Dr. Steven S. Jones Profile

Dr. Steven S. Jones

at Lawrence Livermore National Lab

SPIE Involvement:

Author

Publications (25)

Proceedings Article | 9 March 2012 Paper

In-vivo imaging of inner retinal cellular morphology with adaptive optics - optical coherence tomography: challenges and possible solutions

Robert Zawadzki, Steven Jones, Dae Yu Kim, Lisa Poyneer, Arlie Capps, Bernd Hamann, Scot Olivier, John Werner

Proceedings Volume 8209, 82091G (2012) https://doi.org/10.1117/12.907678

KEYWORDS: Adaptive optics optical coherence tomography, Optical coherence tomography, Data acquisition, Adaptive optics, Retina, Speckle, Visualization, Imaging systems, Retinal scanning, Scanning laser ophthalmoscopy

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Proceedings Article | 3 November 2011 Paper

Application of a new high-speed magnetic deformable mirror for in-vivo retinal imaging

Sandra Balderas-Mata, Steven Jones, Robert Zawadzki, John Werner

Proceedings Volume 8011, 801195 (2011) https://doi.org/10.1117/12.903365

KEYWORDS: Adaptive optics, Eye, In vivo imaging, Retina, Cameras, Actuators, Imaging systems, Floods, Deformable mirrors, Mirrors

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Nowadays in ophthalmologic practice several commercial instruments are available to image patient retinas in vivo. Many modern fundus cameras and confocal scanning laser ophthalmoscopes allow acquisition of two dimensional en face images of the retina with both back reflected as well as fluorescent light. Additionally, optical coherence tomography systems allow non-invasive probing of three-dimensional retinal morphology. For all of these instruments the available lateral resolution is limited by optical quality of the human eye used as the imaging objective. To improve lateral resolution and achieve diffraction-limited imaging, adaptive optics (AO) can be implemented with any of these imaging systems to correct both static and dynamic aberrations inherent in human eyes. Most of the wavefront correctors used previously in AO systems have limited dynamic range and an insufficient number of actuators to achieve diffraction-limited correction of most human eyes. Thus, additional corrections were necessary, either by trial lenses or additional deformable mirrors (DMs). The UC Davis AO flood-illuminated fundus camera system described in this paper has been previously used to acquire in vivo images of the photoreceptor mosaic and for psychophysical studies on normal and diseased retinas. These results were acquired using a DM manufactured by Litton ITEK (DM109), which has 109 actuators arranged in a hexagonal array below a continuous front-surface mirror. It has an approximate surface actuator stroke of ±2μm. Here we present results with a new hi-speed magnetic DM manufactured by ALPAO (DM97, voice coil technology), which has 97 actuators and similar inter-actuator stroke (>3μm, mirror surface) but much higher low-order aberration correction (defocus stroke of at least ±30μm) than the previous one. In this paper we report results of testing performance of the ALPAO DM for the correction of human eye aberrations. Additionally changes made to our AO flood illuminated system are presented along with images of the model eye retina and in-vivo human retina acquired with this system.

Proceedings Article | 10 March 2011 Paper

AO-OCT with reference arm phase shifting for complex conjugate artifact-free imaging of in vivo retinal structures

Robert Zawadzki, Dae Yu Kim, Steven Jones, Suman Pilli, Scot Olivier, John Werner

Proceedings Volume 7885, 78850B (2011) https://doi.org/10.1117/12.873955

KEYWORDS: Adaptive optics optical coherence tomography, In vivo imaging, Mirrors, Phase shifting, Optical coherence tomography, Phase shifts, Adaptive optics, Imaging systems, Reconstruction algorithms, Optical filters

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Proceedings Article | 11 February 2011 Paper

The use of a high-order MEMS deformable mirror in the Gemini Planet Imager

Lisa Poyneer, Brian Bauman, Steven Cornelissen, Joshua Isaacs, Steven Jones, Bruce Macintosh, David Palmer

Proceedings Volume 7931, 793104 (2011) https://doi.org/10.1117/12.876496

KEYWORDS: Actuators, Microelectromechanical systems, Gemini Planet Imager, Coronagraphy, Adaptive optics, Mirrors, Calibration, Wavefronts, Spatial frequencies, Signal to noise ratio

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Proceedings Article | 3 March 2010 Paper

Retinal imaging with a combined adaptive optics/optical coherence tomography and adaptive optics/scanning laser ophthalmoscopy system

Robert Zawadzki, Steven Jones, Suman Pilli, Dae Yu Kim, Scot Olivier, John Werner

