Dr. Sunil Dehipawala Profile

Dr. Sunil Dehipawala

Associate professor at Queensborough Community College

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Publications (23)

Proceedings Article | 14 September 2018 Open Access

Assessment of high-school engineering education outreach program employing project-based learning in astronomy and bio-optics within a college setting

Sunil Dehipawala, Regina Sullivan, Raul Armendariz, Vazgen Shekoyan, George Tremberger, David Lieberman, Tak Cheung

Proceedings Volume 10741, 107410H (2018) https://doi.org/10.1117/12.2320683

KEYWORDS: Muons, Sensors, Cancer, Outreach programs, Scintillation, Engineering education, Physics, Fractal analysis, Astronomy, Magnetism

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Proceedings Article | 7 September 2018 Paper

Comparison of structural properties of iron nano-particles prepared by sol-gel method and spin coating technique

Sunil Dehipawala, Pubudu Samarasekara, Khushpreet Kaur, Harsha Rajapakse

Proceedings Volume 10731, 107310T (2018) https://doi.org/10.1117/12.2320410

KEYWORDS: Iron, Absorption, Coating, X-rays, Sol-gels, Thin films, Chemical species, Oxides, Thin film coatings, Oxidation

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Proceedings Article | 11 September 2015 Paper

Bioinformatics comparison of sulfate-reducing metabolism nucleotide sequences

G. Tremberger, Sunil Dehipawala, A. Nguyen, E. Cheung, R. Sullivan, T. Holden, D. Lieberman, T. Cheung

Proceedings Volume 9606, 960610 (2015) https://doi.org/10.1117/12.2188390

KEYWORDS: Fractal analysis, Bacteria, Sulfur, Mode conditioning cables, Thermodynamics, Bioinformatics, Proteins, Calibration, Biological research, Cadmium sulfide

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Proceedings Article | 11 September 2015 Paper

Complexity of genetic sequences modified by horizontal gene transfer and degraded-DNA uptake

George Tremberger, S. Dehipawala, A. Nguyen, E. Cheung, R. Sullivan, T. Holden, D. Lieberman, T. Cheung

Proceedings Volume 9606, 96060H (2015) https://doi.org/10.1117/12.2186550

KEYWORDS: Fractal analysis, Microorganisms, Toxicity, Proteins, Genetics, Transform theory, Calibration, Cadmium sulfide, Iron, Resistance

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Proceedings Article | 11 September 2015 Paper

The bioinformatics of nucleotide sequence coding for proteins requiring metal coenzymes and proteins embedded with metals

G. Tremberger, Sunil Dehipawala, E. Cheung, T. Holden, R. Sullivan, A. Nguyen, D. Lieberman, T. Cheung

Proceedings Volume 9606, 96060E (2015) https://doi.org/10.1117/12.2186563

KEYWORDS: Fractal analysis, Metals, Mode conditioning cables, Proteins, Bioinformatics, Switches, Zinc, Clocks, Biological research, Iron

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All metallo-proteins need post-translation metal incorporation. In fact, the isotope ratio of Fe, Cu, and Zn in physiology and oncology have emerged as an important tool. The nickel containing F430 is the prosthetic group of the enzyme methyl coenzyme M reductase which catalyzes the release of methane in the final step of methano-genesis, a prime energy metabolism candidate for life exploration space mission in the solar system. The 3.5 Gyr early life sulfite reductase as a life switch energy metabolism had Fe-Mo clusters. The nitrogenase for nitrogen fixation 3 billion years ago had Mo. The early life arsenite oxidase needed for anoxygenic photosynthesis energy metabolism 2.8 billion years ago had Mo and Fe. The selection pressure in metal incorporation inside a protein would be quantifiable in terms of the related nucleotide sequence complexity with fractal dimension and entropy values. Simulation model showed that the studied metal-required energy metabolism sequences had at least ten times more selection pressure relatively in comparison to the horizontal transferred sequences in Mealybug, guided by the outcome histogram of the correlation R-sq values. The metal energy metabolism sequence group was compared to the circadian clock KaiC sequence group using magnesium atomic level bond shifting mechanism in the protein, and the simulation model would suggest a much higher selection pressure for the energy life switch sequence group. The possibility of using Kepler 444 as an example of ancient life in Galaxy with the associated exoplanets has been proposed and is further discussed in this report. Examples of arsenic metal bonding shift probed by Synchrotron-based X-ray spectroscopy data and Zn controlled FOXP2 regulated pathways in human and chimp brain studied tissue samples are studied in relationship to the sequence bioinformatics. The analysis results suggest that relatively large metal bonding shift amount is associated with low probability correlation R-sq outcome in the bioinformatics simulation.

