Sepsis and cancer are some of the causes of morbidity and mortality in hospitals. Prompt detection and administration of the appropriate drug targeting the correct causative agent increases the chance of patient survival. The study presents an optical method supported by machine learning for discriminating urinary tract infections from an infection capable of causing urosepsis and urinary changes suggestive of bladder cancer. The method comprises spectra of spectroscopy measurement of patients' urine samples with: urinary tract infection, urosepsis and bladder cancer. To provide reliable classification of results assistance of 27 algorithms were tested. We proved that is possible to obtain up to 95% accuracy of the measurement method with the use of machine learning. The method was validated on urine samples from 93 patients. The advantages of the proposed solution are the simplicity of the sensor, mobility, versatility, and low cost of the test.
Urinary tract infections (UTIs) are prevalent clinical conditions that, if untreated, can progress to urosepsis, a potentially fatal systemic infection. Timely detection and accurate assessment are critical for effective intervention. This presentation will show the integration of Liquid Chromatography-Mass Spectrometry (LC-MS)-based metabolomics and proteomics to advance our comprehension of UTI and urosepsis. Emphasis is placed on biomarker discovery and the development of a Point-of-Care (PoC) device for urosepsis assessment using urine samples.
Numerous biological surfaces exhibit intricate micro- and nano-structures, which fulfill various functions such as anti-reflective properties, structural coloration, anti-fouling capabilities, and pro- or anti-adhesive characteristics. These features have inspired a plethora of industrial applications. In recent years, there has been a significant surge in research in this domain, largely attributable to the growing interdisciplinary nature of the approaches applied to the investigation of structured biosurfaces.
The convergence of classical zoology and botany with advances in genetics and molecular biology is noteworthy, as biologists increasingly collaborate with nanotechnologists, materials scientists, and engineers. This collaborative effort contributes significantly to expanding the horizons of research on micro- and nano-structured biological surfaces, fostering biomimetic and bioengineering applications in various industries (Fig.1). Our proposal seeks to capitalize on this momentum and align with the current developments in the field.
The primary objective of the COST Action titled "Understanding interaction light – biological surfaces: possibility for new electronic materials and devices" is to unite scientists from diverse disciplines within this dynamic research realm. The emphasis of this collaborative effort is placed on exploring the photonic effects arising from the nano- and micro-structuring of biological surfaces, along with their potential bionic applications. Through our consortium, we aim to facilitate cross-inspiration among participants from distinct research fields, fostering an environment conducive to innovation in research and eventual industrial advancements. Our initiative seeks to ride the wave of these scientific developments, propelling forward the exploration of the intricate world of micro- and nano-structured biological surfaces.
Various biological surfaces are known to be covered by elaborated micro- and nano-structures, serving a number of functions (e.g. anti-reflective, structural coloration, anti-fouling, pro- or anti-adhesive, etc.) and inspiring numerous industrial applications. Recent years have witnessed a remarkable boost in research in this field. To a large extent, this boost owes to the increasing interdisciplinary of approaches being applied to the study of structured biosurfaces. Sciences as different as classical zoology and botany are inseminated with the advances in genetics and molecular biology; biologists collaborate more and more with nanotechnologists, materials scientists and engineers – all these contribute to the widening of the horizons of research on micro- and nano-structured biological surfaces, and to biomimetic and bioengineering applications of these surfaces in industry. We aim at ‘riding the wave’ of these developments with our proposal. In our talk I will present the main goal of the COST Action “Understanding interaction light – biological surfaces: possibility for new electronic materials and devices”.
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