Dr. Patrick J. Codd Profile

Dr. Patrick J. Codd

at Duke Univ Medical Ctr

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Author

Publications (6)

Proceedings Article | 4 March 2022 Presentation + Paper

Creation of noncontact device for use in brain metastasis margin identification in ex vivo mouse brain

Matthew Tucker, Matthew Lacayo, Suzanna Joseph, Weston Ross, Pakawat Chongsathidkiet, Peter Fecci, Patrick Codd

Proceedings Volume 11945, 1194507 (2022) https://doi.org/10.1117/12.2608975

KEYWORDS: Tumors, Luminescence, Brain, Tissues, Surgery, Melanoma, Laser tissue interaction, Cancer, Laser induced fluorescence, Fluorescence spectroscopy

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Because contemporary intraoperative tumor detection modalities, such as intraoperative MRI, are not ubiquitously available and can disrupt surgical workflow, there is an imperative for an accessible diagnostic device that can meet the surgeon’s needs in identifying tissue types. The objective of this paper is to determine the efficacy of a novel non-contact tumor detection device for metastatic melanoma boundary identification in a tissue-mimicking phantom, evaluate the identification of metastatic melanoma boundaries in ex vivo mouse brain tissue, and find the error associated with identifying this boundary. To validate the spatial and fluorescence resolution of the device, tissue-mimicking phantoms were created with modifiable optical properties. Phantom tissue provided ground truth measurements for fluorophore concentration differences with respect to spatial dimensions. Modeling metastatic disease, ex vivo melanoma brain metastases were evaluated to detect differences in fluorescence between healthy and neoplastic tissue. This analysis includes determining required-to-observe fluorescence differences in tissue. H&E staining confirmed tumor presence in mouse tissue samples. The device detected a difference in normalized average fluorescence intensity in all three phantoms. There were differences in fluorescence with the presence and absence of melanin. The estimated tumor boundary of all tissue phantoms was within 0.30 mm of the ground truth tumor boundary for all boundaries. Likewise, when applied to the melanoma-bearing brains from ex vivo mice, a difference in normalized fluorescence intensity was successfully detected. The potential prediction window for the tumor boundary location is less than 1.5 mm for all ex vivo mouse brain tumors boundaries. We present a non-contact, laser-induced fluorescence device that can identify tumor boundaries based on changes in laser-induced fluorescence emission intensity. The device can identify phantom ground truth tumor boundaries within 0.30 mm using instantaneous rate of change of normalized fluorescence emission intensity and can detect endogenous fluorescence differences in melanoma brain metastases in ex vivo mouse tissue.

Proceedings Article | 21 February 2020 Presentation + Paper

Model for and analysis of intraoperative brain tumor boundary detection based on known spectral signatures of glioblastoma

Weston Ross, Matthew Tucker, Guangshen Ma, Patrick Codd

Proceedings Volume 11229, 1122918 (2020) https://doi.org/10.1117/12.2546329

KEYWORDS: Tumors, Tissues, Laser tissue interaction, Surgery, Brain, Luminescence

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Proceedings Article | 20 February 2020 Presentation + Paper

Characterization of photoablation versus incidence angle in soft tissue laser surgery: an experimental phantom study

Guangshen Ma, Weston Ross, Matthew Tucker, Patrick Codd

Proceedings Volume 11238, 112380G (2020) https://doi.org/10.1117/12.2546229

KEYWORDS: Laser ablation, Laser tissue interaction, Natural surfaces, Laser therapeutics, Optical simulations, Error analysis, Pulsed laser operation, Laser vision correction, Gas lasers, Laser cutting

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Proceedings Article | 17 February 2020 Presentation + Paper

Creation of a non-contact, automated brain tumor detection device for use in brain tumor resection

Matthew Tucker, Suzanna Joseph, Weston Ross, Guangshen Ma, Pakawat Chongsathidkiet, Peter Fecci, Patrick Codd

Proceedings Volume 11225, 112250C (2020) https://doi.org/10.1117/12.2546603

KEYWORDS: Tumors, Brain, Tissues, Melanoma, Luminescence, Laser tissue interaction, Cancer, Surgery, Molecules, Spectroscopy

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Proceedings Article | 8 February 2018 Paper

Optimized path planning for soft tissue resection via laser vaporization

Weston Ross, Neil Cornwell, Matthew Tucker, Brian Mann, Patrick Codd

Proceedings Volume 10480, 1048006 (2018) https://doi.org/10.1117/12.2290567

KEYWORDS: Laser ablation, Natural surfaces, Laser tissue interaction, Tissues, Laser cutting, Optimization (mathematics)

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Proceedings Article | 8 February 2018 Paper

Creation of an optically tunable, solid tissue phantom for use in cancer detection

Matthew Tucker, Catherine Wallace, Sreekar Mantena, Neil Cornwell, Weston Ross, Ren Odion, Tuan Vo-Dinh, Patrick Codd

Proceedings Volume 10480, 104800H (2018) https://doi.org/10.1117/12.2290499

KEYWORDS: Tissues, Solids, Tissue optics, Cancer, Luminescence, Data modeling, Fluorescence spectroscopy, Error analysis, Principal component analysis, Surgery

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Showing 5 of 6 publications

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