Prof. Shaoqun Zeng Profile

Prof. Shaoqun Zeng

Professor at Huazhong University of Science & Technology

SPIE Involvement:

Conference Program Committee | Author

Websites:

Company Website

Publications (113)

Proceedings Article | 18 July 2023 Paper

Label-free blood analysis utilizing contrast-enhanced defocusing imaging with machine vision

D. Chen, N. Li, X. Liu, S. Zeng, X. Lv, L. Chen, Y. Xiao, Q. Hu

Proceedings Volume 12745, 1274505 (2023) https://doi.org/10.1117/12.2682246

KEYWORDS: Blood, Machine vision, Point-of-care devices, Biomedical engineering, Optical medical imaging, Thin film diagnostics

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SPIE Journal Paper | 3 May 2023 Open Access

Ten-kilohertz two-photon microscopy imaging of single-cell dendritic activity and hemodynamics in vivo

Ruijie Li, Sibo Wang, Jing Lyu, Ke Chen, Xiaxin Sun, Junjie Huang, Pei Sun, Susu Liang, Min Li, Mengke Yang, Hongbang Liu, Shaoqun Zeng, Xiaowei Chen, Longhui Li, Hongbo Jia, Zhenqiao Zhou

NPh, Vol. 10, Issue 02, 025006, (May 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.2.025006

KEYWORDS: Calcium, Hemodynamics, Two photon imaging, Neurons, In vivo imaging, Red blood cells, Two photon excitation microscopy, Blood vessels, Video, Biological imaging

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SPIE Journal Paper | 28 November 2018 Open Access

Penetration model for chemical reactivation for resin-embedded green fluorescent protein imaging

Longhui Li, Ruixi Chen, Xiuli Liu, Ning Li, Xiaoxiang Liu, Xiaojun Wang, Tingwei Quan, Xiaohua Lv, Shaoqun Zeng

JBO, Vol. 24, Issue 05, 051406, (November 2018) https://doi.org/10.1117/12.10.1117/1.JBO.24.5.051406

KEYWORDS: Luminescence, Green fluorescent protein, Chromium, Data modeling, Brain, Diffusion, Lithium, Statistical modeling, Nerve, Optical fibers

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Proceedings Article | 14 March 2018 Presentation

Advanced NeuroGPS-Tree achieves brain-wide reconstruction of neuronal population equal to manual reconstruction level (Conference Presentation)

Tingwei Quan, Hang Zhou, Shiwei Li, Qingming Luo, Hui Gong, Anan Li, Shaoqun Zeng

Proceedings Volume 10481, 104810N (2018) https://doi.org/10.1117/12.2295110

KEYWORDS: Neurons, Neuroimaging, Brain, Neuroscience, Brain imaging, Image resolution, 3D visualizations, 3D modeling, Reconstruction algorithms

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SPIE Journal Paper | 9 February 2018 Open Access

Chemical reactivation of fluorescein isothiocyanate immunofluorescence-labeled resin-embedded samples

Longhui Li, Gong Rao, Xiaohua Lv, Ruixi Chen, Xiaofeng Cheng, Xiaojun Wang, Shaoqun Zeng, Xiuli Liu

JBO, Vol. 23, Issue 02, 020501, (February 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.020501

KEYWORDS: Luminescence, Chromium, Polymers, Tissues, Absorption, Brain, Chemical analysis, Fluorescent proteins, Neuroimaging, Lithium

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SPIE Journal Paper | 16 November 2017 Open Access

High-refractive index of acrylate embedding resin clarifies mouse brain tissue

Hongfu Zhou, Yumiao Xiong, Yu Wang, Xiaojun Wang, Pei Li, Yadong Gang, Xiuli Liu, Shaoqun Zeng

JBO, Vol. 22, Issue 11, 110503, (November 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.11.110503

KEYWORDS: Tissues, Luminescence, Brain, Refractive index, Microscopy, Tissue optics, Green fluorescent protein, Liquids, Proteins, Lithium

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SPIE Journal Paper | 27 October 2017 Open Access

Development of a neutral embedding resin for optical imaging of fluorescently labeled biological tissue

Hongfu Zhou, Yadong Gang, Shenghua Chen, Yu Wang, Yumiao Xiong, Longhui Li, Fangfang Yin, Yue Liu, Xiuli Liu, Shaoqun Zeng

JBO, Vol. 22, Issue 10, 106015, (October 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.10.106015

KEYWORDS: Luminescence, Green fluorescent protein, Tissues, Brain, Optical imaging, Polymerization, Confocal microscopy, Nerve, Tissue optics, Microscopy

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Proceedings Article | 8 February 2017 Paper

A pH-sensitive red fluorescent protein compatible with hydrophobic resin embedding

Wenyan Guo, Yadong Gang, Xiuli Liu, Hongfu Zhou, Shaoqun Zeng

Proceedings Volume 10051, 1005119 (2017) https://doi.org/10.1117/12.2250844

KEYWORDS: Fluorescent proteins, Luminescence, Imaging spectroscopy, Brain, Tomography, In vivo imaging, Biomedical optics, Photonics, Roads

