Despite the technological evolutions that transform the operating rooms nowadays, a major clinical need remains: surgeons need to distinguish healthy from diseased tissues while performing a procedure. Tissue status assessment procedures such as blood perfusion monitoring require objective input that can potentially be obtained with fluorescence imaging and oxygenation imaging. We developed a multimodal imaging platform for performing widefield quantitative oxygenation imaging and fluorescence imaging in a clinical environment. We demonstrate in-vivo the impact of widefield quantitative oxygenation imaging on blood perfusion assessment. Fluorescence imaging provided by the system is used in complement to confirm the outcome of oxygenation imaging.
Tissues-mimicking phantoms are widely used for performance evaluation of imaging systems. Disease specific design of the phantom is necessary for the correct assessment of a system’s parameters. Such phantoms are a key requirement for the continued development of various imaging techniques such as optical coherence tomography (OCT), which has been successfully applied for diagnosis of diseases in the esophagus and preliminary data show that it can be also highly perspective for diagnosis of colorectal cancer. However, in vivo validation of this novel optical approach is often difficult, since the disease model development in large animals, such as pigs, is a quite challenging task. The optimal colorectal cancer phantoms should have the following criteria: 1) realized geometry in three dimensions, 2) customizable material and optical properties, 3) mounting system allowing placement in various locations of the bench-top colon model (plastic or tissue) and removal using standard endoscopic tools, 4) visual appearance compatible with white light endoscopic imaging, and 5) long term stability. To match all these criteria, we propose tissue-mimicking phantoms prepared using 3D printing and PDMS/TiO2 insertions for cancer-like regions that are covered with the layer of Dragon skin to color-match the mucosa appearance, as we believe these materials are the most promising for durable and accurate replication of tissue properties. The polyps are mounted in the colon using small neodymium magnet embedded in the base of the polyp. The developed polyps were evaluated
using optical coherence tomography system.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.