Proceedings Article | 20 August 2015 Presentation + Paper

Characterization of nano-sized iron particle layers spin coated on glass substrate

Sunil Dehipawala, Pubudu Samarasekara, Rasika Dahanayake, George Tremberger, Tak Cheung, Harry Gafney

Proceedings Volume 9549, 95490X (2015) https://doi.org/10.1117/12.2187314

KEYWORDS: Iron, Absorption, X-rays, Particles, Thin films, Chemical species, Ions, Glasses, Coating, Oxides

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Proceedings Article | 26 September 2013 Paper

Assessing fluctuating evolutionary pressure in yeast and mammal evolutionary rate covariation using bioinformatics of meiotic protein genetic sequences

Sunil Dehipawala, A. Nguyen, G. Tremberger, E. Cheung, T. Holden, D. Lieberman, T. Cheung

Proceedings Volume 8865, 88650H (2013) https://doi.org/10.1117/12.2024633

KEYWORDS: Fractal analysis, Yeast, Proteins, Astrobiology, Bioinformatics, Medical research, Genetics, Biomedical optics, Analytical research, Image information entropy

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The evolutionary rate co-variation in meiotic proteins has been reported for yeast and mammal using phylogenic branch lengths which assess retention, duplication and mutation. The bioinformatics of the corresponding DNA sequences could be classified as a diagram of fractal dimension and Shannon entropy. Results from biomedical gene research provide examples on the diagram methodology. The identification of adaptive selection using entropy marker and functional-structural diversity using fractal dimension would support a regression analysis where the coefficient of determination would serve as evolutionary pathway marker for DNA sequences and be an important component in the astrobiology community. Comparisons between biomedical genes such as EEF2 (elongation factor 2 human, mouse, etc), WDR85 in epigenetics, HAR1 in human specificity, clinical trial targeted cancer gene CD47, SIRT6 in spermatogenesis, and HLA-C in mosquito bite immunology demonstrate the diagram classification methodology. Comparisons to the SEPT4-XIAP pair in stem cell apoptosis, testesexpressed taste genes TAS1R3-GNAT3 pair, and amyloid beta APLP1-APLP2 pair with the yeast-mammal DNA sequences for meiotic proteins RAD50-MRE11 pair and NCAPD2-ICK pair have accounted for the observed fluctuating evolutionary pressure systematically. Regression with high R-sq values or a triangular-like cluster pattern for concordant pairs in co-variation among the studied species could serve as evidences for the possible location of common ancestors in the entropy-fractal dimension diagram, consistent with an example of the human-chimp common ancestor study using the FOXP2 regulated genes reported in human fetal brain study. The Deinococcus radiodurans R1 Rad-A could be viewed as an outlier in the RAD50 diagram and also in the free energy versus fractal dimension regression Cook’s distance, consistent with a non-Earth source for this radiation resistant bacterium. Convergent and divergent fluctuating evolutionary pressure could be studied with extension to genetic sequences in organisms in possible astrobiology conditions, with the assumption that the continuation of a book of life would require meiotic proteins everywhere in the universe.

Proceedings Article | 26 September 2013 Paper

Elongation Factor-Tu (EF-Tu) proteins structural stability and bioinformatics in ancestral gene reconstruction

Sunil Dehipawala, A. Nguyen, G. Tremberger, E. Cheung, P. Schneider, D. Lieberman, T. Holden, T. Cheung

Proceedings Volume 8865, 88650G (2013) https://doi.org/10.1117/12.2024627

KEYWORDS: Fractal analysis, Proteins, Computer simulations, Astrobiology, Calibration, Dichroic materials, Biomedical optics, Bioinformatics, Analytical research, Image information entropy

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A paleo-experimental evolution report on elongation factor EF-Tu structural stability results has provided an opportunity to rewind the tape of life using the ancestral protein sequence reconstruction modeling approach; consistent with the book of life dogma in current biology and being an important component in the astrobiology community. Fractal dimension via the Higuchi fractal method and Shannon entropy of the DNA sequence classification could be used in a diagram that serves as a simple summary. Results from biomedical gene research provide examples on the diagram methodology. Comparisons between biomedical genes such as EEF2 (elongation factor 2 human, mouse, etc), WDR85 in epigenetics, HAR1 in human specificity, DLG1 in cognitive skill, and HLA-C in mosquito bite immunology with EF Tu DNA sequences have accounted for the reported circular dichroism thermo-stability data systematically; the results also infer a relatively less volatility geologic time period from 2 to 3 Gyr from adaptation viewpoint. Comparison to Thermotoga maritima MSB8 and Psychrobacter shows that Thermus thermophilus HB8 EF-Tu calibration sequence could be an outlier, consistent with free energy calculation by NUPACK. Diagram methodology allows computer simulation studies and HAR1 shows about 0.5% probability from chimp to human in terms of diagram location, and SNP simulation results such as amoebic meningoencephalitis NAF1 suggest correlation. Extensions to the studies of the translation and transcription elongation factor sequences in Megavirus Chiliensis, Megavirus Lba and Pandoravirus show that the studied Pandoravirus sequence could be an outlier with the highest fractal dimension and lowest entropy, as compared to chicken as a deviant in the DNMT3A DNA methylation gene sequences from zebrafish to human and to the less than one percent probability in computer simulation using the HAR1 0.5% probability as reference. The diagram methodology would be useful in ancestral gene reconstruction studies in astrobiology and also be applicable to the study of point mutation in conformational thermostabilization research with Synchrotron based X-ray data for drug applications such as Parkinson’s disease.