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Proceedings Article | 8 February 2017 Presentation + Paper

A novel reactive resin for embedding biological tissue

Hongfu Zhou, Xiuli Liu, Yadong Gang, Xiaohua Lv, Shaoqun Zeng

Proceedings Volume 10051, 100510H (2017) https://doi.org/10.1117/12.2251267

KEYWORDS: Tissues, Luminescence, Electron microscopy, Microscopy, Epoxies, Brain mapping, Nerve, Brain, Image quality, 3D image processing, Fluorescent proteins, Biomedical optics, Photonics, Sodium

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SPIE Journal Paper | 30 November 2015 Open Access

Special Section Guest Editorial:Special Section on Light Microscopy of Connectivity

Shaoqun Zeng, Timothy Murphy

NPh, Vol. 2, Issue 04, 041401, (November 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.4.041401

KEYWORDS: Microscopy, Brain, Brain mapping, Neurons, Neuroimaging, Tissues, Spatial resolution, Confocal microscopy, Biomedical optics, Photonics

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SPIE Journal Paper | 15 October 2015 Open Access

Fluorescence micro-optical sectioning tomography using acousto-optical deflector-based confocal scheme

Xiaoli Qi, Tao Yang, Longhui Li, Jiancun Wang, Shaoqun Zeng, Xiaohua Lv

NPh, Vol. 2, Issue 04, 041406, (October 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.4.041406

KEYWORDS: Confocal microscopy, Luminescence, Brain, Signal to noise ratio, Imaging systems, Objectives, Tomography, Neuroimaging, Fluorescence tomography, Signal detection

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SPIE Journal Paper | 13 January 2015 Open Access

Fluorescence imaging of dendritic spines of Golgi-Cox-stained neurons using brightening background

Min Ai, Hanqing Xiong, Tao Yang, Zhenhua Shang, Muqing Chen, Xiuli Liu, Shaoqun Zeng

JBO, Vol. 20, Issue 01, 010501, (January 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.1.010501

KEYWORDS: Luminescence, Neurons, Spine, Brain, Confocal microscopy, Polymers, Neuroimaging, Dendrites, Microscopy, Biomedical optics

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Proceedings Article | 20 March 2014 Paper

Technical considerations on confocal based fluorescence micro-optical sectioning tomography for visualizing brain circuits

Xiaoli Qi, Xiaohua Lv, Hanqing Xiong, Cheng Yan, Jianling Chen, Hui Gong, Qingming Luo, Shaoqun Zeng

Proceedings Volume 8928, 89280T (2014) https://doi.org/10.1117/12.2036645

KEYWORDS: Brain, Neuroimaging, Confocal microscopy, Luminescence, Image resolution, Tomography, Imaging systems, Fluorescence tomography, Biomedical optics, Visualization

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SPIE Journal Paper | 11 June 2013 Open Access

Fast optical sectioning obtained by structured illumination microscopy using a digital mirror device

Dongli Xu, Tao Jiang, Anan Li, Bihe Hu, Zhao Feng, Hui Gong, Shaoqun Zeng, Qingming Luo

JBO, Vol. 18, Issue 06, 060503, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.060503

KEYWORDS: Brain, Digital micromirror devices, Mirrors, Microscopy, Neuroimaging, Imaging systems, 3D image processing, Biomedical optics, Luminescence, Neuroscience

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SPIE Journal Paper | 28 May 2013 Open Access

Improved detectability of neuronal connectivity on mechanical sectioning setup by using confocal detection

Xiaoli Qi, Hanqing Xiong, Xiaohua Lv, Jianling Chen, Hui Gong, Qingming Luo, Shaoqun Zeng

JBO, Vol. 18, Issue 05, 050506, (May 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.5.050506

KEYWORDS: Confocal microscopy, Signal detection, Luminescence, Optical tomography, Tomography, Imaging systems, Neuroimaging, Brain, Image resolution, Mechanics

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Proceedings Article | 26 November 2012 Paper

Optical path difference characteristics of the fluorescence holographic system

Xiaomin Lai, Shaoqun Zeng

Proceedings Volume 8556, 855617 (2012) https://doi.org/10.1117/12.2001375

KEYWORDS: Wavefronts, Spatial light modulators, Luminescence, Holography, Holograms, Spherical lenses, Signal to noise ratio, Objectives, Cameras, CCD cameras

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SPIE Journal Paper | 6 April 2012 Open Access

Errata: Localization capability and limitation of electron-multiplying charge-coupled, scientific complementary metal-oxide semiconductor, and charge-coupled devices for superresolution imaging

Tingwei Quan, Shaoqun Zeng, Zhen-Li Huang

JBO, Vol. 17, Issue 04, 049801, (April 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.4.049801

