemical oxygen iodine lasers, Laser irradiation, Laser applications

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Proceedings Article | 7 March 2016 Paper

Heating drug delivery to vascular wall with Rhodamine B and fluorescence labeled Paclitaxel ranging 50 to 70°C: ex vivo study

R. Homma, M. Shinozuka, N. Shimazaki, T. Arai

Proceedings Volume 9706, 97060G (2016) https://doi.org/10.1117/12.2210780

KEYWORDS: Rhodamine B, Luminescence, Ranging, Arteries, Microscopes, CCD cameras, Scanning electron microscopy, Electron microscopes, Collagen, Photothermal interactions, Image analysis, Fluorescence spectroscopy, Injuries

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Proceedings Article | 26 February 2014 Paper

Acute cell death rate of vascular smooth muscle cells during or after short heating up to 20s ranging 50 to 60°C as a basic study of thermal angioplasty

Machiko Shinozuka, Natsumi Shimazaki, Emiyu Ogawa, Naoki Machida, Tsunenori Arai

Proceedings Volume 8941, 89410L (2014) https://doi.org/10.1117/12.2039040

KEYWORDS: Cell death, Arteries, In vitro testing, In vivo imaging, Ranging, Injuries, Microscopes, Temperature metrology, Thermal effects, Biomedical optics

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Proceedings Article | 8 March 2013 Paper

Laser-driven short-duration heating angioplasty: dilatation performance in cadaver atherosclerotic femoral arteries

Natsumi Shimazaki, Sho Naruse, Tsunenori Arai, Nobuaki Imanishi, Sadakazu Aiso

Proceedings Volume 8565, 85654E (2013) https://doi.org/10.1117/12.2005432

KEYWORDS: Arteries, Intravascular ultrasound, Tissues, Temperature metrology, Collagen, Prototyping, Laser therapeutics, Laser irradiation, Injuries, Luminescence

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Proceedings Article | 9 February 2012 Paper

Laser-driven short-duration heating angioplasty: chronic artery lumen patency and histology in porcine iliac artery

Natsumi Shimazaki, Mie Kunio, Sho Naruse, Tsunenori Arai, Masami Sakurada

Proceedings Volume 8207, 82074F (2012) https://doi.org/10.1117/12.909870

KEYWORDS: Arteries, Injuries, Prototyping, Angiography, Microscopes, Laser therapeutics, Patents, Luminescence, Laser irradiation, Image segmentation

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Proceedings Article | 9 February 2012 Paper

Influences on vascular wall smooth muscle cells with novel short-duration thermal angioplasty

M. Kunio, N. Shimazaki, T. Arai, M. Sakurada

Proceedings Volume 8207, 82074D (2012) https://doi.org/10.1117/12.906066

KEYWORDS: In vivo imaging, Arteries, Injuries, Angiography, Prototyping, Temperature metrology, Image analysis, Laser therapeutics, Tissues, Francium

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Proceedings Article | 18 February 2011 Paper

Basic study of effects on the smooth muscle cells' proliferation with novel short-term thermal angioplasty in vitro and in vivo

M. Kunio, N. Shimazaki, A. Ito, T. Hayashi, T. Arai, M. Sakurada

Proceedings Volume 7883, 78833L (2011) https://doi.org/10.1117/12.873791

KEYWORDS: In vivo imaging, Arteries, In vitro testing, Receptors, Injuries, X-ray imaging, X-rays, Collagen, Microscopes, Francium

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Proceedings Article | 12 February 2010 Paper

Collagen thermal denaturation study for thermal angioplasty based on modified kinetic model: relation between the artery mechanical properties and collagen denaturation rate

N. Shimazaki, T. Hayashi, M. Kunio, T. Arai

Proceedings Volume 7562, 75620X (2010) https://doi.org/10.1117/12.841653

KEYWORDS: Arteries, Collagen, Thermal modeling, Scattering, Birefringence, Proteins, Temperature metrology, Light scattering, Optical testing, Laser development

