KEYWORDS: Optical coherence tomography, Arteries, Veins, Visualization, Skin, Ear, 3D image processing, Tissues, 3D image reconstruction, In vivo imaging
The degree and variants of structural changes in the vessels of the skin are important pathomorphological signs of the degree of tissue damage and potential possibilities and the course of its regeneration in various skin injuries, including burns. Objective: to identify arteries and veins with 3D optical coherence tomography during the experiment, describing their distinctive features. Materials and methods. To identify the vessels on OCT images of the skin, the rabbit ear was examined in vivo over the superficially located central artery and marginal vein and the vascular-free zone with a needle mark in the lumen of the vessel. Histo-tomographic comparisons were performed. Result. OCT signs of arterial and venous vessels are formulated.
Some pathological conditions accompanied by dynamic monitoring of the state of the pleura and subpleural lung tissue. For the most accurate diagnosis and selection of an adequate method of treatment, it is necessary to assess the morphofunctional state of the pleura and subpleural tissue, as well as monitoring the effectiveness of therapeutic and preventive measures, which necessitates intravital methods of their visualization. In case of hydro- and / or pneumothorax, the addition of puncture and drainage of the pleural cavity with optical coherence tomography of the pleura and subpleural lung tissue without lung injury makes it possible to diagnose thickening of the visceral pleura; cellularity is disturbed or absent, roundness or flattening of the shape of the alveolar cavities is revealed, up to the complete absence of visible alveolar cavities, the heterogeneity of their contents, the thickening of the interalveolar septa is determined initially and during treatment.
Tattooing and permanent makeup are very popular [1]. Nowadays there is practically no information about the effect of artificial pigment on the surrounding tissues. The issue of removing artificial pigment, the selection of individual parameters of laser radiation, depending on the level of occurrence of the pigment and individual characteristics of the skin, and control of the effectiveness of the procedure is also no less urgent. Optical coherence tomography (OCT) is a promising method for noninvasive examination of the skin, which allows one to assess its structure and morphological changes occurring in it in real time [2,3]. The purpose of this work is to assess the condition of the skin containing artificial pigment before and after laser tattoo removal using the method of optical coherence tomography (OCT).
Many skin and systemic diseases are accompanied by changes in the vessels of the skin. The role of the vascular component in the pathogenesis of diseases in most cases remains underestimated and is not sufficiently taken into account in the treatment. One of the reasons is the lack of safe, effective and accessible methods of objective assessment of skin vessels. The possibilities of the histological method are limited [1] due to vascular damage during biopsy and manufacture of the drug, as well as the inability to perform multi-focal and dynamic studies. Capillaroscopy and dermatoscopy also do not solve the problem, as they allow only indirectly to judge the condition of the skin vessels [2]. The possibilities of other non-invasive methods of examining skin vessels are being studied. One of the promising methods of lifetime examination of skin vessels is optical coherence tomography (OCT). This is a high-resolution (10-20 mk) method for visualizing the structure of biological tissues, using low-intensity near-infrared light as probing radiation [3]. The purpose of the work To study the possibilities of using OCT and 3D OCT to assess the state of the microcirculatory bed of the skin.
KEYWORDS: Tumors, Tissues, Skin, Algorithm development, 3D image processing, Angiography, 3D image reconstruction, Optoacoustics, Reconstruction algorithms, In vivo imaging
We demonstrate the opportunities of the developed 3D optoacoustic image processing algorithm to characterize numerically the vasculature parameters in different applications including monitoring of tumor angiogenesis and assessing skin aging.
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