Dr. Vanya N. Mantareva Profile

Dr. Vanya N. Mantareva

Associate Professor at IOCCP

SPIE Involvement:

Author

Area of Expertise:

photochemistry , phthalocyanines , singlet oxygen , fluorescence , photodynamic therapy , antimicrobial photoinactivation

Publications (21)

Proceedings Article | 29 April 2022 Paper

The novel photosensitizer galactose: lutetium (Lu)-phthalocyanine for photodynamic therapy in tumor-bearing mice

Alla Bucharskaya, Galina Maslyakova, Nikita Navolokin, Georgy Terentyuk, Vanya Mantareva, Vadim Genin, Elina Genina, Valery Tuchin

Proceedings Volume 12192, 121920Z (2022) https://doi.org/10.1117/12.2627759

KEYWORDS: Photodynamic therapy, Tumors, Lutetium, Tissues, Medical research, Cell death, Skin, Photomicroscopy, Laser sources, Inflammation

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Proceedings Article | 4 May 2021 Paper

The assessment of tumor vascularization degree for predicting the effectiveness of plasmonic photothermal and photodynamic therapy

Alla Bucharskaya, Galina Maslyakova, Marina Chekhonatskaya, Svetlana Pakhomy, Dmitry Mudrak, Nikita Navolokin, Georgy Terentyuk, Ekaterina Borisova, Vanya Mantareva, Ivan Angelov, Boris Khlebtsov, Nikolai Khlebtsov, Vadim Genin, Alexey Bashkatov, Elina Genina, Valery Tuchin

Proceedings Volume 11845, 1184508 (2021) https://doi.org/10.1117/12.2590411

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Proceedings Article | 9 April 2020 Paper

Conjugation of Zn (II) phthalocyanine with polymeric brushes for improved photodiagnostics and photodynamic therapy of gastric tumours

E. Borisova, Ts. Genova, A. Yakimansky, V. Mantareva, I. Angelov, A. Gisbrecht, Al. Khorovodov, I. Agranovich, M. Klimova, O. Semyachkina-Glushkovskaya

Proceedings Volume 11457, 114570R (2020) https://doi.org/10.1117/12.2559938

KEYWORDS: Polymers, Photodynamic therapy, Luminescence, Molecules, In vivo imaging, Cancer, Fluorescence spectroscopy, Tissues

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The target-specific drug release which is depending on the pH of the medium appears precious approach for increasing of drug selectivity and further efficacy in photodynamic diagnosis (PDD) and therapy (PDT) of cancer. A strongly hydrophobic Zn (II) phthalocyanine (ZnPc) along with its liposomal formulates belongs to the clinically approved phthalocyanines for cancer photodiagnosis PDD and PDT. Nevertheless closed to the ideal photo-physicochemical properties the planar molecular structure of ZnPc easily forms aggregates which finally limit the phototoxic effect. Different strategies are on hand, all aiming to minimize the formation of photo-inactive associates. At present time, the polymeric carrier systems are still under development as carrier systems for biomedical applications. The present work evaluated the efficiency of two recently proposed graft - copolymers namely polyimide (PI)-graft-polymethacrylic acid (PAT2 and PAT3) as vehicles of hydrophobic ZnPc. The potential of the proposed polymeric brushes with great number of carboxylic groups, for conformational changes in different pH media, can be used for ZnPc release as studied by fluorescence spectroscopy. Complexes developed were investigated in vivo on rat model system of gastric carcinoma lesions for photodiagnosis and photodynamic treatment of neoplasia and compared with the application of ZnPcs solely. The contrast achieved of the fluorescence detection using polymer brushes - phthalocyanine conjugate is about twice higher that standard applied photosensitizer using same protocol and doses of application. The photodynamic treatment efficacy was also significantly improved allowing to receive full response using doses of 0,5-1 mg/kg of the conjugates. |To obtain same efficiency for the ZnPc PDT in the gastric lesions treated drug doses of 1,5-2 mg/kg had to be applied. Initially detected fluorescence signal and photo-bleaching dynamics were used for the monitoring of the processes of accumulation and photodynamic treatment processes.