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We have been developing the novel short-term heating angioplasty in which sufficient artery lumen-dilatation was attained with thermal softening of collagen fiber in artery wall. In the present study, we investigated on the relation between the mechanical properties of heated artery and thermal denaturation fractures of arterial collagen in ex vivo. We employed Lumry-Eyring model to estimate temperature- and time-dependent thermal denaturation fractures of arterial collagen fiber during heating. We made a kinetic model of arterial collagen thermal denaturation by adjustment of K and k in this model, those were the equilibrium constant of reversible denaturation and the rate constant of irreversible denaturation. Meanwhile we demonstrated that the change of reduced scattering coefficient of whole artery wall during heating reflected the reversible denaturation of the collagen in artery wall. Based on this phenomenon, the K was determined experimentally by backscattered light intensity measurement (at 633nm) of extracted porcine carotid artery during temperature elevation and descending (25°C→80°C→25°C). We employed the value of according to our earlier report in which the time-and temperature- dependent irreversible denaturation amount of the artery collagen fiber that was assessed by the artery birefringence. Then, the time- and temperature- dependent reversible (irreversible) denaturation fraction defined as the reversible ((irreversible) denatured collagen amount) / (total collagen amount) was calculated by the model. Thermo-mechanical analysis of artery wall was performed to compare the arterial mechanical behaviors (softening, shrinkage) during heating with the calculated denaturation fraction with the model. In any artery temperature condition in 70-80°, the irreversible denaturation fraction at which the artery thermal shrinkage started was estimated to be around 20%. On the other hand, the calculated irreversible denaturation fraction remained below 5% and reversible denaturation fraction reached up to 20% while the artery softening occurred without shrinkage. We think that our model of arterial collagen thermal denaturation might be reasonable to estimate the artery mechanical properties during heating.

Proceedings Article | 12 February 2009 Paper

Development of novel short-term heating angioplasty: thermal denaturation dynamics of collagen in artery wall

N. Shimazaki, H. Tokunaga, Y. Katou, T. Hayashi, T. Arai

Proceedings Volume 7175, 71750R (2009) https://doi.org/10.1117/12.808498

KEYWORDS: Arteries, Collagen, Light scattering, Temperature metrology, Scattering, Metals, Fluid dynamics, Injuries, Absorption, Hydrogen

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We have studied to develop the new thermal angioplasty methodology, photo-thermo dynamic balloon angioplasty (PTDBA), which provides artery dilatation with short-term (<15s) and uniform heating through the balloon by the combination of the efficient laser driven heat generation and fluid perfusion. Thermal denaturation degree of the collagen in artery media may be the important factor to attain sufficient artery dilatation for the PTDBA. In order to predict the optimum heating condition i.e. the balloon temperature and heating duration, we investigated the thermal denaturation dynamics of artery collagen in ex vivo. The extracted fresh porcine carotid artery was used. The temperature-dependent light scattering property and mechanical property of the artery specimen were simultaneously measured during artery temperature rising by specially made setup to assess the denaturation of arterial collagen. The change rate of the backscattered light intensity from the artery specimen; I(T)/I₀ with 633nm was measured to evaluate the artery scattering property change with the thermal denaturation. The artery specimen was heated from 25°C to 80°C with constant temperature rising rate of 3°C/min. The measured I(T)/I₀ was suddenly increased over 48°C. This boundary temperature might be the initiation temperature of the arterial collagen denaturation. We defined the variation of the I(T)/I₀ as the collagen denaturation ratio, and calculated the reactive enthalpy by the chemical equilibrium theory. Since the calculated enthalpy was similar to the enthalpy in literature report, the variety of I(T)/I₀ during the temperature rising might be attributed to the collagen conformational change due to the denaturation. In terms of the artery internal force measurement, the artery force was decreased with increasing of the artery temperature up to 65°C (i.e. softening), and increased over 65°C (i.e. shrinkage). We confirmed that the changes of the backscattered light (at 633nm in wavelength) from the artery might represent the artery collagen thermal denaturation degree.