Proceedings Article | 24 October 2012 Paper

Remote sensing of ash tree health associated with the emerald ash borer via analyses of fluctuations in land-based and satellite-based data indices

George Tremberger, Sunil Dehipawala, Todd Holden, Paul Marchese, Tak Cheung

Proceedings Volume 8513, 851304 (2012) https://doi.org/10.1117/12.929786

KEYWORDS: Fractal analysis, MODIS, Calibration, Remote sensing, Satellites, Data modeling, Statistical analysis, Biological research, Vegetation, Satellite communications

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Proceedings Article | 15 October 2012 Paper

Utilization of Solar Dynamics Observatory space weather digital image data for comparative analysis with application to Baryon Oscillation Spectroscopic Survey

V. Shekoyan, S. Dehipawala, Ernest Liu, Vivek Tulsee, R. Armendariz, G. Tremberger, T. Holden, P. Marchese, T. Cheung

Proceedings Volume 8499, 84991Y (2012) https://doi.org/10.1117/12.929747

KEYWORDS: Fractal analysis, Solar energy, Statistical analysis, Calibration, Magnetism, Observatories, Spectroscopy, Digital imaging, Analytical research, Imaging spectroscopy

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Proceedings Article | 15 October 2012 Paper

Kepler mission exoplanet transit data analysis using fractal imaging

S. Dehipawala, G. Tremberger, Y. Majid, T. Holden, D. Lieberman, T. Cheung

Proceedings Volume 8500, 85000T (2012) https://doi.org/10.1117/12.930004

KEYWORDS: Fractal analysis, Exoplanets, Image compression, Stars, Image analysis, Fourier transforms, Space telescopes, Telescopes, Image resolution, Data analysis

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Proceedings Article | 15 October 2012 Paper

Nucleotide fluctuation in extremophilic cold-adapted sequences and their degradation codes

George Tremberger, S. Dehipawala, E. Cheung, Jesaiah Prayor, Rafael Duran, P. Schneider, D. Lieberman, T. Holden, T. Cheung

Proceedings Volume 8521, 85210J (2012) https://doi.org/10.1117/12.929653

KEYWORDS: Fractal analysis, Image information entropy, Data modeling, Bioinformatics, Calibration, Biological research, Astrobiology, Factor analysis, Mode conditioning cables, Atomic layer deposition

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Proceedings Article | 10 March 2012 Paper

Effect of non-homogenous thermal stress during sub-lethal photodynamic antimicrobial chemotherapy

N. Gadura, D. Kokkinos, S. Dehipawala, E. Cheung, R. Sullivan, R. Subramaniam, P. Schneider, G. Tremberger, T. Holden, D. Lieberman, T. Cheung

Proceedings Volume 8211, 82110O (2012) https://doi.org/10.1117/12.909486

KEYWORDS: Fractal analysis, Light sources, Photoacoustic tomography, Thermal effects, Photodynamic therapy, Pathogens, Microscopy, Iron, Oxides, Doping

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Proceedings Article | 23 February 2012 Paper

Optical diffusion property of cerumen from ear canal and correlation to metal content measured by synchrotron x-ray absorption

Todd Holden, Sumudu Dehipawala, E. Cheung, U. Golebiewska, P. Schneider, G. Tremberger, D. Kokkinos, D. Lieberman, Sunil Dehipawala, T. Cheung

Proceedings Volume 8221, 82211L (2012) https://doi.org/10.1117/12.909896

KEYWORDS: Metals, Absorption, Synchrotrons, Pathogens, Microorganisms, Diffusion, Zinc, Ear, Near field optics, Light sources

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Proceedings Article | 9 February 2012 Paper

Optical speckles of blood proteins embedded in porous glassy substrate

T. Holden, S. Dehipawala, D. Kokkinos, A. Berisha, E. Cheung, A. Nguyen, U. Golebiewska, P. Schneider, G. Tremberger, D. Lieberman, T. Cheung

Proceedings Volume 8222, 822207 (2012) https://doi.org/10.1117/12.909503

KEYWORDS: Proteins, Blood, Molecules, Speckle, Speckle pattern, Calibration, Iron, Doping, Diffusion, Molecular interactions