Proceedings Article | 2 April 2020 Presentation

Photodynamic treatment of cholangiocarcinoma with phthalocyanine compounds in laboratory animals (Conference Presentation)

Ekaterina Borisova, Alla Bucharskaya, Nikita Navolokin, Vadim Genin, Elina Genina, Alexey Bashkatov, Vanya Mantareva, Ivan Angelov

Proceedings Volume 11363, 1136325 (2020) https://doi.org/10.1117/12.2555952

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The new generations of photoactive compounds, which are derivatives of already well-established groups of photosensitizers, together with the modern light sources in the spectral region of their activation and in the PDT window range, are emerging as a reliable phototherapy approach for tumour treatment with higher efficiency. The substitution of a highly hydrophobic phthalocyanine with galactose units could improve the solubility and to decrease significant aggregation in polar solvents. The control group of rats with transplanted cholangiocarcinoma without any treatment was used for comparison of PDT effectiveness. In the second group the white outbred male rats with cholangiocarcinoma lesions were treated using Zn-phthalocyanine, as a typical representative of phthalocyanine photosensitizers with known photodynamic properties and the third group of animals was treated with galactose – Lu-phthalocyanine, as a novel derivative from the same family with two specific differences – presence of galactose and replacing of Zn(II) with Lu(III) ion. To compare the PDT effectiveness of both compounds the same drug doses were applied - 2 mg/kg, applied by intratumoural injection. Diode laser source at 670 nm, on 50 mW output power with power density applied 200 mW/cm2 was applied for 1000 sec to obtain total irradiation dose of 200 J/cm2 for each lesion. 3 days after treatment, the animals were withdrawn from the experiment. Tissue from the central zone and periphery of the tumor was taken for morphological examination and fixed in 10% formalin. Serial paraffin sections were stained with hematoxilin-eosin and by immunohistochemical staining with antibodies to proliferation marker Ki-67 and apoptosis marker BAX. After photodynamic therapy, pronounced necrobiotic changes in combination with an inflammatory reaction were developed at the central zone of tumors. The dystrophic changes, reduction of proliferation and development of apoptosis in tumor cells were observed on tumor periphery as well.

Proceedings Article | 22 July 2019 Paper

ALA/PpIX photodiagnosis of stress-induced gastrointestinal primary tumors and metastases in experimental animals

Ekaterina Borisova, Tsanislava Genova, Alexander Khorovodov, Ilana Agranovich, Matvey Kanevskiy, Svetlana Konnova, Ivan Angelov, Vanya Mantareva, Nikita Navolokin, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11079, 110790N (2019) https://doi.org/10.1117/12.2526847

KEYWORDS: Stomach, Luminescence, Liver, Tissues, Tumors, Spectroscopy, Cancer, Diagnostics, Fluorescent markers, In vivo imaging

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Proceedings Article | 29 January 2019 Paper

Detection of stress-induced gastrointestinal lesions using Al-phythalocynanines in experimental animals

Ilana Agranovich, Alexander Khorovodov, Matvey Kanevsky, Tsanislava Genova-Hristova, Alexander Gisbrecht, Ivan Angelov, Vanya Mantareva, Nikita Navolokin, Oxana Semyachkina-Glushkovskaya, Ekaterina Borisova

Proceedings Volume 11047, 1104709 (2019) https://doi.org/10.1117/12.2516336

KEYWORDS: Luminescence, Stomach, Tissues, Cancer, Signal detection, Diagnostics, Tumors, Endoscopy, Tissue optics, Fluorescence spectroscopy

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Proceedings Article | 20 February 2018 Paper

Photodynamic diagnostics of stress-induced gastrointestinal neoplasia in laboratory animals using 5-aminolevulinic acid and Al-phthalocyanine

