We present a turn-key portable picosecond fiber laser for efficient quantum dot excitation to generate single photons. The laser combines a mode-hop-free tunability in the regions 770-980 nm and 1150-1500 nm with a high pulse-to-pulse coherence of 98%. A high single photon purity and indistinguishability were demonstrated. An excellent long-term power stability with a standard deviation of less than 0.3% and wavelength stability of better than 5 pm were achieved. The laser enables excitation of different semiconductor quantum dots and excitation schemes, essential for versatile easy-to-use single-photon sources based on quantum dots for research applications and commercial quantum computing.
We present a fully integrated, clinical-compatible SRS imaging device giving access to the complete Raman spectrum during tumor surgeries. Leveraging the advantages of a compact and robust fiber laser, we have integrated the entire microscopy system into a clinical cart, facilitating deployment in diverse clinical environments. The laser provides rapid tunability within milliseconds across a broad spectral range of 700 to 3300 cm^-1, covering biomedically relevant resonances in the fingerprint region. For detailed examination of larger tissue samples, we have designed a high-speed, low-resolution imaging mode to quickly identify cancerous hot-spots, followed by a high-resolution imaging mode.
Hyperspectral Stimulated Raman Imaging (SRS) has shown great promise as a label-free chemical imaging technique in biomedical and medical research. We present recent developments in SRS integrating a compact and portable all-fiber laser with balanced detection into an imaging system, aiming to enhance ease-of-use, specificity, and reliability in acquiring high-speed, multicolor chemical images. The system's adaptability is highlighted by integrating the entire microscopy system into a clinical cart, ensuring clinical compatibility as well as its seamless integration with a Nikon Eclipse Ti widefield microscope, providing a compact and robust extension for varied imaging setups. The system incorporates a balanced detector to enable shot-noise-limited measurements, accommodating over 100mW of Stokes power on the detector.
We present a turn-key portable picosecond fiber laser for efficient quantum dot excitation to generate single photons. The laser combines a mode-hop-free tunability in the regions 770-980 nm and 1150-1500 nm with a high pulse-to-pulse coherence of 98%. A high single photon purity and indistinguishability were demonstrated. An excellent long-term power stability with a standard deviation of less than 0.3% and wavelength stability of better than 5 pm were achieved. The laser enables excitation of different semiconductor quantum dots and excitation schemes, essential for versatile easy-to-use single-photon sources based on quantum dots for research applications and commercial quantum computing.
We present a fully integrated, clinical-compatible SRS imaging device giving access to the complete Raman spectrum during tumor surgeries. Leveraging the advantages of a compact and robust fiber laser, we have integrated the entire microscopy system into a clinical cart, facilitating deployment in diverse clinical environments. The laser provides rapid tunability within milliseconds across a broad spectral range of 700 to 3300 cm^-1, covering biomedically relevant resonances in the fingerprint region. For detailed examination of larger tissue samples, we have designed a high-speed, low-resolution imaging mode to quickly identify cancerous hot-spots, followed by a high-resolution imaging mode.
Hyperspectral Stimulated Raman Imaging (SRS) has shown great promise as a label-free chemical imaging technique in biomedical and medical research. We present recent developments in SRS integrating a compact and portable all-fiber laser with balanced detection into an imaging system, aiming to enhance ease-of-use, specificity, and reliability in acquiring high-speed, multicolor chemical images. The system's adaptability is highlighted by its seamless integration with a Nikon Eclipse Ti widefield microscope, providing a compact and robust extension for varied imaging setups. The system incorporates a balanced detector to enable shot-noise-limited measurements, accommodating over 100mW of Stokes power on the detector.
We present a fully integrated, clinical-compatible SRS imaging device giving access to the complete Raman spectrum during tumor surgeries. For detailed examination of larger tissue samples, we have designed a high-speed, low-resolution imaging mode to quickly identify cancerous hot-spots, followed by a high-resolution imaging mode. Leveraging the advantages of a compact and robust fiber laser, we have integrated the entire microscopy system into a clinical cart, facilitating deployment in diverse clinical environments. The laser provides rapid tunability within milliseconds across a broad spectral range of 700 to 3300 1/cm, covering biomedically relevant resonances in the fingerprint region.
We present our recent developments in utilizing a compact and portable light source for high-speed multicolor stimulated Raman scattering imaging (SRS) in biomedical and medical environments. The source combines a rapid and wide tunability for accessing Raman bands between 700 and 3300 cm-1 with high stability in terms of power (deviation < 0.3 %) and wavelength (deviation < 0.5 pm) over more than 100 h. We were able to shorten the Stokes pulse duration to below 3ps, resulting in a twofold increase in SRS signal intensity compared to our previous version (7ps).
We present our recent developments in utilizing a compact and portable light source for high-speed multicolor stimulated Raman scattering imaging (SRS) in biomedical and medical environments. The source combines a rapid and wide tunability for accessing Raman bands between 700 and 3300 cm-1 with high stability in terms of power (deviation < 0.3 %) and wavelength (deviation < 0.5 pm) over more than 100 h. We were able to shorten the Stokes pulse duration to below 3ps, resulting in a twofold increase in SRS signal intensity compared to our previous version (7ps).
We present a novel turn-key portable fiber laser for efficient quantum dot excitation to generate single photons. The laser combines a mode-hop-free and alignment-free tunability between 770 nm to 980 nm with a high pulse-to-pulse coherence of 98%. Second order correlation measurements demonstrate a high single photon purity. The laser shows long-term power stability with a standard deviation of less than 0.3% and wavelength stability of better than 5 pm. This development constitutes an essential step for advancing single-photon sources based on quantum dots in terms of integrability and ease of use for research applications and commercial quantum computing.
We present our recent developments in utilizing a compact and portable light source for high-speed multicolor stimulated Raman scattering imaging (SRS) in biomedical and medical environments. The source combines a rapid and wide tunability for accessing Raman bands between 700 and 3300 cm-1 with high stability in terms of power (deviation < 0.3 %) and wavelength (deviation < 0.5 pm) over more than 100 h. We highlight applications in metabolic cell imaging and the identification of pharmaceuticals in complex environments such as skin by harvesting contrast from several Raman bands.
We present recent developments on our portable light source for multicolor coherent Raman imaging. The source combines a rapid and wide tunability for accessing Raman bands between 700 and 3200 cm-1 with high stability for long term measurements utilizing software PID-stabilization by means of an integrated optical miniature spectrometer. We present a long-term power stability with a standard deviation of less than 0.3% and a wavelength stability of better than 5pm over the course of 100h. This development constitutes an important step for advancing CRI microscopy in terms of portability and stability for applications in medical diagnostics or environmental sensing.
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