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Proceedings Article | 2 February 2012 Paper

Single mode and sub-cellular fiber probes for cell scattering and density variation measurements

D. Kokkinos, T. Holden, S. Dehipawala, L. Mora, W. Huazhco, N. Gadura, U. Golebiewska, P. Schneider, G. Tremberger, D. Lieberman, T. Cheung

Proceedings Volume 8230, 82301G (2012) https://doi.org/10.1117/12.909911

KEYWORDS: Scattering, Fourier transforms, Refractive index, Single mode fibers, Monte Carlo methods, Correlation function, Microscopy, Yeast, Calibration, Optical testing

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Proceedings Article | 30 January 2012 Paper

Fiber optic based heart-rate and pulse pressure shape monitor

D. Kokkinos, S. Dehipawala, T. Holden, E. Cheung, M. Musa, G. Tremberger, P. Schneider, D. Lieberman, T. Cheung

Proceedings Volume 8218, 82180V (2012) https://doi.org/10.1117/12.909582

KEYWORDS: Fiber optics sensors, Sensors, Electrocardiography, Fractal analysis, Heart, Fiber optics, Arteries, Single mode fibers, Optical fabrication, Photonic crystal fibers

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Proceedings Article | 23 September 2011 Paper

Diverse nucleotide compositions and sequence fluctuation in Rubisco protein genes

Todd Holden, S. Dehipawala, E. Cheung, R. Bienaime, J. Ye, G. Tremberger, P. Schneider, D. Lieberman, T. Cheung

Proceedings Volume 8152, 81520S (2011) https://doi.org/10.1117/12.893434

KEYWORDS: Fractal analysis, Proteins, Microorganisms, Image information entropy, Sulfur, Biology, Photosynthesis, Metals, Mars, Biological research

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Proceedings Article | 23 September 2011 Paper

Technologically important extremophile 16S rRNA sequence Shannon entropy and fractal property comparison with long term dormant microbes

Todd Holden, N. Gadura, S. Dehipawala, E. Cheung, M. Tuffour, P. Schneider, G. Tremberger, D. Lieberman, T. Cheung

Proceedings Volume 8152, 81520T (2011) https://doi.org/10.1117/12.893450

KEYWORDS: Fractal analysis, Microorganisms, Image information entropy, Biology, Uranium, Proteins, Rockets, Statistical analysis, Electrodes, Data modeling

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Proceedings Article | 16 September 2011 Paper

Remote sensing of LAI-FPAR fluctuations and Synchrotron EXAFS-XANES studies of metal absorption under stress

T. Holden, S. Dehipawala, E. Cheung, R. Regan, G. Tremberger, U. Golebiewska, P. Marchese, T. Cheung

Proceedings Volume 8156, 81560O (2011) https://doi.org/10.1117/12.893887

KEYWORDS: Fractal analysis, Absorption, Remote sensing, Synchrotrons, Metals, Zinc, Iron, MODIS, Calibration, Environmental sensing

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Proceedings Article | 7 September 2010 Paper

Cyanobacteria gene and protein sequences in diurnal oscillation metabolic processes

George Tremberger, T. Holden, E. Cheung, S. Dehipawala, N. Gadura, U. Golebiewska, K. Valentin, M. Smulczeski, W. Satizabal, P. Schneider, D. Lieberman, T. Cheung

Proceedings Volume 7819, 78190U (2010) https://doi.org/10.1117/12.860093

KEYWORDS: Fractal analysis, Proteins, Iron, Biology, Photosynthesis, Organisms, Image information entropy, Nitrogen, Astrobiology, Oxygen

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Proceedings Article | 7 September 2010 Paper

Zn-metalloprotease sequences in extremophiles

T. Holden, S. Dehipawala, U. Golebiewska, E. Cheung, G. Tremberger, E. Williams, P. Schneider, N. Gadura, D. Lieberman, T. Cheung

Proceedings Volume 7819, 78190V (2010) https://doi.org/10.1117/12.860091

KEYWORDS: Fractal analysis, Proteins, Organisms, Zinc, Biology, Image information entropy, Calibration, Chemical species, Cadmium sulfide, Astrobiology

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Proceedings Article | 19 August 2009 Paper

Deep-water chlorophyll concentration global time series fluctuation

T. Holden, D. Sunil, E. Cheung, D. Cotten, D. Klarberg, G. Tremberger, T. Nasar, J. Taylor, P. Marchese, T. Cheung

Proceedings Volume 7459, 74590O (2009) https://doi.org/10.1117/12.825807

KEYWORDS: Fractal analysis, Calibration, Wind energy, Satellites, Computer simulations, Climatology, Satellite imaging, Data modeling, Autoregressive models, Remote sensing

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Showing 5 of 23 publications

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