KEYWORDS: Semiconductors, Charge-coupled devices, Super resolution, Imaging devices, Biomedical optics, Optoelectronics, Photonics, Mathematics

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SPIE Journal Paper | 1 August 2011 Open Access

Identification of the direction of the neural network activation with a cellular resolution by fast two-photon imaging

Xiuli Liu, Tingwei Quan, Shaoqun Zeng, Xiaohua Lv

JBO, Vol. 16, Issue 08, 080506, (August 2011) https://doi.org/10.1117/12.10.1117/1.3613918

KEYWORDS: Calcium, Neurons, Signal to noise ratio, Neural networks, Brain, Two photon imaging, Image resolution, Error analysis, Spatial resolution, Two photon excitation microscopy

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SPIE Journal Paper | 1 May 2011 Open Access

Confocal imaging reveals three-dimensional fine structure difference between ventral and dorsal nerve roots

Yuxiang Wu, Xiaohua Lv, Shaoqun Zeng, Tao Sui, Xiaojian Cao, Peng Sun

JBO, Vol. 16, Issue 05, 050502, (May 2011) https://doi.org/10.1117/12.10.1117/1.3575167

KEYWORDS: Nerve, Optical fibers, Confocal microscopy, 3D image processing, Laser scanners, Injuries, 3D image reconstruction, Biomedical optics, Photonics, Tissues

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SPIE Journal Paper | 1 November 2010 Open Access

Method to reconstruct neuronal action potential train from two-photon calcium imaging

Tingwei Quan, Xiuli Liu, Xiaohua Lv, Wei Chen, Shaoqun Zeng

JBO, Vol. 15, Issue 06, 066002, (November 2010) https://doi.org/10.1117/12.10.1117/1.3505021

KEYWORDS: Calcium, Luminescence, Reconstruction algorithms, Action potentials, Neurons, Deconvolution, Signal to noise ratio, In vivo imaging, Convolution, Linear filtering

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SPIE Journal Paper | 1 November 2010 Open Access

Localization capability and limitation of electron-multiplying charge-coupled, scientific complementary metal-oxide semiconductor, and charge-coupled devices for superresolution imaging

Tingwei Quan, Shaoqun Zeng, Zhenli Huang

JBO, Vol. 15, Issue 06, 066005, (November 2010) https://doi.org/10.1117/12.10.1117/1.3505017

KEYWORDS: Sensors, Cameras, Electron multiplying charge coupled devices, Molecules, Super resolution, CCD cameras, Signal detection, Photodetectors, CCD image sensors, Point spread functions

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SPIE Journal Paper | 1 May 2010 Open Access

Characteristics of calcium signaling in astrocytes induced by photostimulation with femtosecond laser

Yuan Zhao, Yuan Zhang, Wei Zhou, Xiuli Liu, Shaoqun Zeng, Qingming Luo

JBO, Vol. 15, Issue 03, 035001, (May 2010) https://doi.org/10.1117/12.10.1117/1.3454390

KEYWORDS: Calcium, Femtosecond phenomena, Photostimulation, Acquisition tracking and pointing, Wave propagation, Luminescence, Brain, Receptors, Neurons, Ions

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Proceedings Article | 25 February 2009 Paper

Real-time optical imaging of the interaction of epidermal growth factor and its receptor in living cells

Qiaoya Lin, Liang Wang, Shaoqun Zeng, Zhihong Zhang, Gang Zheng

Proceedings Volume 7178, 71780P (2009) https://doi.org/10.1117/12.811372

KEYWORDS: Fluorescence resonance energy transfer, Receptors, Green fluorescent protein, Signal detection, Visualization, Optical imaging, Proteins, Molecules, Bandpass filters, Cancer

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Proceedings Article | 17 February 2009 Paper

A new red bimolecular fluorescence complementation based on TagRFP

Lingsong Qin, Jun Chu, Ying Zheng, Qingming Luo, Shaoqun Zeng, Zhihong Zhang

Proceedings Volume 7191, 71910G (2009) https://doi.org/10.1117/12.811375

KEYWORDS: Luminescence, Proteins, Fluorescent proteins, Ferroelectric materials, In vivo imaging, Visualization, Visual analytics, Chromophores, Molecular mechanisms, Signal processing

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Proceedings Article | 12 February 2009 Paper

The generation of the synchronized burst in the cultured neuronal networks

Xiangning Li, Jing Sun, Wenjuan Chen, Shaoqun Zeng, Qingming Luo

Proceedings Volume 7176, 71760H (2009) https://doi.org/10.1117/12.812343

KEYWORDS: Neurons, Electrodes, Brain, In vitro testing, Lithium, Data processing, Neural networks, Sun, Receptors, Raster graphics

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SPIE Journal Paper | 1 May 2008 Open Access

Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system

Zhihong Zhang, Juqiang Lin, Jun Chu, Yan Ma, Shaoqun Zeng, Qingming Luo

JBO, Vol. 13, Issue 03, 031209, (May 2008) https://doi.org/10.1117/12.10.1117/1.2937830

