Ms. Valeria Belikova Profile

Valeria Belikova

at Samara State Technical Univ

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Publications (5)

Proceedings Article | 1 April 2020 Presentation

Fiber photonics solutions for tissue analysis for fast biomedical diagnostics (Conference Presentation)

Olga Bibikova, Alena Sergeeva, Stanislav Perevoschikov, Raushania Gaynullina, Iskander Usenov, Valeria Belikova, Anastasya Melenteva, Alexey Bocharnikov, Tatiana Sakharova, Evgeny Shirshin, Alexander Tonevitsky, Viacheslav Artyushenko

Proceedings Volume 11359, 113590D (2020) https://doi.org/10.1117/12.2555420

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Proceedings Article | 9 March 2020 Presentation

Mid-infrared fiber spectroscopy for detection of cartilage degeneration in osteoarthritis (Conference Presentation)

Olga Bibikova, Valentin Mironovich, Iskander Usenov, Elena Feliksberger, Alexey Bocharnikov, Anastasia Surkova, Valeria Belikova, Ervin Nippolainen, Isaac Afara, Julian Haas, Vesa Virtanen, Lassi Rieppo, Harold Brommer, René van Weeren, Michael Pleyer, Johannes Koeth, Markus Nägele, Juha Töyräs, Boris Mizaikoff, Tatiana Sakharova, Viacheslav Artyushenko

Proceedings Volume 11233, 112330J (2020) https://doi.org/10.1117/12.2544893

KEYWORDS: Spectroscopy, Cartilage, Mid-IR, Quantum cascade lasers, FT-IR spectroscopy, Tissues, Molecules, Molecular spectroscopy, Fiber optics, Diagnostics

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Proceedings Article | 22 July 2019 Paper

Clinical spectroscopy for biotissues and bioliquids

Olga Bibikova, Anastasya Melenteva, Valeria Belikova, Urszula Zabarylo, Thaddäus Hocotz, Iskander Usenov, Elena Feliksberger, Tatiana Sakharova, Georgy Danielyan, Olaf Minet, Viacheslav Artyushenko

Proceedings Volume 11079, 110790I (2019) https://doi.org/10.1117/12.2526586

KEYWORDS: Spectroscopy, Tissue optics, Cancer, Diagnostics, Biopsy, Kidney, Luminescence, Fluorescence spectroscopy, Tissues, Fiber optics

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Proceedings Article | 4 March 2019 Presentation

Multi-spectral fiber spectroscopy methods as solutions for label-free medical diagnostics (Conference Presentation)

Olga Bibikova, Ervin Nippolainen, Isaac Afara, Julian Haas, Vesa Virtanen, Lasi Rieppo, Sonata Adomaviciute, Harold Brommer, René van Weeren, Anastasia Melenteva, Valeria Belikova, Urszula Zabarylo, Olaf Minet, Juha Töyräs, Valdas Sablinskas, Boris Mizaikoff, Viacheslav Artyushenko

Proceedings Volume 10890, 108901Q (2019) https://doi.org/10.1117/12.2509174

KEYWORDS: Tissues, Medical diagnostics, Spectroscopy, Spectroscopes, Fiber optics, Tissue optics, Kidney, Cartilage, Optical spectroscopy, Molecular spectroscopy

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Proceedings Article | 24 May 2018 Presentation

Single- and multispectral fiber probes as a solution for guided diagnostics and therapy (Conference Presentation)

Olga Bibikova, Urszula Zabarylo, Valeria Belikova, Anastasija Melenteva, Iskander Usenov, Thaddäus Hocotz, Tatiana Sakharova, Alexey Bocharnikov, Georgy Danielyan, Olaf Minet, Hans Eichler, Viacheslav Artyushenko

Proceedings Volume 10685, 106851K (2018) https://doi.org/10.1117/12.2307424

KEYWORDS: Diagnostics, Fluorescence spectroscopy, Luminescence, Fiber optics, Raman spectroscopy, Tissue optics, Spectroscopy, Cancer, Biopsy, Tissues

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Medical fiber optics as a part of laboratory and clinical diagnostic tools, surgical instrumentation and endoscopy should satisfy modern biomedical requirements. The flexibility, small size, bio-compatibility and feasibility to use sterilisable or disposable parts allow to apply fiber optic probes in clinical environment both ex-vivo and in-vivo. To enable spectroscopic differentiation cancer and normal tissue, we developed and applied various single and combined fiber optic probes using key spectroscopy methods such as Raman scattering, Mid IR-absorption, Diffuse NIR-reflection, and fluorescence in order to compare them and select the best combination for malignant detection of tissue in clinical environment. All four spectroscopic methods have been tested on biopsies of health and malignant tissues (colon and kidney) and bioliquids (serum, plasma and urine) of patients before and after surgery. The tiny Raman probe with 1.5 mm diameter has been developed for experimental ex-vivo tests. Further multivariate data analysis of spectroscopic data, both individual techniques and their combinations has provided a reliable cancer recognition for colon and kidney biopsies. The best synergic gain was observed of combining Mid IR-absorption and fluorescence spectroscopy (98% Sensitivity vs 63% or 88% for fluorescence or Mid IR-absorption correspondingly). Based on obtained results, both techniques were implemented within the same fiber probe to provide a simultaneous measurement of exactly the same spot at the sample surface. An innovative combi Fluo-ATR probe was designed, fabricated and tested. Diffuse NIR-reflection and fluorescence spectroscopy as the fastest measurement techniques were used for investigation of surgically removed colorectal tissue samples in a few minutes after resection. Taking into account the necessity of rapid measurement process, we developed multispectral NIR-UV probe that enables efficient excitation and collection of NIR diffuse reflectance and fluorescence spectra of the same point. Needle probe design with diameter 0.7 mm allows to penetrate in some depth of tissue and obtain most reliable spectra avoiding artefacts related to surface drying. Multivariate data analysis proved the increased sensitivity of methods combination in one dataset (94% Sensitivity vs 85% or 85% for fluorescence or NIR reflection correspondingly).

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