Proceedings Article | 23 March 2007 Paper

Ho:YAG laser irradiation in blood vessel as a vasodilator: ex-vivo study

E. Nakatani, T. Iwasaki, K. Kaneko, N. Shimazaki, T. Arai

Proceedings Volume 6424, 642420 (2007) https://doi.org/10.1117/12.700045

KEYWORDS: Laser irradiation, Arteries, Laser energy, Laser therapeutics, Collagen, Birefringence, Blood vessels, Pulsed laser operation, Photography, In vivo imaging

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We studied Ho:YAG laser irradiation in blood vessel as a vasodilator ex vivo. We thought that the Ho:YAG laser-induced bubble expansion might be able to dilate the vessel because we found the vessel wall expansion after the Ho:YAG laser irradiation, that is steady deformation, in the vessel ex vivo. There have been many reports regarding to the Ho:YAG laser irradiation in the vessel. Most of studies concentrated on the interaction between Ho:YAG laser irradiation and vessel wall to investigate side effect on Ho:YAG laser angioplasty. We proposed to use the Ho:YAG laser-induced bubble expansion as a vasodilator. We studied vasodilation effect of the Ho:YAG laser-induced bubble ex vivo. The flash lamp excited Ho:YAG laser surgical unit (IH102, NIIC, Japan) (&lgr;=2.1&mgr;m) was used. The laser energy was delivered by a silica glass fiber (outer diameter: 1000&mgr;m, core diameter: 600&mgr;m). The laser-induced bubble was generated in the extracted fresh porcine carotid artery with the warmed saline perfusion. The laser energy at the fiber tip was ranging from 170-1300mJ per pulse. Number of the laser irradiation was ranged from 20pulses to 100pulses. The outer diameter of the vessel was observed. To examine the change in mechanical properties of the vessel wall, the stress-strain curve of the laser-irradiated vessel was measured. Birefringence observation and microscopic observation of staining specimen were performed. When the laser energy was set to 1300mJ per pulse, the outer diameter of the vessel after the laser irradiation was expanded by 1.4 times comparing with that of before the laser irradiation and the dilatation effect was kept even at 10minutes after the irradiation. The elasticity modulus of the artery by collagen was changed by the laser irradiation. In the polarized microscopic observation, the brightness of the intimal side of the vessel is increased comparing with that of the normal. We think this brightness increasing may be attributed to birefringence change by the arrangement of stretched collagen fiber. We suppose it is likely to be able to use the Ho:YAG laser irradiation as a temporary vasodilater tool in spite of further study should be performed.

Proceedings Article | 23 March 2007 Paper

Development of novel short-term heating angioplasty: diameter and elasticity change of vascular wall ex vivo

Natsumi Shimazaki, Kenji Kaneko, Eriko Nakatani, Tsunenori Arai

Proceedings Volume 6424, 642424 (2007) https://doi.org/10.1117/12.701797

KEYWORDS: Collagen, Arteries, Injuries, Prototyping, Temperature metrology, Safety, Nd:YAG lasers, Diagnostics, Metals, Laser irradiation

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Proceedings Article | 6 February 2007 Paper

Utility of birefringence changes due to collagen thermal denaturation rate process analysis: vessel wall temperature estimation for new short term heating balloon angioplasty

Kenji Kaneko, Natsumi Shimazaki, Maya Gotoh, Eriko Nakatani, Tsunenori Arai

Proceedings Volume 6435, 64350F (2007) https://doi.org/10.1117/12.699962

KEYWORDS: Birefringence, Collagen, Tissues, Scanning electron microscopy, Temperature metrology, Tissue optics, Microscopy, In vivo imaging, Arteries, Microscopes

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Showing 5 of 14 publications

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