The use of modern nonlinear optical crystals (silver thiogalate (AgGaS2), etc.) as active media of optical resonators made it possible to develop and create a highly monochromatic (radiation width less than 1 cm-1) pulsed parametric laser with a wide tuning of the radiation wavelength (from 400 nm to 9100 nm). This paper reports on the operational (during one light pulse with a duration of 20 ns), local (laser spot diameter varies from 50 μm to 10 mm) and high-precision (error no more than 10%) determination of the composition, structure of molecules and their concentration of medicinal substances (drugs). The relevance of this problem is due to two reasons: the identification of counterfeit or poorly produced drugs and the demonstration of the possibility of a parametric laser in the fundamental study of the physicochemical properties of complex organic molecules, the natural vibration frequencies of which fall within the range of tuning the wavelength of pulsed radiation. parametric laser. In this work, a computer simulation of the process of resonant interaction of the radiation frequency of a tunable laser with the natural vibration frequencies of drug molecules was carried out. Using the described OPO, it is possible to register vibrational-rotational spectra, followed by mathematical processing and determination of the main physico-chemical parameters of the studied drug, by the method of differential absorption and scattering.
The paper describes a modernized optical scheme of the LEF3M-1 laser ellipsophotometer with the possibility of automatic determination of the surface microrelief of various materials in situ. Experimental results of registration and processing of ellipsometric patterns reflected from a surface with a microrelief are presented; digital processing was carried out using wavelet analysis methods.
An optical scheme of an optical parametric oscillator (OPO) with a common pumping based on a pulsed YAG:Nd3+ laser (λ=1.064 μm) with a ring resonator based on an active element made of a lithium niobate crystal (LiNbO3), which performs frequency tuning in the near and mid-IR wavelength ranges, is presented. waves (1.41–4.24 μm). A scheme is described and the technical characteristics of a broadband spectrometer developed on the basis of this OPO for medical research based on differential absorption spectroscopy are described. The results of calculation of spectroscopic parameters of the drug ciprofloxacin are presented. It is shown that the developed spectrometer with a tunable radiation frequency makes it possible to confidently detect a large number of organic formations, to identify in them the presence of an increased content of other hazardous impurities that pose a potential threat to health. This method is also applicable to the analysis of human blood components.
A scheme of an infrared (IR) -parametric laser complex for remote detection and identification of the gas phase of trinitrotoluene by the method of differential absorption and scattering in real time is proposed. Calculated studies of the IR absorption spectra of trinitrotoluene in the range of 5.34-8.38 μm have been carried out.
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