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Cell death, Multichannel imaging systems, Imaging systems, Green fluorescent protein, Proteins, Fluorescent proteins, Image fusion, Optoelectronics

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Proceedings Article | 18 March 2008 Paper

The effects of respiration motion in PET/CT studies

Lu Wan, Zhijian Wu, Fengyin Zhou, Sheng Ye, Shaoqun Zeng, Chien-Min Kao, Chin-Tu Chen, Yongxue Zhang, Qingguo Xie

Proceedings Volume 6913, 69134A (2008) https://doi.org/10.1117/12.769705

KEYWORDS: Positron emission tomography, Signal attenuation, Monte Carlo methods, Computed tomography, Tissues, Lung cancer, Expectation maximization algorithms, Chest imaging, Computer simulations, Fuzzy logic

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Proceedings Article | 14 March 2008 Paper

Effects of sciatic nerve stimulation on the propagation of cortical spreading depression

Xiaoli Sun, Zhidong Yu, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proceedings Volume 6863, 68630U (2008) https://doi.org/10.1117/12.763372

KEYWORDS: Nerve, Electrodes, Brain stimulation, Brain, Epilepsy, Electrophysiology, Ischemia, Optical imaging, Modulation, Positron emission tomography

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Proceedings Article | 28 February 2008 Paper

Enlarging the linear response range of velocity with optimum imaging parameters and modified data processing in laser speckle imaging

Jianjun Qiu, Pengcheng Li, Sergey Ul'yanov, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6863, 68630T (2008) https://doi.org/10.1117/12.763355

KEYWORDS: Speckle, CCD cameras, Laser speckle imaging, Speckle pattern, Velocity measurements, Microscopy, Data processing, Imaging systems, Blood circulation, Cerebral blood flow

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Proceedings Article | 6 February 2008 Paper

Bifurcation and chaos in the spontaneously firing spike train of cultured neuronal network

Wenjuan Chen, Xiangning Li, Geng Zhu, Wei Zhou, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6855, 68550E (2008) https://doi.org/10.1117/12.763403

KEYWORDS: Chaos, Time series analysis, Neurons, Neuroscience, Biomedical optics, Photonics, Neural networks, Stochastic processes, Brain mapping, Lithium

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Proceedings Article | 6 February 2008 Paper

Conversion coefficients for external monoenergic photon beams in the visible Chinese human model

Qian Liu, Guozhi Zhang, Shaoqun Zeng

Proceedings Volume 6855, 68550J (2008) https://doi.org/10.1117/12.763417

KEYWORDS: Mathematical modeling, Data modeling, Tissues, Particles, Intestine, Bone, Radiation dosimetry, Radiation effects, Skin, Bladder

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Proceedings Article | 8 January 2008 Paper

Measurement of caspase-2 activation during different anti-tumor drugs induced apoptosis by FRET technique

Juqiang Lin, Shaoqun Zeng, Qingming Luo, Chen Rong, Zhihong Zhang

Proceedings Volume 6826, 682630 (2008) https://doi.org/10.1117/12.757313

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Fluorescent proteins, Cancer, Biomedical optics, Proteins, Optoelectronics, Imaging systems, Medicine, Photonics

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SPIE Journal Paper | 1 January 2008 Open Access

Fluorescence imaging to assess the matrix metalloproteinase activity and its inhibitor in vivo

Zhihong Zhang, Jie Yang, Jinling Lu, Juqiang Lin, Shaoqun Zeng, Qingming Luo

JBO, Vol. 13, Issue 01, 011006, (January 2008) https://doi.org/10.1117/12.10.1117/1.2830659

KEYWORDS: Luminescence, Tumors, In vivo imaging, Sensors, Proteins, Fluorescence resonance energy transfer, Content addressable memory, Signal detection, Confocal microscopy, Imaging systems

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SPIE Journal Paper | 1 November 2007 Open Access

Effect of light losses of sample between two integrating spheres on optical properties estimation

Dan Zhu, Wei Lu, Shaoqun Zeng, Qingming Luo

JBO, Vol. 12, Issue 06, 064004, (November 2007) https://doi.org/10.1117/12.10.1117/1.2815691

KEYWORDS: Error analysis, Absorption, Optical properties, Scattering, Statistical analysis, Integrating spheres, Light scattering, Distributed interactive simulations, Anisotropy, Tissue optics

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Proceedings Article | 1 May 2007 Paper

Synchronies in cultured neuronal network

Yunsheng Lin, Lin Chen, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6534, 65343D (2007) https://doi.org/10.1117/12.741466

KEYWORDS: Signal processing, Neurons, Brain, Signal detection, Electrodes, In vitro testing, Action potentials, Photonics, Data processing, Binary data

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Proceedings Article | 1 May 2007 Paper

Enhancement of spontaneous burst activity of hippocampal neuronal networks with low frequency close-loop stimulation