Proceedings Volume 7550, 75500Z (2010) https://doi.org/10.1117/12.842946

KEYWORDS: Scanning laser ophthalmoscopy, Optical coherence tomography, Adaptive optics, Adaptive optics optical coherence tomography, Imaging systems, Retinal scanning, Deformable mirrors, Mirrors, Data acquisition, Eye

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Proceedings Article | 24 February 2009 Paper

Performance of a MEMS-based AO-OCT system using Fourier reconstruction

Julia Evans, Robert Zawadzki, Steve Jones, Scot Olivier, John Werner

Proceedings Volume 7209, 720905 (2009) https://doi.org/10.1117/12.808002

KEYWORDS: Wavefronts, Adaptive optics, Microelectromechanical systems, Error analysis, Actuators, Control systems, Photons, Deformable mirrors, Eye, Adaptive optics optical coherence tomography

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Proceedings Article | 18 February 2009 Paper

Combined adaptive optics: optical coherence tomography and adaptive optics: scanning laser ophthalmoscopy system for retinal imaging

Robert Zawadzki, Steven Jones, Diana Chen, Stacey Choi, Julia Evans, Scot Olivier, John Werner

Proceedings Volume 7163, 71630F (2009) https://doi.org/10.1117/12.809419

KEYWORDS: Optical coherence tomography, Scanning laser ophthalmoscopy, Adaptive optics optical coherence tomography, Adaptive optics, Imaging systems, Scanners, Eye, Retinal scanning, Data acquisition, Retina

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Proceedings Article | 14 July 2008 Paper

Gemini Planet Imager autonomous software

Jennifer Dunn, Robert Wooff, Malcolm Smith, Dan Kerley, Dave Palmer, Steve Jones, Jason Weiss, John Angione, James Graham

Proceedings Volume 7019, 701910 (2008) https://doi.org/10.1117/12.788032

KEYWORDS: Gemini Planet Imager, Gemini Observatory, Adaptive optics, Control systems, Coronagraphy, Iterated function systems, Computing systems, Human-machine interfaces, Observatories, Motion controllers

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Proceedings Article | 11 March 2008 Paper

Ultra-high resolution adaptive optics: optical coherence tomography for in vivo imaging of healthy and diseased retinal structures

Robert Zawadzki, Yan Zhang, Steven Jones, Stacey Choi, Barry Cense, Julia Evans, Donald Miller, Scot Olivier, John Werner

Proceedings Volume 6844, 684408 (2008) https://doi.org/10.1117/12.764115

KEYWORDS: Adaptive optics optical coherence tomography, Optical coherence tomography, Adaptive optics, Speckle, Image resolution, Visualization, Eye, Retina, Imaging systems, In vivo imaging

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Proceedings Article | 8 February 2008 Paper

Performance of a MEMS-based AO-OCT system

Julia Evans, Robert Zawadzki, Steve Jones, Samelia Okpodu, Scot Olivier, John Werner

Proceedings Volume 6888, 68880G (2008) https://doi.org/10.1117/12.771673

KEYWORDS: Wavefronts, Adaptive optics, Microelectromechanical systems, Error analysis, Eye, Adaptive optics optical coherence tomography, Eye models, Point spread functions, Deformable mirrors, Control systems

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Proceedings Article | 8 February 2008 Paper

Compact MEMS-based adaptive optics: optical coherence tomography for clinical use

Diana Chen, Scot Olivier, Steven Jones, Robert Zawadzki, Julia Evans, Stacey Choi, John Werner

Proceedings Volume 6888, 68880F (2008) https://doi.org/10.1117/12.772035

KEYWORDS: Adaptive optics, Mirrors, Adaptive optics optical coherence tomography, Monochromatic aberrations, Optical coherence tomography, Scanners, Deformable mirrors, Telescopes, Wavefront sensors, Eye

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Proceedings Article | 5 March 2007 Paper

Application of adaptive optics: optical coherence tomography for in vivo imaging of microscopic structures in the retina and optic nerve head

Robert Zawadzki, Yan Zhang, Steven Jones, Stacey Choi, Barry Cense, Diana Chen, Alfred Fuller, Donald Miller, Scot Olivier, John Werner

Proceedings Volume 6426, 64261O (2007) https://doi.org/10.1117/12.701512

KEYWORDS: Adaptive optics optical coherence tomography, Optical coherence tomography, Adaptive optics, Visualization, Retina, Eye, Deformable mirrors, In vivo imaging, Head, Wavefronts

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Proceedings Article | 5 March 2007 Paper

High-resolution adaptive optics scanning laser ophthalmoscope with dual deformable mirrors for large aberration correction

