Ms. Sing Wei Lau Profile

Sing Wei Lau

at Nanyang Technological Univ

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Proceedings Article | 5 March 2021 Poster + Presentation + Paper

A study of the effect of microbubbles with different gas cores and saline solution on microbubbles-assisted sonothrombolysis via combined ultrasound and photoacoustic imaging

Dhiman Das, Sing Wei Lau, Manojit Pramanik

Proceedings Volume 11642, 116424H (2021) https://doi.org/10.1117/12.2578048

KEYWORDS: Blood, Ultrasonography, Photoacoustic imaging, Sulfur, Polyurethane, Optical microscopy, Interfaces, Gases, Acoustics

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Degradation of blood clots using microbubbles and acoustic waves is regarded as microbubbles-assisted sonothrombolysis. This process can be monitored using dual modal clinical ultrasound and photoacoustic imaging. A greater understanding is crucial on how different gas cores of microbubbles and whether the presence of saline in the surfactant solution can affect the stability of microbubbles for sonothrombolysis. In this project, a work on using microbubbles with different gas cores and the effect of saline in the external surfactant solution during microbubbles-assisted sonothrombolysis is reported. To understand the stability of the microbubbles, analysis of the number of microbubbles in surfactant solution was conducted using optical microscopy. Two different gases, sulfur hexafluoride (SF₆) gas and decafluorobutane (C4_F₁₀) gas were used in this study to examine the effects of microbubbles on sonothrombolysis for blood clot removal. Two different bases: deionized (DI) water and saline in the microbubbles’ external surfactant solution were also used in this study to examine the stability of the microbubbles. A high-shear rotor homogenizer was used to synthesize the microbubbles. Porcine blood was used for clot formation in polyurethane tubes. The clot-containing tube was set up and submerged in water tank. It was first subjected to microbubbles treatment and next sonothrombolysis treatment for a total of one hour, with the microbubbles being introduced at the interface of the blood clot simultaneously during the sonothrombolysis treatment. The mass of the treated blood clot was then obtained by weighing it with an analytical balance and the change in mass can be obtained by comparison with the initial mass of blood clot. Percentage change in mass of the blood clot was then calculated and a greater percentage change correlated with a greater sonothrombolysis effect.

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