Gold metarsurfaces are widely used in sensing due to their ability to enhance localized light fields. To reduce the manufacturing cost of gold metasurfaces, we proposed a reusable metasurface biosensor based on parylene C with microfluidic technology. The electric field distribution of the gold metasurface was simulated using the finite-difference time-domain (FDTD) method. The polydimethylsiloxane (PDMS) microfluidic channels were bounded on the surface of the biosensor to provide specific reaction area to detect different concentrations of NaCl solution. For the purpose of reusability, the growth and removal of parylene C on the metasurface were realized. Besides, the parylene C film acted as the connection layer to enable the one-step physical modification of antigen and antibody, which made highly efficient biosensing possible. The feasibility of this approach is experimentally validated and has potential to be widely used in other metasurface biosensors.
Optical biosensors provide important opportunities and have broad application prospects in biomedicine, disease diagnosis, pharmaceutical, and other fields. In this paper, a reusable VCSEL (vertical cavity surface emitting laser) biosensor chip integrated with a multilayer nano grating structure is introduced. The selected laser wavelength is 850 nm, and the overall device adopts semiconductor laser packaging technology to achieve high integration of light source and multilayer nano grating. A small plasmonic biosensor platform based on hyperbolic metamaterial (HMMs) Au/Si3N4 is studied using the grating coupling principle. The transmission peak is adjusted to the wavelength of 850 nm by changing the nano grating parameters so as to improve the sensitivity of the sensor chip. However, the high cost of the sensor chip which is based on noble metal nanostructure and precision technology hinders its further application. In this paper, we propose to grow and remove parylene film on the sensor chip to realize the reuse of biosensors.
Biosensors have broad application prospects in biomedicine, pharmacy, chemical industry and environmental monitoring. Therefore, the research and development of biosensors has become a new hotspot in the development of science and technology in the world. A vertical cavity surface emitting laser (VCSEL) biosensor chip integrated with gold nanostructures is introduced in this paper. The chip mainly uses the packaging technology of semiconductor laser to realize the high integration of light source, hexagonal gold nanoparticle array, and detection system. We use anodic aluminum oxide film (AAO) as a mask to prepare hexagonal gold nanoparticle array, combined with a microfluidic chip to realize the sensing application that can be sensitive to the change of environmental solution. We modify the gold nanoparticles on the chip surface with specific antibodies, and then inject different concentrations of protein solution for detection. The output light power changes with the change of environmental solution, so as to detect the concentration and type of biological solution. The sensor has the advantages of low cost, high sensitivity, and high integration.
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