Ekaterina Borisova, Oxana Semyachkina-Glushkovskaya, Nikita Navolokin, Vanya Mantareva, Ivan Angelov, Ilana Agranovich, Alexander Khorovodov, Natalia Shushunova, Anastasiya Bodrova, Ivan Fedosov, Anton Namykin, Arkady Abdurashitov, Latchezar Avramov

Proceedings Volume 10501, 105011E (2018) https://doi.org/10.1117/12.2289159

KEYWORDS: Stomach, Luminescence, Fluorescence spectroscopy, Cancer, Endoscopy, Colon, Tissues, Diagnostics, Tissue optics, Brain

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Proceedings Article | 8 January 2015 Paper

Antimicrobial photodisinfection with Zn(II) phthalocyanine adsorbed on TiO2 upon UVA and red irradiation

Vanya Mantareva, Ivelina Eneva, Vesselin Kussovski, Ekaterina Borisova, Ivan Angelov

Proceedings Volume 9447, 94470W (2015) https://doi.org/10.1117/12.2084307

KEYWORDS: Pathogens, Luminescence, Solids, Absorption, Nanoparticles, Light emitting diodes, Confocal microscopy, Light sources, Composites, Titanium dioxide

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Proceedings Article | 15 March 2013 Paper

Specific light exposure of galactosylated Zn(II) phthalocyanines for selective PDT effects on breast cancer cells

V. Mantareva, A. Kril, I. Angelov, L. Avramov

Proceedings Volume 8770, 877015 (2013) https://doi.org/10.1117/12.2012013

KEYWORDS: Photodynamic therapy, Tumors, Luminescence, Ultraviolet radiation, Picosecond phenomena, Breast cancer, Phototherapy, Light emitting diodes, Oxygen, Molecules

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Proceedings Article | 8 May 2012 Paper

Al(III), Pd(II), and Zn(II) phthalocyanines for inactivation of dental pathogen Aggregatibacter actinomycetemcomitans as planktonic and biofilm-cultures

V. Kussovski, V. Mantareva, I. Angelov, L. Avramov, E. Popova, S. Dimitrov

Proceedings Volume 8427, 84273X (2012) https://doi.org/10.1117/12.923050

KEYWORDS: Bacteria, Pathogens, Photodynamic therapy, Luminescence, Microorganisms, Absorption, Oxygen, Tissues, Metals, Toxicity

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Proceedings Article | 8 May 2012 Paper

Effects of the position of galactose units to Zn(II) phthalocyanine on the uptake and photodynamic activity towards breast cancer cells

V. Mantareva, A. Kril, I. Angelov, R. Dimitrov, E. Borisova, L. Avramov

Proceedings Volume 8427, 842743 (2012) https://doi.org/10.1117/12.923794

KEYWORDS: Luminescence, Oxygen, Tumors, Quantum efficiency, Breast cancer, Absorption, Photodynamic therapy, In vitro testing, Picosecond phenomena, Absorbance

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Proceedings Article | 8 May 2012 Paper

Photodynamic therapy with water-soluble phtalocyanines against bacterial biofilms in teeth root canals

Raina Gergova, Tzvetelina Georgieva, Ivan Angelov, Vanya Mantareva, Serjoga Valkanov, Ivan Mitov, Slavcho Dimitrov

Proceedings Volume 8427, 842744 (2012) https://doi.org/10.1117/12.923859

KEYWORDS: Photodynamic therapy, Teeth, Bacteria, Pathogens, Microorganisms, Medicine, Resistance, Silicon, Picosecond phenomena, Scanning electron microscopy

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Proceedings Article | 8 February 2011 Paper

Susceptibility of representative dental pathogens to inactivation by the PDT with water-soluble photosensitizers

Ivan Angelov, Vanya Mantareva, Veselin Kussovski, Diter Worle, Hristo Kisov, Marieta Belcheva, Tzvetelina Georgieva, Slavcho Dimitrov

Proceedings Volume 7994, 79941A (2011) https://doi.org/10.1117/12.881011

KEYWORDS: Photodynamic therapy, Pathogens, Bacteria, Microorganisms, Oxygen, Fungi, Resistance, Dentistry, Organisms, Mouth