Diana Chen, Steven Jones, Dennis Silva, Scot Olivier

Proceedings Volume 6426, 64261L (2007) https://doi.org/10.1117/12.698728

KEYWORDS: Mirrors, Adaptive optics, Deformable mirrors, Microelectromechanical systems, Retina, Wavefront sensors, Scanning laser ophthalmoscopes, Telescopes, Eye, Aberration correction

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Proceedings Article | 5 March 2007 Paper

Volumetric imaging of inner retina with adaptive optics spectral-domain optical coherence tomography

Yan Zhang, Barry Cense, Ravi Jonnal, Weihua Gao, Steve Jones, Scot Olivier, Donald Miller

Proceedings Volume 6426, 64261P (2007) https://doi.org/10.1117/12.701960

KEYWORDS: Adaptive optics, Retina, Eye, Capillaries, Mirrors, Retinal scanning, Cameras, Cones, Nerve, Optical coherence tomography

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Adaptive optics (AO) coupled with ultra-fast spectral-domain optical coherence tomography (SD-OCT) has achieved the necessary 3D resolution, sensitivity, and speed for imaging the microscopic retina at the cellular level. While this technology has been rigorously applied to evaluating the 3D morphology of cone photoreceptors, similar detailed studies of cell-sized structures in the inner retina have yet to be undertaken. In this paper, we improve the technical performance of our AO ultrafast SD-OCT and investigate its use for imaging the microscopic inner retina, in particular the nerve fiber layer (NFL) and retinal capillary network. To maximize lateral resolution within the inner retina, focus was controlled with a high stroke, 37-actuator bimorph mirror (AOptix) that also served as the wavefront corrector of the AO. The AO system operated at a closed-loop rate of 25 Hz. The SD-OCT sub-system consisted of a superluminescent diode (&lgr;= 842 nm, &Dgr;&lgr;= 50 nm) and a 512 pixel line scan charge-coupled device (CCD) that acquired 72,000 A-scans/sec. Three different B-scan lengths (36, 60, and 120 A-scans/B-scan), which correspond to B-scan exposure durations of 0.5, 0.83, and 1.67 ms, were evaluated to determine the maximum B-scan length that could be tolerated without noticeable loss in image quality due to eye motion in the well fixated eye. Additional technical improvements included sub-pixel registration to remove instrument error and axial registration of the volume images. Small volume images were acquired at 2 and 7 degrees retinal eccentricity with focus systematically shifted through the retina. Small capillaries, some approaching the smallest in the human eye, were readily detected with AO SD-OCT. Appearance of the nerve fiber layer varied noticeably with depth. The most inner portion (presumably the inner limiting membrane) appeared as a thin irregular surface with little characteristic speckle noise. Within the NFL, complex striation patterns (presumably NFL bundles) were observed throughout the entire thickness with pattern density highest in the inner portion (~15 &mgr;m) and large corrugations (~35 &mgr;m) at the interface with the ganglion cell layer below. Speckle noise was significant throughout the NFL.

Proceedings Article | 9 February 2007 Paper

Ultrahigh-resolution adaptive optics - optical coherence tomography: toward isotropic 3-um resolution for in vivo retinal imaging

Robert Zawadzki, Yan Zhang, Steven Jones, R. Daniel Ferguson, Stacey Choi, Barry Cense, Julia Evans, Diana Chen, Donald Miller, Scot Olivier, John Werner

Proceedings Volume 6429, 642909 (2007) https://doi.org/10.1117/12.704639

KEYWORDS: Adaptive optics, Adaptive optics optical coherence tomography, Optical coherence tomography, Eye, Light sources, Wavefronts, Image resolution, Chromatic aberrations, Retina, Imaging systems

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Proceedings Article | 9 February 2007 Paper

Adaptive optics ophthalmologic systems using dual deformable mirrors

S. Jones, S. Olivier, D. Chen, S. Joeres, S. Sadda, R. Zawadzki, J. Werner, D. Miller

Proceedings Volume 6467, 64670H (2007) https://doi.org/10.1117/12.711189

KEYWORDS: Adaptive optics, Eye, Deformable mirrors, Mirrors, Imaging systems, Retina, Wavefronts, Microelectromechanical systems, Optical coherence tomography, Actuators

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Proceedings Article | 7 March 2006 Paper

Motion-free volumetric retinal imaging with adaptive optics spectral-domain optical coherence tomography

Yan Zhang, Jungtae Rha, Abraham Cense, Ravi Jonnal, Weihua Gao, Robert Zawadzki, John Werner, Steve Jones, Scot Olivier, Donald Miller