Yanling Li, Wei Zhou, Shaoqun Zeng, Xiangning Li, Man Liu, Qingming Luo

Proceedings Volume 6534, 65343C (2007) https://doi.org/10.1117/12.741465

KEYWORDS: Neurons, Electrodes, Action potentials, In vitro testing, Modulation, Synaptic transmission, Plating, Brain, Glia, Lithium

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Proceedings Article | 1 May 2007 Paper

Dynamic imaging of cerebral blood flow in rat reperfused mini-stroke model using laser speckle temporal contrast analysis

Zhen Wang, Weihua Luo, Pengcheng Li, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6534, 65343N (2007) https://doi.org/10.1117/12.741504

KEYWORDS: Speckle, Cerebral blood flow, Ischemia, Somatosensory cortex, Laser tissue interaction, Spatial resolution, Brain, Blood circulation, Laser speckle imaging, Laser scattering

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Proceedings Article | 1 May 2007 Paper

Restoration of fluorescence images from two-photon microscopy using modified nonlinear anisotropic diffusion filter

Hongmin Zhang, Qingming Luo, Shaoqun Zeng

Proceedings Volume 6534, 65343H (2007) https://doi.org/10.1117/12.741498

KEYWORDS: Diffusion, Luminescence, Anisotropic diffusion, Nonlinear filtering, Neurons, Anisotropic filtering, Image filtering, Two photon excitation microscopy, Laser scanners, Image restoration

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SPIE Journal Paper | 1 March 2007 Open Access

Analysis of the dispersion compensation of acousto-optic deflectors used for multiphoton imaging

Shaoqun Zeng, Xiaohua Lv, Kun Bi, Chen Zhan, Derong Li, Wei Chen, Wenhui Xiong, Steven Jacques, Qingming Luo

JBO, Vol. 12, Issue 02, 024015, (March 2007) https://doi.org/10.1117/12.10.1117/1.2714061

KEYWORDS: Prisms, Bragg cells, Acousto-optics, Adaptive optics, Scanners, Multiphoton microscopy, Biological research, Luminescence, Optical components, Pulsed laser operation

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Proceedings Article | 15 February 2007 Paper

Elicitation interval dependent spatiotemporal evolution of cortical spreading depression waves revealed by optical intrinsic signal imaging

Shangbin Chen, Hui Gong, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proceedings Volume 6445, 64450R (2007) https://doi.org/10.1117/12.701699

KEYWORDS: Wave propagation, Reflectivity, Optical imaging, Light wave propagation, Potassium, Blood, Biomedical optics, Tissues, Electrodes, Image acquisition

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Proceedings Article | 15 February 2007 Paper

A preliminary study on determining the time window of hypothermia cerebral protection in rat cortex by laser speckle flowmetry

Wenjia Wang, Qiang Li, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proceedings Volume 6445, 64450Q (2007) https://doi.org/10.1117/12.701609

KEYWORDS: Veins, Arteries, Blood, Cerebral blood flow, Laser speckle imaging, Blood circulation, Speckle, Therapeutics, Laser scattering, Hemodynamics

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Proceedings Article | 7 February 2007 Paper

Richardson-Lucy deconvolution for two-photon fluorescence images via non-linear diffusion equation pre-filtering

Hongmin Zhang, Zhitao Zhang, Qingming Luo, Shaoqun Zeng

Proceedings Volume 6436, 64360P (2007) https://doi.org/10.1117/12.701750

KEYWORDS: Deconvolution, Point spread functions, Luminescence, Diffusion, Microscopy, Two photon excitation microscopy, Anisotropic diffusion, Image processing, Laser scanners, In vivo imaging

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Proceedings Article | 7 February 2007 Paper

Evaluation the development of focal cerebral ischemia in rats by optical imaging based on the spreading depression signals

Shangbin Chen, Zhe Feng, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proceedings Volume 6436, 64360A (2007) https://doi.org/10.1117/12.701636

KEYWORDS: Ischemia, Reflectivity, Brain, Optical imaging, Arteries, Spatial resolution, Wave propagation, Neuroimaging, Biomedical optics, Optical resolution

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Proceedings Article | 27 October 2006 Paper

Monitoring apoptosis of TK-GFP-expressing ACC-M cells induced by ACV using FRET technique

Tao Xiong, Zhihong Zhang, Juqiang Lin, Jie Yang, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6047, 60472J (2006) https://doi.org/10.1117/12.710962

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Tumors, Fluorescent proteins, Green fluorescent protein, Tissues, Proteins, Luminescence, Microscopy, Photonics

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SPIE Journal Paper | 1 July 2006 Open Access

Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis

Juqiang Lin, Zhihong Zhang, Jie Yang, Shaoqun Zeng, Bifeng Liu, Qingming Luo

JBO, Vol. 11, Issue 02, 024011, (July 2006) https://doi.org/10.1117/12.10.1117/1.2187013