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Proceedings Article | 18 January 2011 Paper

New method of control of tooth whitening

I. Angelov, V. Mantareva, A. Gisbrecht, S. Valkanov, Tz. Uzunov

Proceedings Volume 7747, 77470Y (2011) https://doi.org/10.1117/12.882573

KEYWORDS: Teeth, Luminescence, Signal processing, Scattering, Chromophores, Light scattering, Scanning electron microscopy, Hydrogen, Macromolecules, Light emitting diodes

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Proceedings Article | 18 January 2011 Paper

Water-soluble phthalocyanine complexes of Ga(III) and In(III) in the photodynamic inactivation of pathogenic fungus

V. Mantareva, I. Angelov, D. Wöhrle, V. Dogandjiska, R. Dimitrov, V. Kussovski

Proceedings Volume 7747, 774712 (2011) https://doi.org/10.1117/12.882065

KEYWORDS: Pathogens, Photodynamic therapy, Oxygen, Luminescence, Microorganisms, Absorption, Metals, Quantum efficiency, Chemical species, Molecules

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Proceedings Article | 19 December 2008 Paper

Improved antimicrobial therapy with cationic tetra- and octa-substituted phthalocyanines

I. Angelov, V. Mantareva, V. Kussovski, D. Woehrle, E. Borisova, L. Avramov

Proceedings Volume 7027, 702717 (2008) https://doi.org/10.1117/12.822519

KEYWORDS: Bacteria, Photodynamic therapy, Molecules, Pathogens, Picosecond phenomena, Resistance, Microorganisms, Luminescence, Oxygen, Viruses

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Proceedings Article | 5 March 2007 Paper

Phthalocyanine-assisted photodynamic inactivation of pathogenic microorganisms

Vanya Mantareva, Ivan Angelov, Ekaterina Borissova, Latchezar Avramov, Vesselin Kussovski

Proceedings Volume 6604, 66042A (2007) https://doi.org/10.1117/12.727717

KEYWORDS: Bacteria, Microorganisms, Luminescence, Pathogens, Yeast, Fungi, Absorption, Molecules, Aluminum, Quantum efficiency

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Proceedings Article | 22 April 2005 Paper

Tumor detection by exogenous fluorescent dyes using new generation photo-multiplier tubes

Ekaterina Borisova, I. Angelov, Vanya Mantareva, D. Petrova, Peter Townsend, L. Valberg, Lachezar Avramov

Proceedings Volume 5830, (2005) https://doi.org/10.1117/12.618833

KEYWORDS: Luminescence, Tissues, Signal detection, Sensors, Melanoma, Ocean optics, Absorption, Tumors, Spectroscopy, Tissue optics

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The easy and non-destructive fluorescence method for quantification of early changes in biological tissues improves the possibilities of the clinical research and diagnostics. Developments in this area are moving very rapidly in part because of advances in the technology and in part because of the numerous successful examples which are appearing. New family of photomultiplier tubes with a high detection sensitivity for near-infra red light (700-900 nm) were developed as a result of project IMPECABLE, which are valuable tools for early diagnosis of cutaneous pigmented melanoma using long-wave fluorescence dyes. Several phthalocyanines that are promising fluorophores for photodiagnosis of cutaneous malignant melanoma have been studied in different solvents for concentrations from 10^-5 to 10^-15 mol. Argon pumped dye laser as an excitation source was used. Three different wavelengths (613, 633 and 660 nm) in the red region, corresponding to first absorption peak, minimum of the absorption and near to the Q-band maximum of Pcs were applied. Fluorescence signals in the region of 700 to 800 nm were detected using spectrometric systems (Perkin-Elmer, UK-with conventional PMT as a detector, and PC2000, Ocean Optics, USA-with CCD-array as a detector) and a newly developed red-sensitive PMT. Detectable signal from other spectrometric systems was obtain up to 10^-8 mol concentrations, which could be used for significant reduction of concentrations applied for in vivo applications. Fluorescence is a highly sensitive method of distinguishing between healthy and unhealthy tissue. The results demonstrate that extremely low concentrations of photosensitizers could be used to determine initial stages of melanoma. This application of PMT detectors will reduce extremely the negative side effects of higher concentrations of these drugs applied in the skin tissue. One can achieve high accuracy in the determination of pigmented malignant melanoma lesions with wide clinical applications.

