Glaucoma is an optic neuropathy characterized by loss of retinal ganglion cells and their axons. Glaucoma has a strong vascular component and decreased macular vessel density is known to be associated with glaucomatous damage. Adaptive optics – optical coherence tomography allows for the simultaneous quantification of vascular and ganglion cell densities. We observed a moderately strong correlation between ganglion cell and vessel densities across the macula, as well as some correlation at individual locations. Vascular density may prove to be a useful surrogate biomarker of glaucoma progression and with further study reveal new information on impairment of neurovascular coupling in glaucoma.
Microglia are central nervous system macrophages and the first responders to neural injury. Herein we characterize their distribution and motility in human eyes using a multimodal AO system. In healthy eyes, microglia are absent in the central macula up to ~5º eccentricity but their density increases monotonically at higher eccentricities. Microglia density decreases linearly with age. ILM microglia are relatively immobile for durations up to two weeks but their processes re-orient over timescales as short as minutes. The density, motility, and reactive state of microglia may serve as an ocular disease biomarker for early detection and progression monitoring.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.