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Proteins, Fluorescent proteins, In vitro testing, Luminescence, Spectroscopy, Imaging systems, Bacteria, Biomedical optics

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SPIE Journal Paper | 1 July 2006 Open Access

Errata: Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis

Juqiang Lin, Zhihong Zhang, Shaoqun Zeng, Bifeng Liu, Qingming Luo, Jie Yang

JBO, Vol. 11, Issue 04, 049801, (July 2006) https://doi.org/10.1117/12.10.1117/1.2219117

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Proceedings Article | 19 May 2006 Paper

Monitoring apoptosis of TK-GFP-expressing ACC-M cells induced by ACV using FRET technique

Tao Xiong, Zhihong Zhang, Juqiang Lin, Jie Yang, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6218, 62180L (2006) https://doi.org/10.1117/12.662591

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Tumors, Green fluorescent protein, Fluorescent proteins, Tissues, Proteins, Luminescence, Microscopy, Cell mechanics

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SPIE Journal Paper | 1 May 2006 Open Access

In vivo optical reflectance imaging of spreading depression waves in rat brain with and without focal cerebral ischemia

Shangbin Chen, Zhe Feng, Pengcheng Li, Steven Jacques, Shaoqun Zeng, Qingming Luo

JBO, Vol. 11, Issue 03, 034002, (May 2006) https://doi.org/10.1117/12.10.1117/1.2203654

KEYWORDS: Reflectivity, Brain, Neuroimaging, Blood, Optical imaging, Ischemia, Arteries, Skull, In vivo imaging, Biomedical optics

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Proceedings Article | 3 March 2006 Paper

Combine temporal clustering analysis with least square estimation to determine the dynamic pattern of cortical spreading depression

Shangbin Chen, Pengcheng Li, Hui Gong, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6085, 60850D (2006) https://doi.org/10.1117/12.644125

KEYWORDS: Wave propagation, Binary data, Optical imaging, Functional magnetic resonance imaging, Image analysis, Reflectivity, Blood, Statistical analysis, Lead, Biomedical optics

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Proceedings Article | 3 March 2006 Paper

Analysis of synchrony in cultured neuronal network

Yunsheng Lin, Lin Chen, Wei Zhou, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6085, 60850H (2006) https://doi.org/10.1117/12.647187

KEYWORDS: Neurons, Signal processing, Signal detection, Brain, Electrodes, In vitro testing, Action potentials, Biomedical optics, Photonics, In vivo imaging

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Proceedings Article | 3 March 2006 Paper

Responses of cultured neuronal network to different electrical stimuli patterns

Lin Chen, Chuanping Chen, Yunsheng Lin, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6085, 60850G (2006) https://doi.org/10.1117/12.647176

KEYWORDS: Neurons, Electrodes, Modulation, Data acquisition, Biomedical optics, Photonics, In vitro testing, Electrophysiology, Microelectronics, Network security

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Proceedings Article | 3 March 2006 Paper

Frame self-division applied in analysis of intrinsic signal optical imaging data

Weihua Luo, Pengcheng Li, Li Zhang, Xiaohua Lv, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6085, 60850E (2006) https://doi.org/10.1117/12.645570

KEYWORDS: Optical imaging, Interference (communication), Signal to noise ratio, Image processing, Data processing, Biomedical optics, Signal analyzers, Photonics, Data analysis, Light

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Proceedings Article | 3 March 2006 Paper

Analyzing the origin of spontaneous synchronized burst in cultured neuronal networks on MEA

Chuanping Chen, Lin Chen, Yunsheng Lin, Shaoqun Zeng

Proceedings Volume 6085, 60850F (2006) https://doi.org/10.1117/12.647101

KEYWORDS: Neurons, Electrodes, Nervous system, Electrophysiology, Action potentials, In vitro testing, Signal detection, Biomedical optics, Photonics, Dendrites

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Proceedings Article | 22 February 2006 Paper

Application of a FRET probe for Caspase-3 activation in living HeLa cells by sequentially treated cisplatin and TRAIL

Juqiang Lin, Zhihong Zhang, Qiushi Yi, Shaoqun Zeng, Qingming Luo

Proceedings Volume 6088, 60881K (2006) https://doi.org/10.1117/12.647151

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Proteins, Tumors, Cancer, Luminescence, Fluorescent proteins, Imaging systems, Resonance enhancement, Tissues

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Proceedings Article | 29 March 2005 Paper

Verbal working memory load affects prefrontal cortices activation: evidence from a functional NIRS study in humans

Chengjun Li, Hui Gong, Shaoqun Zeng, Qingming Luo

Proceedings Volume 5696, (2005) https://doi.org/10.1117/12.590222

KEYWORDS: Near infrared spectroscopy, Hemodynamics, Imaging systems, Positron emission tomography, Prefrontal cortex, Brain, Neuroimaging, Functional magnetic resonance imaging, Light emitting diodes, Sensors

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Proceedings Article | 29 March 2005 Paper

