The use of functional magnetic resonance imaging (fMRI) to measure functional connectivity among brain areas has the
potential to identify neural networks associated with particular cognitive processes. However, fMRI signals are not a
direct measure of neural activity but rather represent blood oxygenation level-dependent (BOLD) signals. Correlated
BOLD signals between two brain regions are therefore a combination of neural, neurovascular, and vascular coupling.
Here, we describe a procedure for isolating brain functional connectivity associated with a specific cognitive process.
Coherency magnitude (measuring the strength of coupling between two time series) and phase (measuring the temporal
latency differences between two time series) are computed during performance of a particular cognitive task and also for
a control condition. Subtraction of the coherency magnitude and phase differences for the two conditions removes
sources of correlated BOLD signals that do not modulate as a function of cognitive task, resulting in a more direct
measure of functional connectivity associated with changes in neuronal activity. We present two applications of this task
subtraction procedure, one to measure changes in strength of coupling associated with sustained visual spatial attention,
and one to measure changes in temporal latencies between brain areas associated with voluntary visual spatial attention.
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