SPIE Journal Paper | 1 July 1999 Open Access

Naphthalocyanine-complexes as potential photosensitizers for PDT of tumors

Maria Shopova, Dieter Woehrle, Vanya Mantareva, Silke Mueller

JBO, Vol. 4, Issue 03, (July 1999) https://doi.org/10.1117/12.10.1117/1.429930

KEYWORDS: Tumors, Photodynamic therapy, Melanoma, Magnesium, Tissues, Electroluminescence, Lung, Tissue optics, Tumor growth modeling, Luminescence

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Proceedings Article | 4 December 1996 Paper

Experimental PDT: studies on new Si-phthalocyanines and Si-naphthalocyanines in Cremophor emulsions

Maria Shopova, Vanya Mantareva, Dieter Woehrle, Silke Mueller

Proceedings Volume 2924, (1996) https://doi.org/10.1117/12.260764

KEYWORDS: Tumors, Silicon, Photodynamic therapy, In vivo imaging, Absorption, Electroluminescence, Lung, Toxicity, Tumor growth modeling, Oxygen

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In the present work the following silicon (IV) - phthalocyanines and -naphthalocyanines bearing methoxyethylene glycol or methoxypolyethylene glycol covalently bound at the silicon are investigated: SiPc[OCH₂CH₂OCH₃]₂ (SiPc1), SiNc[OCH₂CH₂OCH₃]₂ (SiNc), SiPc[(OCH₂CH₂)_nOCH₃] with n approximately 115 (SiPc2). The phototherapeutic effect was shown at Lewis lung carcinoma implanted in mice. SiPc2 is monomeric soluble in water whereas the other two compounds aggregated in this solvent. Therefore these compounds were dissolved monomer in in aqueous Cremophor solution before in vivo administration. Laser irradiation was applied 7 days after implantation and 24 h after drug administration at the following wavelength (eta) _ext: 672 nm for SiPc1 and SiPc2, 782 nm for SiNc. In all cases a fluence rate of 370 mW/cm² at fluence of 360 J/cm² was used. The assessment criteria for the tumor response were the changes in the mean tumor diameter with time, regrowth delay and average survival time (AST). According to the first parameter the most promising result was obtained after treatment with SiPc1. For example the mean tumor diameter increases as follows: SiPc1 less than SiPc2 less than SiNc very much less than control group without photosensitizer. The regrowth delay showed the same trend. however, for AST another dependence was observed. AST was the longest for SiPc2 (26 days) and shortest for SiNc (22 days). Compared to the control group (without sensitizer and irradiation) the AST was 9 days longer after SiPc2 treatment. Comparing SiPc1 and SiPc2 the chain length of the substituents does not influence the phototherapeutic properties. The detected therapeutic results probably are connected with the long wavelength absorption of the photosensitizers. The relatively lower affectivity of SiNc may be due to a lower degree of tumor accumulation as it was observed in our preliminary pharmacokinetic studies. It is also possible that the shorter AST after treatment with SiNc is connected with a greater dark toxicity.

Proceedings Article | 12 January 1995 Paper

Influence of photodynamic therapy on the delay of metastasis development in Lewis lung carcinoma

Vanya Mantareva, Kroum Kassabov, Maria Shopova, Silke Muller, Dieter Woehrle

Proceedings Volume 2325, (1995) https://doi.org/10.1117/12.199167

KEYWORDS: Photodynamic therapy, Tumors, Lung, Absorption, Zinc, Tumor growth modeling, Cancer, Tissues, Chemical analysis, Dye lasers

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