Using threshold segmentation methods to measure dynamic vasodilatation in a series of optical images

Shangbin Chen, Pengcheng Li, Shaoqun Zeng, Qingming Luo

Proceedings Volume 5696, (2005) https://doi.org/10.1117/12.589795

KEYWORDS: Image segmentation, Arteries, Hemodynamics, Algorithm development, Intrinsic optical signal imaging, Optical imaging, Blood, Stars, Image processing, Biomedical optics

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Proceedings Article | 29 March 2005 Paper

Enhancement of synaptic transmission induced by BDNF in cultured cortical neurons

Jun He, Hui Gong, Shaoqun Zeng, Yanling Li, Qingming Luo

Proceedings Volume 5696, (2005) https://doi.org/10.1117/12.592072

KEYWORDS: Calcium, Neurons, Synaptic transmission, Receptors, Sodium, Cadmium, Synaptic plasticity, Luminescence, Action potentials, Photonics

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Proceedings Article | 18 January 2005 Paper

Compact whole-body fluorescent imaging of nude mice bearing EGFP expressing tumor

Yanping Chen, Tao Xiong, Jun Chu, Li Yu, Shaoqun Zeng, Qingming Luo

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.580663

KEYWORDS: Tumors, Luminescence, Green fluorescent protein, Lung, Lamps, In vivo imaging, Mercury, Optical imaging, Visualization, Fluorescent proteins

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Proceedings Article | 18 January 2005 Paper

Fluorescence correlation spectroscopy considering the effect of photobleaching

Yafeng Liu, Tongsheng Chen, Qingming Luo, Shaoqun Zeng

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.580645

KEYWORDS: Molecules, Luminescence, Fluorescence correlation spectroscopy, Diffusion, Biomedical optics, Sensors, Molecular spectroscopy, Tissue optics, Signal to noise ratio, Time metrology

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Proceedings Article | 8 December 2003 Paper

Optical imaging of neural activity: from neuron to brain

Qingming Luo, Shaoqun Zeng, Hui Gong

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546095

KEYWORDS: Brain, Optical imaging, Neuroimaging, Neurons, Imaging systems, Tissue optics, Near infrared spectroscopy, Functional magnetic resonance imaging, Light scattering, Signal detection

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Proceedings Article | 8 December 2003 Paper

Photobleaching of fluorophores at lower concentration under two-photon excitation microscopy

Tongsheng Chen, Yafeng Liu, Shaoqun Zeng, Qingming Luo

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546559

KEYWORDS: Molecules, Rhodamine B, Luminescence, Absorption, Photons, Two photon excitation microscopy, Photonics, Bioalcohols, Oxygen, Molecular interactions

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Proceedings Article | 8 December 2003 Paper

Calcium imaging of cultured neuronal network on multi-electrode array (MEA)

Wei Zhou, Xiangning Li, Shaoqun Zeng, Qingming Luo

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546570

KEYWORDS: Calcium, Neurons, Electrodes, Glasses, Plating, Optical filters, Cell mechanics, Confocal microscopy, Imaging systems, Luminescence

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Proceedings Article | 8 December 2003 Paper

On short-term memory of prefrontal cortex using near-infrared spectroscopy

Chengjun Li, Zhuo Gan, Hui Gong, Qingming Luo, Shaoqun Zeng

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546564

KEYWORDS: Near infrared spectroscopy, Prefrontal cortex, Blood, Brain, Positron emission tomography, Imaging systems, Near infrared, Functional magnetic resonance imaging, Light sources, Sensors

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Proceedings Article | 8 December 2003 Paper

Capillary electrophoresis based on continuous-wave multiphoton excitation fluorescence

Sheng Chen, Qingming Luo, Shaoqun Zeng, Tongsheng Chen, Hui Gong, Ling Fu

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546117

KEYWORDS: Capillaries, Luminescence, Continuous wave operation, Femtosecond phenomena, Rhodamine B, Semiconductor lasers, Molecules, Mode locking, Biological research

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Proceedings Article | 4 December 2003 Paper

Probe dendritic functions through poking and peeking

Wenhui Xiong, Zhishang Zhou, Shaoqun Zeng, Wei Chen

Proceedings Volume 5255, (2003) https://doi.org/10.1117/12.546236

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Proceedings Article | 4 December 2003 Paper

Tissue elaborate structure data collection by a high-resolution optical method and image reconstruction

Rongbing Sheng, Qingming Luo, Dan Zhu, Shaoqun Zeng

Proceedings Volume 5255, (2003) https://doi.org/10.1117/12.546246

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Proceedings Article | 13 October 2003 Paper

Spatio-temporal characteristics of cerebral blood volume changes in different microvascular compartments evoked by sciatic nerve stimulation in rat somatosensory cortex

Pengcheng Li, Qingming Luo, Weihua Luo, Shangbin Chen, Haiying Chen, Shaoqun Zeng

