Coarse-scale Optoretinography (CoORG) is an ORG approach that enables quick (10min), extended-field (5 deg) assessment of retinal structure and function. This study explores the feasibility of CoORG in discerning early and sensitive changes in retinitis pigmentosa (RP). In general, diminished cone function is observed in RP compared to normals using CoORG, even in areas of normal apparent outer retinal structure. This underscores the potential of CoORG for early & sensitive detection of retinal dysfunction in diseases such as RP and AMD.
Optoretinography serves as an effective biomarker for light-evoked retinal activity owing to its sensitive, objective, and precise localization of retinal function and dysfunction. We developed a coarse-scale optoretinography instrument based on a line-scan spectral domain OCT. We demonstrate its ability to acquire robust and repeatable ORG signals rapidly over a 5° field of view in a single acquisition, without adaptive optics. The high repeatability, good agreement with cellular-scale ORGs, and non-AO operation are of promise for its widespread clinical application to retinal diseases such as AMD and inherited retinal degenerations.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.