Proceedings Volume 6138, 613802 (2006) https://doi.org/10.1117/12.649006

KEYWORDS: Adaptive optics, Eye, Retina, Mirrors, Cameras, Optical coherence tomography, Cones, Retinal scanning, Adaptive optics optical coherence tomography, Distortion

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Proceedings Article | 7 March 2006 Paper

Adaptive optics-optical coherence tomography for in vivo retinal imaging: effects of spectral bandwidth on image quality

Robert Zawadzki, Steven Jones, Mingtao Zhao, Stacey Choi, Sophie Laut, Scot Olivier, Joseph Izatt, John Werner

Proceedings Volume 6138, 61381X (2006) https://doi.org/10.1117/12.647540

KEYWORDS: Optical coherence tomography, Adaptive optics, Adaptive optics optical coherence tomography, Wavefronts, Light sources, Eye, Mirrors, Wavefront sensors, Retinal scanning, Deformable mirrors

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Proceedings Article | 20 February 2006 Paper

Adaptive optics/optical coherence tomography for in vivo retinal imaging: comparative analysis of two wavefront correctors

Robert Zawadzki, Steven Jones, Mingtao Zhao, Stacey Choi, Sophie Laut, Scot Olivier, Joseph Izatt, John Werner

Proceedings Volume 6079, 607908 (2006) https://doi.org/10.1117/12.647568

KEYWORDS: Adaptive optics, Wavefronts, Mirrors, Optical coherence tomography, Adaptive optics optical coherence tomography, Deformable mirrors, Eye, Microelectromechanical systems, Wavefront sensors, Retinal scanning

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Proceedings Article | 12 November 2005 Paper

Bimorph deformable mirror: an appropriate wavefront corrector for retinal imaging?

Sophie Laut, Steve Jones, Hyunkyu Park, David Horsley, Scot Olivier, John Werner

Proceedings Volume 6007, 60070Q (2005) https://doi.org/10.1117/12.630961

KEYWORDS: Wavefronts, Monochromatic aberrations, Adaptive optics, Actuators, Deformable mirrors, Wavefront sensors, Lenses, Mirrors, Retinal scanning, Control systems

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Proceedings Article | 11 November 2005 Paper

Scanning laser ophthalmoscope design with adaptive optics

Sophie Laut, Steven Jones, Scot Olivier, John Werner

Proceedings Volume 6007, 60070I (2005) https://doi.org/10.1117/12.630975

KEYWORDS: Eye, Retina, Adaptive optics, Scanning laser ophthalmoscopy, Wavefronts, Light emitting diodes, Imaging systems, Actuators, Wavefront sensors, Mirrors

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Proceedings Article | 7 October 2005 Paper

Adaptive-optics optical coherence tomography for high-resolution and high-speed in vivo retinal imaging

Robert Zawadzki, Stacey Choi, Sophie Laut, John Werner, Steven Jones, Scot Olivier, Mingtao Zhao, Bradley Bower, Joseph Izatt

Proceedings Volume 5861, 586104 (2005) https://doi.org/10.1117/12.632962

KEYWORDS: Optical coherence tomography, Adaptive optics, Eye, Adaptive optics optical coherence tomography, Imaging systems, In vivo imaging, Retinal scanning, Image resolution, Deformable mirrors, Retina

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Proceedings Article | 24 December 2003 Paper

Characterization and operation of a liquid crystal adaptive optics phoropter

Abdul Ahad Awwal, Brian Bauman, Donald Gavel, Scot Olivier, Steve Jones, Dennis Silva, Joseph Hardy, Thomas Barnes, John Werner

Proceedings Volume 5169, (2003) https://doi.org/10.1117/12.510393

KEYWORDS: Wavefronts, Spatial light modulators, Adaptive optics, Eye, Liquid crystals, Sensors, Wavefront sensors, Visualization, Retina, Monochromatic aberrations

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Proceedings Article | 19 November 2003 Paper

Extreme adaptive optics planet imager: XAOPI

Bruce Macintosh, James Graham, Lisa Poyneer, Gary Sommargren, Julia Wilhelmsen, Don Gavel, Steve Jones, Paul Kalas, James Lloyd, Russ Makidon, Scot Olivier, Dave Palmer, Jennifer Patience, Marshall Perrin, Scott Severson, Andrew Sheinis, Anand Sivaramakrishnan, Mitch Troy, J. Wallace

Proceedings Volume 5170, (2003) https://doi.org/10.1117/12.506836

KEYWORDS: Wavefronts, Adaptive optics, Wavefront sensors, Planets, Imaging systems, Coronagraphy, Point spread functions, Stars, Telescopes, Mirrors

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