Proceedings Volume 5068, (2003) https://doi.org/10.1117/12.518783

KEYWORDS: Blood, Nerve, Arteries, Capillaries, Optical imaging, Somatosensory cortex, Reflectivity, Veins, Skull, Sensors

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SPIE Journal Paper | 1 October 2003 Open Access

Spatiotemporal characteristics of cerebral blood volume changes in rat somatosensory cortex evoked by sciatic nerve stimulation and obtained by optical imaging

Pengcheng Li, Qingming Luo, Weihua Luo, Shangbin Chen, Haiying Cheng, Shaoqun Zeng

JBO, Vol. 8, Issue 04, (October 2003) https://doi.org/10.1117/12.10.1117/1.1609199

KEYWORDS: Blood, Nerve, Reflectivity, Optical imaging, Veins, Capillaries, Arteries, Somatosensory cortex, Skull, Sensors

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Proceedings Article | 12 September 2003 Paper

High-order photobleaching in two-photon excitation fluorescence microscopy inside live cell

Tongsheng Chen, Shaoqun Zeng, Qingming Luo, Wei Zhou, Zhihong Zhang

Proceedings Volume 4967, (2003) https://doi.org/10.1117/12.477882

KEYWORDS: Luminescence, Microscopy, Green fluorescent protein, Multiphoton microscopy, In vivo imaging, Molecules, Proteins, Multiphoton fluorescence microscopy, Biomedical optics, Microscopes

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Proceedings Article | 12 September 2003 Paper

Interaction method of photobleaching produced by the interaction between excitation photons and fluorophore molecules in excited states

Tongsheng Chen, Shaoqun Zeng, Qingming Luo

Proceedings Volume 4967, (2003) https://doi.org/10.1117/12.478400

KEYWORDS: Molecules, Photons, Molecular interactions, Luminescence, Absorption, Molecular photonics, Biomedical optics, Biological research, Diffusion, Green fluorescent protein

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Proceedings Article | 27 August 2003 Paper

Dynamic measurement of blood flow with optical methods

Ting Zhang, Dan Zhu, Qingming Luo, Shaoqun Zeng, Yang Weng

Proceedings Volume 4961, (2003) https://doi.org/10.1117/12.477691

KEYWORDS: Blood, Tissues, Blood circulation, Velocity measurements, Speckle, Temperature metrology, Intestine, Charge-coupled devices, Tumors, Body temperature

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Proceedings Article | 27 August 2003 Paper

Dehydration effect on optical properties of porcine liver

Dan Zhu, Qingming Luo, Jian Cen, Shaoqun Zeng, Xiaohua Lu, Yang Weng

Proceedings Volume 4961, (2003) https://doi.org/10.1117/12.477661

KEYWORDS: Optical properties, Scattering, Absorption, Liver, Tissues, Tissue optics, Laser tissue interaction, Laser scattering, Temperature metrology, Integrating spheres

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Proceedings Article | 29 July 2003 Paper

Spatiotemporal characteristics of cerebral blood volume changes in different microvascular compartments evoked by sciatic nerve stimulation in rat somatosensory cortex

Pengcheng Li, Qingming Luo, Weihua Luo, Shanbin Chen, Haiying Cheng, Shaoqun Zeng

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478130

KEYWORDS: Blood, Nerve, Arteries, Capillaries, Optical imaging, Somatosensory cortex, Reflectivity, Veins, Skull, Sensors

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Proceedings Article | 29 July 2003 Paper

Detection of time window of cerebral blood flow response induced by sciatic nerve stimulation using temporal clustering analysis

Zheng Wang, Qingming Luo, Haiying Cheng, Shaoqun Zeng

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478128

KEYWORDS: Nerve, Brain, Cerebral blood flow, Functional magnetic resonance imaging, Neuroimaging, Optical imaging, Signal to noise ratio, Speckle, In vivo imaging, Blood

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Proceedings Article | 8 July 2003 Paper

Monitoring the regional blood flow in the rat mesentery under the drug's effect by using laser speckle imaging

Haiying Cheng, Qingming Luo, Zheng Wang, Shaoqun Zeng, Jian Cen, Pengcheng Li

Proceedings Volume 4956, (2003) https://doi.org/10.1117/12.477779

KEYWORDS: Blood circulation, Speckle, Laser speckle imaging, Velocity measurements, Blood, Spatial resolution, Doppler effect, Transparency, Speckle pattern, Charge-coupled devices

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SPIE Journal Paper | 1 July 2003 Open Access

Modified laser speckle imaging method with improved spatial resolution

Haiying Cheng, Qingming Luo, Shaoqun Zeng, Shangbin Chen, Jian Cen, Hui Gong

JBO, Vol. 8, Issue 03, (July 2003) https://doi.org/10.1117/12.10.1117/1.1578089

KEYWORDS: Blood circulation, Speckle, Spatial resolution, Blood, Speckle pattern, Laser speckle imaging, Temporal resolution, Doppler effect, Statistical analysis, Cerebral blood flow

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